Source: https://flybase.org/reports/FBgn0262587
Retrieved 2026-09-08
FlyBase Gene Report: Dmel\CG43124 Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Sign In Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Gene: Dmel\CG43124 J2G Search Go Open Close General Information Symbol Dmel\ CG43124 Species D. melanogaster Name Annotation Symbol CG43124 Feature Type protein_coding_gene FlyBase ID FBgn0262587 Gene Model Status Current Stock Availability None publicly available Gene Summary (Alliance, FBgn0262587 ) (FlyBase Automatically Generated Summary) Contribute a Gene Snapshot for this gene. All Summaries Alliance Auto summary Gene Group Interactive Fly Key Links Genomic Location Cytogenetic map 98C3-98C3 Sequence location 3R:28,263,871..28,264,773 [-] Recombination map (full details) 3-95 RefSeq locus NT_033777 REGION: 28263871..28264773 Sequence Gene region Extended Gene region CDS Introns Exons Transcripts Translations 5' UTR 3' UTR Get Sequence Get Decorated FASTA Genomic Maps JBrowse Other Genome Views The following external sites may use different assemblies or annotations than FlyBase. NCBI UCSC Ensembl PopFly Function Gene Ontology (GO) Annotations (4 terms) Molecular Function (3 terms) Terms Based on Experimental Evidence (0 terms) Terms Based on Predictions or Assertions (2 terms) CV Term Evidence References NOT enables peptidase activity inferred from key residues with MEROPS:S01.UNA ( GO curators,  2012- ) NOT enables serine-type endopeptidase activity inferred from key residues ( Cao and Jiang,  2018 ) Biological Process (2 terms) Terms Based on Experimental Evidence (0 terms) Terms Based on Predictions or Assertions (2 terms) CV Term Evidence References involved_in innate immune response inferred from biological aspect of ancestor with PANTHER:PTN000667087 ( GO Reference Genome Project,  2011- ) involved_in proteolysis inferred from electronic annotation with InterPro:IPR001254 ( InterPro Project Members,  2004- ) Cellular Component (1 term) Terms Based on Experimental Evidence (0 terms) Terms Based on Predictions or Assertions (0 terms) Gene Group (FlyBase) S1A NON-PEPTIDASE HOMOLOGS Protein Family ( UniProt ) - Protein Signatures ( InterPro ) Peptidase S1, PA clan Serine/Threonine Proteases with Immune and Developmental Roles Serine proteases, trypsin domain Summaries Automated Description (Alliance of Genome Resources) (Alliance, FBgn0262587 ) Automatically Generated Summary (FlyBase) Gene Group (FlyBase) S1A NON-PEPTIDASE HOMOLOGS - Serine protease homologs of the S1A family are similar in amino acid sequence to S1A serine proteases but are enzymatically inactive due to the lack of catalytic residue(s). Their functions are generally poorly understood, though at least some of them have known regulatory functions. (Adapted from FBrf0155784 & FBrf0240739 .) Gene Model and Products Number of Transcripts 1 Number of Unique Polypeptides 1 Please see the JBrowse view of Dmel\ CG43124 for information on other features To submit a correction to a gene model please use the Contact FlyBase form Protein Domains (via Pfam) Isoform displayed: Pfam protein domains InterPro name classification start end Protein Domains (via SMART) Isoform displayed: SMART protein domains InterPro name classification start end Structure Protein 3D structure   (Predicted by AlphaFold )  
                    ( AlphaFold entry A0A0B4K7P3 ) If you don't see a structure in the viewer, refresh your browser. Model Confidence: Very high (pLDDT > 90) Confident (90 > pLDDT > 70) Low (70 > pLDDT > 50) Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
                          Some regions with low pLDDT may be unstructured in isolation. Experimentally Determined Structures Crossreferences Comments on Gene Model Gene model reviewed during 5.53 Transcript Data Annotated Transcripts Name FlyBase ID RefSeq ID Length (nt) Assoc. CDS (aa) CG43124-RA FBtr0305116 NM_001260416 784 245 Additional Transcript Data and Comments Reported size (kB) Comments External Data Crossreferences Polypeptide Data Annotated Polypeptides Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI UniProt RefSeq ID GenBank CG43124-PA FBpp0293647 28.4 245 8.18 A0A0B4K7P3 NP_001247345 AFH06662 Polypeptides with Identical Sequences There is only one protein coding transcript and one polypeptide associated with this gene Additional Polypeptide Data and Comments Reported size (kDa) Comments External Data Crossreferences InterPro -
                  A database of protein families, domains and functional sites Serine proteases, trypsin domain Peptidase S1, PA clan Serine/Threonine Proteases with Immune and Developmental Roles Linkouts Sequences Consistent with the Gene Model Nucleotide / Polypeptide Records AE014297 / AFH06662 BT128716 CO182670 CO185201 UniProt A0A0B4K7P3 Mapped Features Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping
                        Dmel\CG43124
                        using the Feature Mapper tool. Feature Mapper External Data Crossreferences Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. CG43124_1 Linkouts Expression Data Testis-specificity index The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al. , 2018 to indicate the degree of testis enrichment compared to other tissues.
                Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias). -0.33 Transcript Expression Additional Descriptive Data Marker for Subcellular Localization CV Term Polypeptide Expression Additional Descriptive Data Marker for Subcellular Localization CV Term Evidence References Expression Deduced from Reporters High-Throughput Expression Data Associated Tools JBrowse - Visual display of RNA-Seq signals View Dmel\ CG43124 in JBrowse RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region View exonic expression by developmental stage for Dmel\ CG43124 View exonic expression by tissue for Dmel\ CG43124 Bulk Downloads RNA-Seq RPKM values for all genes Reference See Gelbart and Emmert, 2013 for analysis details and data files for all genes. Developmental Proteome: Life Cycle Developmental Proteome: Embryogenesis CG43124 External Data and Images Linkouts DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 12798282/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0262587 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0262587 Images FlyBase Wiki Image Based Resources Alleles, Insertions, Transgenic Constructs, and Aberrations Classical and Insertion Alleles
            ( 0 ) For All Classical and Insertion Alleles Show Pre-selected data Choose specific data Other relevant insertions Transgenic Constructs
            ( 1 ) For All Alleles Carried on Transgenic Constructs Show Pre-selected data Choose specific data Transgenic constructs containing/affecting coding region of CG43124 Transgenic constructs containing regulatory region of CG43124 Aberrations (Deficiencies and Duplications)
              ( 0 ) Inferred from experimentation
                  ( 0 ) Inferred from location
                  ( 4 ) Export to HitList Df(3R)BSC460 Df(3R)BSC567 Df(3R)BSC881 Dp(3;2)GV-CH321-70P13 Variants Variant Molecular Consequences Alleles Representing Disease-Implicated Variants Phenotypes For more details about a specific phenotype click on the relevant allele symbol. Phenotype manifest in Allele Orthologs Downloads Download All DIOPT Orthologs Human Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Homo sapiens (Human) (36) Hsap\ACR 1 of 14 Yes No Hsap\C1S 1 of 14 Yes No 1 Hsap\CELA1 1 of 14 Yes No Hsap\CTRB1 1 of 14 Yes No Hsap\CTRB2 1 of 14 Yes No Hsap\CTRL 1 of 14 Yes No Hsap\F7 1 of 14 Yes No Hsap\F10 1 of 14 Yes No 1 Hsap\F11 1 of 14 Yes No 1 Hsap\GZMH 1 of 14 Yes No 1 Hsap\GZMM 1 of 14 Yes Yes Hsap\KLK6 1 of 14 Yes No 1 Hsap\KLK7 1 of 14 Yes No Hsap\KLK8 1 of 14 Yes No Hsap\KLK9 1 of 14 Yes No Hsap\KLK13 1 of 14 Yes No Hsap\KLK14 1 of 14 Yes No Hsap\OVCH1 1 of 14 Yes No Hsap\PROC 1 of 14 Yes No 1 Hsap\PRSS8 1 of 14 Yes No 1 Hsap\PRSS12 1 of 14 Yes No Hsap\PRSS21 1 of 14 Yes No Hsap\PRSS41 1 of 14 Yes No Hsap\PRSS42P 1 of 14 Yes No Hsap\PRSS48 1 of 14 Yes No Hsap\PRSS50 1 of 14 Yes No Hsap\PRSS53 1 of 14 Yes No Hsap\PRSS56 1 of 14 Yes No Hsap\TMPRSS2 1 of 14 Yes No Hsap\TMPRSS3 1 of 14 Yes No Hsap\TMPRSS4 1 of 14 Yes No Hsap\TMPRSS5 1 of 14 Yes No Hsap\TMPRSS6 1 of 14 Yes No Hsap\TMPRSS11D 1 of 14 Yes