id: Q9VX63
gene_symbol: CG8915
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The broad nucleic-acid-binding prediction is supported and less precise than RNA binding.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/CG8915/CG8915-predictions-source.json
references:
- id: file:DROME/CG8915/CG8915-bioinformatics/RESULTS.md
  title: DROME/CG8915/CG8915-bioinformatics/RESULTS.md
  findings: []
- id: file:DROME/CG8915/CG8915-uniprot.txt
  title: DROME/CG8915/CG8915-uniprot.txt
  findings: []
- id: PMID:29033321
  title: Regulation of m(6)A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful
    Meiotic Program in the Mammalian Germline.
  full_text_unavailable: true
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0003676
    label: nucleic acid binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: Nucleic acid binding is supported by the R3H domain and conserved RNA-helicase architecture.
      RNA binding is the existing, more specific assignment. Target sequence analysis retains the ATP-binding
      and DEAH motifs, although the broad RNA-binding conclusion does not depend on resolving every aspect
      of catalysis or YTHDC2-family phylogeny.
    supported_by:
    - reference_id: file:DROME/CG8915/CG8915-bioinformatics/RESULTS.md
      supporting_text: CG8915/Q9VX63 retains a canonical ATP-binding P-loop and DEAH catalytic motif.
        It differs from the inactive helicase-like protein Bgcn/Q9W1I2 at both diagnostic regions.
    - reference_id: file:DROME/CG8915/CG8915-uniprot.txt
      supporting_text: DR   InterPro; IPR001374; R3H_dom.
    - reference_id: PMID:29033321
      supporting_text: 'Our biochemical studies indicate that YTHDC2 is an

        RNA-induced ATPase with a 3''→5'' RNA helicase activity.'