CG8841 is an HID1/Ecm30-family protein associated by phylogenetic and similarity inference with Golgi organization, intracellular protein transport, and secretory-granule maturation. Its likely role is in secretory-pathway membrane organization rather than DNA recombination, despite the historical Dmc1 alias; its molecular activity is unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000138 Golgi trans cisterna | IBA GO_REF:0000033 | ACCEPT | Summary: Trans-Golgi localization is consistent with conserved HID1 biology. Reason: IPR026705 identifies the HID1/Ecm30 family and the IBA locates the protein in the Golgi secretory pathway. No target-specific architectural conflict is apparent. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0003674 molecular_function | ND GO_REF:0000015 | ACCEPT | Summary: Molecular activity remains unresolved. Reason: HID1-family secretory-pathway participation does not establish an intrinsic enzyme activity or a specific binding reaction. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0005794 Golgi apparatus | ISS GO_REF:0000024 | ACCEPT | Summary: Golgi localization is a coherent curated family inference. Reason: The HID1/Ecm30 domain supports the existing ISS Golgi annotation; this is an inferred location rather than a direct fly imaging result. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0005797 Golgi medial cisterna | IBA GO_REF:0000033 | ACCEPT | Summary: Medial-Golgi residence is retained as a curated phylogenetic inference. Reason: The specific IBA is compatible with HID1-family Golgi organization and no target-specific evidence of localization loss is established. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0005829 cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: A cytosolic pool is compatible with peripheral Golgi machinery. Reason: HID1-family membership supports a protein cycling or associating with cytosolic faces of secretory membranes; the curated IBA is retained as an inference rather than direct localization. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0006886 intracellular protein transport | ISS GO_REF:0000024 | ACCEPT | Summary: Intracellular protein transport is consistent with HID1-family biology. Reason: The existing ISS fits the protein's Golgi/secretory-pathway architecture and inferred organization role. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0007030 Golgi organization | IBA GO_REF:0000033 | ACCEPT | Summary: Golgi organization is a reasonable core family-level process. Reason: The HID1/Ecm30-family assignment is coherent with the curated IBA Golgi-organization assertion and does not require catalytic activity. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0016020 membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Membrane association is compatible with a peripheral Golgi factor. Reason: A retained transmembrane helix is not required for peripheral membrane association; HID1-family biology and the existing IBA support the broad membrane term. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
| GO:0061792 secretory granule maturation | IBA GO_REF:0000033 | ACCEPT | Summary: Secretory-granule maturation is retained as a curated family inference. Reason: HID1-family placement is consistent with a role in Golgi-dependent maturation of secretory cargo. The evidence establishes participation by phylogenetic inference rather than an intrinsic catalytic mechanism. Supporting Evidence: file:DROME/CG8841/CG8841-uniprot.txt DR InterPro; IPR026705; HID1/Ecm30. |
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