No Hsap\TMPRSS12 1 of 14 Yes No Hsap\TMPRSS13 1 of 14 Yes No Model Organism Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Rattus norvegicus (Norway rat) (16) Rnor\Ctrl 1 of 14 Yes No Rnor\F10 1 of 14 Yes No Rnor\F11 1 of 14 Yes No Rnor\Gzmk 1 of 14 Yes No Rnor\Hpn 1 of 14 Yes No Rnor\Klk8 1 of 14 Yes No Rnor\Klk13 1 of 14 Yes No Rnor\Proc 1 of 14 Yes No Rnor\Prss8 1 of 14 Yes No Rnor\Prss32 1 of 14 Yes No Rnor\Prss45 1 of 14 Yes No Rnor\Prss48 1 of 14 Yes No Rnor\Tmprss2 1 of 14 Yes No Rnor\Tmprss3 1 of 14 Yes No Rnor\Tmprss6 1 of 14 Yes No Rnor\Tmprss13 1 of 14 Yes No Mus musculus (laboratory mouse) (26) Mmus\Acr 1 of 14 Yes No Mmus\C1s1 1 of 14 Yes Yes Mmus\Ctrl 1 of 14 Yes No Mmus\F10 1 of 14 Yes No Mmus\F11 1 of 14 Yes No Mmus\Hpn 1 of 14 Yes No Mmus\Klk4 1 of 14 Yes No Mmus\Klk5 1 of 14 Yes No Mmus\Klk6 1 of 14 Yes No Mmus\Klk8 1 of 14 Yes No Mmus\Klk9 1 of 14 Yes No Mmus\Klk12 1 of 14 Yes No Mmus\Klk13 1 of 14 Yes No Mmus\Klkb1 1 of 14 Yes No Mmus\Masp2 1 of 14 Yes No Mmus\Proc 1 of 14 Yes No Mmus\Prss8 1 of 14 Yes No Mmus\Prss22 1 of 14 Yes No Mmus\Prss41 1 of 14 Yes No Mmus\Prss43 1 of 14 Yes No Mmus\Prss45 1 of 14 Yes No Mmus\Prss56 1 of 14 Yes No Mmus\Tmprss2 1 of 14 Yes No Mmus\Tmprss3 1 of 14 Yes No Mmus\Tmprss6 1 of 14 Yes No Mmus\Tmprss13 1 of 14 Yes No Xenopus tropicalis (Western clawed frog) (19) Xtro\cfb 1 of 13 Yes Yes Xtro\f7 1 of 13 Yes No Xtro\hoxc4 1 of 13 Yes No Xtro\LOC548809 1 of 13 Yes No Xtro\LOC101732176 1 of 13 Yes No Xtro\LOC108648818 1 of 13 Yes No Xtro\LOC116407686 1 of 13 Yes No Xtro\LOC116408674 1 of 13 Yes Yes Xtro\LOC116411715 1 of 13 Yes No Xtro\proz 1 of 13 Yes No Xtro\prss12 1 of 13 Yes No Xtro\prss56 1 of 13 Yes No Xtro\tmprss2.12 1 of 13 Yes No Xtro\tmprss2.15 1 of 13 Yes No Xtro\tmprss9 1 of 13 Yes No Xtro\tmprss13 1 of 13 Yes No Xtro\tpsg1 1 of 13 Yes No Xtro\XB5723326 1 of 13 Yes No Xtro\XB5892359 1 of 13 Yes No Danio rerio (Zebrafish) (25) Drer\ctrb.3 1 of 14 Yes No Drer\ctrl 1 of 14 Yes No Drer\ela2 1 of 14 Yes No Drer\f2 1 of 14 Yes No Drer\f9b 1 of 14 Yes No Drer\f10 1 of 14 Yes No Drer\LOC103908930 1 of 14 Yes No Drer\LOC110439065 1 of 14 Yes Yes Drer\LOC110439069 1 of 14 Yes Yes Drer\proca 1 of 14 Yes No Drer\prss60.2 1 of 14 Yes No Drer\si:dkey-9p24.5 1 of 14 Yes Yes Drer\si:dkey-32n7.7 1 of 14 Yes No Drer\si:dkey-78l4.6 1 of 14 Yes No Drer\si:dkeyp-93a5.2 1 of 14 Yes No Drer\si:dkeyp-93a5.3 1 of 14 Yes No Drer\tmprss2 1 of 14 Yes No Drer\tmprss13a 1 of 14 Yes No Drer\zgc:100868 1 of 14 Yes No Drer\zgc:112038 1 of 14 Yes No Drer\zgc:123217 1 of 14 Yes No Drer\zgc:123295 1 of 14 Yes No Drer\zgc:153968 1 of 14 Yes No Drer\zgc:165423 1 of 14 Yes No Drer\zgc:171509 1 of 14 Yes No Caenorhabditis elegans (Nematode, roundworm) (7) Cele\T22A3.6 1 of 14 Yes Yes Cele\try-1 1 of 14 Yes No Cele\try-3 1 of 14 Yes No Cele\try-4 1 of 14 Yes No Cele\try-5 1 of 14 Yes No Cele\try-9 1 of 14 Yes No Cele\try-10 1 of 14 Yes No Anopheles gambiae (African malaria mosquito) (101) Agam\AgaP_AGAP003686 2 of 12 Yes No Agam\CLIPB11 2 of 12 Yes No Agam\CLIPB13 2 of 12 Yes No Agam\CLIPB18 2 of 