CG6836 is a seven-pass OST-alpha-family membrane protein with a probable transport role. Its topology and evolutionary placement support membrane integration and a likely cell-surface location. The transported organic solute, partner requirements and physiological role in Drosophila remain unresolved; mammalian bile-acid transport specificity cannot be assumed.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Plasma-membrane residence is a reasonable OST-alpha ortholog inference. Reason: The seven-pass target topology and curated OST-alpha placement support a cell-surface transporter architecture. The location is inferred from homologs rather than measured in fly, and does not identify a bile-acid substrate. Supporting Evidence: file:DROME/CG6836/CG6836-uniprot.txt FT TRANSMEM 45..65 file:DROME/CG6836/CG6836-uniprot.txt Belongs to the OST-alpha family. {ECO:0000305}. |
| GO:0016020 membrane | IEA GO_REF:0000117 | ACCEPT | Summary: Multiple membrane-spanning helices establish membrane integration. Reason: The exact 328-residue product carries seven independently predicted transmembrane segments, consistent with its OST-alpha-family structure. This broad location does not require a mammalian substrate assignment. Supporting Evidence: file:DROME/CG6836/CG6836-uniprot.txt FT TRANSMEM 45..65 file:DROME/CG6836/CG6836-uniprot.txt Belongs to the OST-alpha family. {ECO:0000305}. |
| GO:0016020 membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Multiple membrane-spanning helices establish membrane integration. Reason: The exact 328-residue product carries seven independently predicted transmembrane segments, consistent with its OST-alpha-family structure. This broad location does not require a mammalian substrate assignment. Supporting Evidence: file:DROME/CG6836/CG6836-uniprot.txt FT TRANSMEM 45..65 file:DROME/CG6836/CG6836-uniprot.txt Belongs to the OST-alpha family. {ECO:0000305}. |
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