CG6830 is an 891-residue ecdysteroid-kinase-like family protein containing two CHK-like kinase domains. The arthropod EcKL family has expanded into branches proposed to phosphorylate endogenous steroids or xenobiotic compounds. The physiological substrate and catalytic properties of CG6830 itself remain unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0106389 ecdysteroid 22-kinase activity | TAS PMID:32540344 Genomic and transcriptomic analyses in Drosophila suggest th... | UNDECIDED | Summary: Ecdysteroid 22-phosphorylation is not established for CG6830. Reason: The cited study explicitly proposes a detoxification-kinase hypothesis and analyzes gene-family evolution and expression. The exact target has two CHK-like domains, but those observations neither establish ecdysteroid as its substrate nor prove loss of kinase activity. Target-specific turnover assays are needed to distinguish endogenous steroid phosphorylation from other EcKL chemistry. Supporting Evidence: PMID:32540344 We propose the hypothesis that members of the arthropod-specific ecdysteroid kinase-like (EcKL) gene family encode detoxicative kinases. file:DROME/CG6830/CG6830-uniprot.txt /note="CHK kinase-like" |
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