12 Yes No Agam\AgaP_AGAP001365 1 of 12 No No Agam\AgaP_AGAP001964 1 of 12 No No Agam\AgaP_AGAP003248 1 of 12 No No Agam\AgaP_AGAP003627 1 of 12 No No Agam\AgaP_AGAP003960 1 of 12 No No Agam\AgaP_AGAP004149 1 of 12 No No Agam\AgaP_AGAP004566 1 of 12 No No Agam\AgaP_AGAP004568 1 of 12 No No Agam\AgaP_AGAP004569 1 of 12 No No Agam\AgaP_AGAP004570 1 of 12 No No Agam\AgaP_AGAP004571 1 of 12 No No Agam\AgaP_AGAP004858 1 of 12 No No Agam\AgaP_AGAP004900 1 of 12 No No Agam\AgaP_AGAP005072 1 of 12 No No Agam\AgaP_AGAP005303 1 of 12 No No Agam\AgaP_AGAP005702 1 of 12 No No Agam\AgaP_AGAP005704 1 of 12 No No Agam\AgaP_AGAP006120 1 of 12 No No Agam\AgaP_AGAP006539 1 of 12 No No Agam\AgaP_AGAP006672 1 of 12 No No Agam\AgaP_AGAP007043 1 of 12 No No Agam\AgaP_AGAP007795 1 of 12 No No Agam\AgaP_AGAP008403 1 of 12 No No Agam\AgaP_AGAP008558 1 of 12 No No Agam\AgaP_AGAP008994 1 of 12 No No Agam\AgaP_AGAP008995 1 of 12 No No Agam\AgaP_AGAP008996 1 of 12 No No Agam\AgaP_AGAP008997 1 of 12 No No Agam\AgaP_AGAP009211 1 of 12 No No Agam\AgaP_AGAP009216 1 of 12 No No Agam\AgaP_AGAP009218 1 of 12 No No Agam\AgaP_AGAP009220 1 of 12 No No Agam\AgaP_AGAP009249 1 of 12 No No Agam\AgaP_AGAP009251 1 of 12 No No Agam\AgaP_AGAP009828 1 of 12 No No Agam\AgaP_AGAP009849 1 of 12 No No Agam\AgaP_AGAP010545 1 of 12 No No Agam\AgaP_AGAP010546 1 of 12 No No Agam\AgaP_AGAP010635 1 of 12 No No Agam\AgaP_AGAP010662 1 of 12 No No Agam\AgaP_AGAP010730 1 of 12 No No Agam\AgaP_AGAP011040 1 of 12 No No Agam\AgaP_AGAP011325 1 of 12 No No Agam\AgaP_AGAP011427 1 of 12 No No Agam\AgaP_AGAP011669 1 of 12 No No Agam\AgaP_AGAP011719 1 of 12 No No Agam\AgaP_AGAP011913 1 of 12 No No Agam\AgaP_AGAP012020 1 of 12 No No Agam\AgaP_AGAP012022 1 of 12 No No Agam\AgaP_AGAP012270 1 of 12 No No Agam\AgaP_AGAP012277 1 of 12 No No Agam\AgaP_AGAP012328 1 of 12 No No Agam\AgaP_AGAP012502 1 of 12 No No Agam\AgaP_AGAP012504 1 of 12 No No Agam\AgaP_AGAP012505 1 of 12 No Yes Agam\AgaP_AGAP012614 1 of 12 No No Agam\AgaP_AGAP012817 1 of 12 No No Agam\AgaP_AGAP012946 1 of 12 No No Agam\AgaP_AGAP013089 1 of 12 No No Agam\AgaP_AGAP013117 1 of 12 No Yes Agam\AgaP_AGAP013221 1 of 12 No No Agam\AgaP_AGAP013452 1 of 12 No No Agam\AgaP_AGAP013487 1 of 12 No No Agam\CLIPA2 1 of 12 No No Agam\CLIPA4 1 of 12 No No Agam\CLIPA5 1 of 12 No No Agam\CLIPA8 1 of 12 No No Agam\CLIPA9 1 of 12 No No Agam\CLIPB1 1 of 12 No No Agam\CLIPB2 1 of 12 No No Agam\CLIPB3 1 of 12 No No Agam\CLIPB4 1 of 12 No No Agam\CLIPB5 1 of 12 No No Agam\CLIPB6 1 of 12 No No Agam\CLIPB8 1 of 12 No No Agam\CLIPB9 1 of 12 No No Agam\CLIPB10 1 of 12 No No Agam\CLIPB12 1 of 12 No No Agam\CLIPB15 1 of 12 No No Agam\CLIPB17 1 of 12 No No Agam\CLIPB19 1 of 12 No No Agam\CLIPB20 1 of 12 No Yes Agam\CLIPB36 1 of 12 No No Agam\CLIPC1 1 of 12 No No Agam\CLIPC2 1 of 12 No No Agam\CLIPC3 1 of 12 No No Agam\CLIPC4 1 of 12 No No Agam\CLIPD1 1 of 12 No No Agam\CLIPD2 1 of 12 No No Agam\CLIPD3 1 of 12 No No Agam\CLIPD4 1 of 12 No No Agam\CLIPD6 1 of 12 No No Agam\CLIPD7 1 of 12 No No Agam\CLIPD8 1 of 12 No No Agam\CLIPE7 1 of 12 No No Agam\TRY5_ANOGA 1 of 12 No No Agam\TRY6_ANOGA 1 of 12 No No Arabidopsis thaliana (thale-cress) (0) Saccharomyces cerevisiae (Brewer's yeast) (0) Schizosaccharomyces pombe (Fission yeast) (0) Escherichia coli (enterobacterium) (0) Other Organism Orthologs (via OrthoDB) Data provided directly from OrthoDB:CG43124 .
