CG8745 is a 494-residue class-III pyridoxal-phosphate-dependent enzyme related to ethanolamine-phosphate phospho-lyase/AGXT2L proteins. Its major and small PLP-enzyme domains support cofactor-dependent amino-compound metabolism. The precise physiological substrate and intracellular compartment in Drosophila remain unresolved; its historical aminotransferase-like name does not establish conventional aminotransferase activity.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0030170 pyridoxal phosphate binding | IEA GO_REF:0000002 | ACCEPT | Summary: A PLP-dependent catalytic fold supports cofactor binding. Reason: CG8745 retains the major and small class-III PLP-dependent enzyme domains and the PLP attachment-site signature. This supports cofactor binding while leaving physiological substrate specificity distinct from the historical aminotransferase-like name. Supporting Evidence: file:DROME/CG8745/CG8745-uniprot.txt aminotransferase family. {ECO:0000305}. |
| GO:0035094 response to nicotine | IEP PMID:17237783 Quantitative trait transcripts for nicotine resistance in Dr... | UNDECIDED | Summary: The nicotine expression association is not resolved at the target level. Reason: The accessible study reports transcript associations with nicotine resistance and emphasizes ornithine aminotransferase. Its abstract does not identify the CG8745 assay, and the target-specific expression result requires the full gene table. This is not evidence of misattribution and does not establish nicotine metabolism by CG8745. Supporting Evidence: PMID:17237783 We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance. |
| GO:0050459 ethanolamine-phosphate phospho-lyase activity | ISS GO_REF:0000024 | UNDECIDED | Summary: Ethanolamine-phosphate phospho-lyase is a plausible ortholog-based reaction. Reason: The ISS source is human Q8TBG4/ETNPPL, and the target has the corresponding PLP-enzyme architecture. However, broad class-III domain membership and absence of conventional aminotransferase activity alone do not establish phosphoethanolamine turnover by CG8745; the donor biochemical evidence and fly substrate selectivity must be distinguished. Supporting Evidence: file:DROME/CG8745/CG8745-uniprot.txt aminotransferase family. {ECO:0000305}. file:DROME/CG8745/CG8745-uniprot.txt Does not seem to possess aminotransferase activity. |
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