CG45100

Gene Description

CG45100 encodes a predicted 38-residue peptide from an upstream open reading frame associated with the Hdac3 5-prime untranslated region. Its strongly hydrophobic central segment is compatible with membrane insertion, but peptide production, membrane topology, and biological activity are not established.

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0003674 molecular_function	ND GO_REF:0000015	ACCEPT	Summary: Molecular activity is unknown. Reason: The exact 38-residue upstream-ORF product lacks a characterized molecular function; neither its genomic proximity to Hdac3 nor its hydrophobic segment establishes deacetylase activity. Supporting Evidence: file:DROME/CG45100/CG45100-uniprot.txt FT TRANSMEM 12..30 FT /note="Helical" FT /evidence="ECO:0000256\|SAM:Phobius"
GO:0005575 cellular_component	ND GO_REF:0000015	ACCEPT	Summary: Experimental localization is unknown. Reason: Phobius predicts a transmembrane helix at residues 12-30 but this sequence prediction does not establish that the upstream-ORF peptide is produced and localized in vivo. Supporting Evidence: file:DROME/CG45100/CG45100-uniprot.txt FT TRANSMEM 12..30 FT /note="Helical" FT /evidence="ECO:0000256\|SAM:Phobius"
GO:0008150 biological_process	ND GO_REF:0000015	ACCEPT	Summary: Biological process is unknown. Reason: No functional process is established for the exact upstream-ORF peptide. Hdac3 gene function cannot be transferred to a separate 38-residue translation product. Supporting Evidence: file:DROME/CG45100/CG45100-uniprot.txt FT TRANSMEM 12..30 FT /note="Helical" FT /evidence="ECO:0000256\|SAM:Phobius"

References

GO_REF:0000015

Use of the ND evidence code for Gene Ontology (GO) terms

file:DROME/CG45100/CG45100-uniprot.txt

DROME/CG45100/CG45100-uniprot.txt

Deep Research

Falcon

(CG45100-deep-research-falcon.md)

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Manual

(CG45100-deep-research-manual.md)