              Refer to their site for version information. Paralogs Downloads Download All DIOPT Paralogs Paralogs (via DIOPT v9.1) Gene Symbol Score Source Compara Domainoid eggNOG Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Drosophila melanogaster (Fruit fly) (153) CG4650 3 of 13 CG10764 3 of 13 CG14088 3 of 13 CG18420 3 of 13 CG18636 3 of 13 CG30087 3 of 13 CG30091 3 of 13 CG30098 3 of 13 CG30187 3 of 13 CG30286 3 of 13 CG33461 3 of 13 CG33462 3 of 13 CG33465 3 of 13 CG42694 3 of 13 CG43110 3 of 13 CG43125 3 of 13 CG43335 3 of 13 CG43336 3 of 13 CG43742 3 of 13 Erasp 3 of 13 CG5255 2 of 13 CG8870 2 of 13 CG9737 2 of 13 CG10232 2 of 13 CG11529 2 of 13 CG11843 2 of 13 CG14227 2 of 13 CG16710 2 of 13 CG30082 2 of 13 CG30083 2 of 13 CG30088 2 of 13 CG30283 2 of 13 CG30287 2 of 13 CG30288 2 of 13 CG30289 2 of 13 CG30414 2 of 13 CG31205 2 of 13 CG33225 2 of 13 CG33226 2 of 13 CG33458 2 of 13 CG33459 2 of 13 CG33460 2 of 13 CG34436 2 of 13 CG34437 2 of 13 Hayan 2 of 13 MP1 2 of 13 psh 2 of 13 scaf 2 of 13 snk 2 of 13 SPE 2 of 13 CG1299 1 of 13 CG1773 1 of 13 CG3088 1 of 13 CG3355 1 of 13 CG3505 1 of 13 CG3700 1 of 13 CG4053 1 of 13 CG4613 1 of 13 CG4815 1 of 13 CG4914 1 of 13 CG5246 1 of 13 CG5909 1 of 13 CG6592 1 of 13 CG6865 1 of 13 CG7432 1 of 13 CG7542 1 of 13 CG8172 1 of 13 CG8329 1 of 13 CG8952 1 of 13 CG9294 1 of 13 CG9372 1 of 13 CG9377 1 of 13 CG9649 1 of 13 CG9733 1 of 13 CG9897 1 of 13 CG10469 1 of 13 CG10472 1 of 13 CG10477 1 of 13 CG11192 1 of 13 CG11313 1 of 13 CG11664 1 of 13 CG11670 1 of 13 CG11836 1 of 13 CG11841 1 of 13 CG11842 1 of 13 CG11911 1 of 13 CG12133 1 of 13 CG13318 1 of 13 CG13430 1 of 13 CG13527 1 of 13 CG13744 1 of 13 CG14642 1 of 13 CG15046 1 of 13 CG15873 1 of 13 CG17234 1 of 13 CG17239 1 of 13 CG17475 1 of 13 CG17477 1 of 13 CG17572 1 of 13 CG18179 1 of 13 CG18180 1 of 13 CG18223 1 of 13 CG18477 1 of 13 CG18735 1 of 13 CG18754 1 of 13 CG30002 1 of 13 CG30323 1 of 13 CG31199 1 of 13 CG31200 1 of 13 CG31219 1 of 13 CG31220 1 of 13 CG31265 1 of 13 CG31269 1 of 13 CG31326 1 of 13 CG31780 1 of 13 CG32260 1 of 13 CG32376 1 of 13 CG32834 1 of 13 CG34171 1 of 13 CG34409 1 of 13 ea 1 of 13 flz 1 of 13 grass 1 of 13 Jon25Biii 1 of 13 Jon25Bii 1 of 13 Jon25Bi 1 of 13 Jon44E 1 of 13 Jon65Aiii 1 of 13 Jon65Aii 1 of 13 Jon65Ai 1 of 13 Jon65Aiv 1 of 13 Jon66Cii 1 of 13 Jon66Ci 1 of 13 Jon74E 1 of 13 Jon99Cii 1 of 13 Jon99Ci 1 of 13 Jon99Fii 1 of 13 Jon99Fi 1 of 13 l(2)k05911 1 of 13 modSP 1 of 13 Np 1 of 13 Sb 1 of 13 Send1 1 of 13 Send2 1 of 13 Ser12 1 of 13 Sp7 1 of 13 Sph35 1 of 13 Sph242 1 of 13 sphinx1 1 of 13 sphinx2 1 of 13 spirit 1 of 13 tpr 1 of 13 yip7 1 of 13 Human Disease Associations FlyBase Human Disease Model Reports Disease Ontology (DO) Annotations Models Based on Experimental Evidence ( 0 ) Allele Disease Evidence References Potential Models Based on Orthology
