id: A0A0B4KHM2
gene_symbol: CSN5
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: CSN5 has a supported signalosome catalytic role, but synaptic-vesicle localization is unverified
  for the selected PB isoform.
source_documents:
- genes/DROME/CSN5/CSN5-protnlm-source.json
- genes/DROME/CSN5/CSN5-bioinformatics/RESULTS.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CSN5/CSN5-protnlm-source.json
  predicted_term:
    id: GO:0008021
    label: synaptic vesicle
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: The target is a near-identical CSN5 splice product retaining the complete JAMM catalytic
      domain. Primary evidence establishes the COP9 deneddylation mechanism, including roles in neural
      development, but those processes do not establish physical residence in synaptic vesicles. The source
      donor Q6GLM9 is a homologous protein and its compartment label is not a substitute for target vesicle
      localization. No vesicle-specific microscopy, fractionation or supported conserved vesicle-targeting
      feature validates or refutes the claim. The term is absent from target GOA.
    supported_by:
    - reference_id: file:DROME/CSN5/CSN5-bioinformatics/RESULTS.md
      supporting_text: The MPN domain 52–189 and JAMM motif 135–148 are completely retained, including
        His135, His137 and Asp148.
    - reference_id: PMID:12183637
      supporting_text: 'The Jab1/MPN domain metalloenzyme (JAMM) motif

        in the Jab1/Csn5 subunit was found to underlie CSN''s Nedd8 isopeptidase

        activity.'
references:
- id: file:DROME/CSN5/CSN5-bioinformatics/RESULTS.md
  title: RESULTS.md
  findings: []
- id: PMID:12183637
  title: Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.
  findings: []