            ( 0 ) Human Ortholog Disease Evidence References Modifiers Based on Experimental Evidence ( 0 ) Allele Disease Interaction References Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM) Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown. Homo sapiens (Human) Gene name Score OMIM OMIM Phenotype DO term Complementation? Transgene? Functional Complementation Data Functional complementation data is computed by FlyBase using a combination of the orthology data
                  obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the
                  literature. Interactions Summary of Physical Interactions Interaction Browsers Summary of Genetic Interactions Interaction Browsers Starting gene(s) Interaction type Interacting gene(s) Reference Starting gene(s) Interaction type Interacting gene(s) Reference External Data Linkouts Pathways Signaling Pathways (FlyBase) Metabolic Pathways FlyBase External Links External Data Linkouts Class of Gene nuclear_gene ( FlyBase Genome Annotators,  2010 ) protein_coding_gene ( FlyBase Genome Annotators,  2010 ) Genomic Location and Detailed Mapping Data Chromosome (arm) 3R Recombination map 3-95 Cytogenetic map 98C3-98C3 Sequence location 3R:28,263,871..28,264,773 [-] FlyBase Computed Cytological Location Cytogenetic map Evidence for location 98C3-98C3 Experimentally Determined Cytological Location Cytogenetic map Notes References Experimentally Determined Recombination Data Location 3-95 ( FlyBase,  2016 ) 3-93.3 ( Comeron et al.,  2012 ) Left of (cM) Right of (cM) Notes Stocks and Reagents Stocks (0) Aberrations including deletions of this gene Aberrations including duplications of this gene Genomic Clones
            (19) BACR06K21 BACR28F20 CH321-3E12 CH321-35E4 CH321-58A9 CH321-70H11 CH321-70P13 CH321-78J3 CH321-80F3 CH321-85N1 CH321-89K11 CH321-90A11 CH321-93C13 CH321-96M4 CH322-72D5 CH322-121E13 CH322-123L22 CH322-134O15 CH322-186J7 List GenBank IDs Please Note FlyBase no
                        longer curates genomic clone accessions so this list
                        may not be complete cDNA Clones
            (3) List GenBank IDs Clones Consistent with Transcripts Please Note This section lists cDNAs and ESTs that fall within the genomic extent
                        of the gene model, which may include cDNAs and ESTs
                        of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model. cDNA clones, fully sequenced BDGP DGC clones Other clones MIP31574 Drosophila Genomics Resource Center cDNA clones For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged)
                    in several different host vectors for subsequent cloning and expression in Drosophila and
                    Drosophila cell lines. FBgn0262587 cDNA Clones, End Sequenced (ESTs) BDGP DGC clones Other clones EC23623 EC29923 RNAi and Array Information Linkouts Antibody Information Laboratory Generated Antibodies Commercially Available Antibodies Cell Line Information Publicly Available Cell Lines Other Stable Cell Lines Other Comments New annotation (CG43124) in release 5.32 of the genome annotation. ( FlyBase Genome Annotators,  2010 ) Relationship to Other Genes Source for database merge of Additional comments Nomenclature History Source for database identify of Nomenclature comments Etymology Synonyms and Secondary IDs  (2) Reported As Symbol Synonym CG43124 ( Gallo et al.,  2022 , Bischof and FlyORF project members,  2014.6.20 , FlyBase Genome Annotators,  2010 ) SPH249 ( Cao and Jiang,  2018 ) Name Synonyms Secondary FlyBase IDs Datasets (0) Study focus (0) Experimental Role Project Project Type Title Study result (0) Result Result Type Title External Crossreferences and Linkouts ( 18 ) Sequence Crossreferences NCBI Gene -
                  Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide. 12798282 GenBank Protein -
                  A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB. AFH06662 RefSeq -
                  A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein. NM_001260416 NP_001247345 UniProt/GCRP -
                  The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene. A0A0B4K7P3 UniProt/TrEMBL -
                  Automatically annotated and unreviewed records of protein sequence and functional information A0A0B4K7P3 Other crossreferences AlphaFold DB -
                  AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research. A0A0B4K7P3 DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 12798282/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0262587 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0262587 InterPro -
                  A database of protein families, domains and functional sites Serine proteases, trypsin domain Peptidase S1, PA clan Serine/Threonine Proteases with Immune and Developmental Roles KEGG Genes -
                  Molecular building blocks of life in the genomic space. dme:Dmel_CG43124 MARRVEL_MODEL -
                  MARRVEL (model organism gene) 12798282 Linkouts Drosophila Genomics Resource Center -
                  Drosophila Genomics Resource Center (DGRC) cDNA clones FBgn0262587 Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. CG43124_1 FlyCyc Genes -
                  Genes from a BioCyc PGDB for Dmel FBGN0262587 References (8) Report Sections Open Close General Information Genomic Location Function Summaries Gene Model and Products Expression Data Gene ToolKit Alleles, Insertions, Constructs, and Aberrations Classical and Insertion Alleles Transgenic Constructs Aberrations (Deficiencies and Duplications) Variants Phenotypes Orthologs Human Orthologs Model Organism Orthologs Other Organism Orthologs Paralogs Human Disease Associations Functional Complementation Interactions Physical Interaction report Genetic interactions External Data Pathways Class of Gene Genomic Location and Mapping Stocks and Reagents Other Comments Relationship to Other Genes Nomenclature History Synonyms and Secondary IDs Datasets Crossreferences References version FB2026_02, released June 18, 2026 Contact FlyBase FAQ Citing FlyBase