Cables1 is a cyclin-fold protein required for the organization of sensory and motile cilia in Drosophila. It is recruited to maturing sperm basal bodies, and its loss disrupts neuronal ciliary architecture and the central pair of sperm axonemal microtubules. Its molecular activity at the basal body remains unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0036064 ciliary basal body | IDA PMID:37317646 A phylogenetic profiling approach identifies novel ciliogene... | ACCEPT | Summary: Basal-body localization is directly observed. Reason: GFP-tagged Cables1 is recruited to maturing basal bodies during spermatogenesis in the full-text analysis of PMID:37317646; the relatively faint signal does not negate the localization. Supporting Evidence: PMID:37317646 TEX9, CCDC6, and CABLES1 are recruited to maturing basal bodies during Drosophila spermatogenesis. |
| GO:0044458 motile cilium assembly | IMP PMID:37317646 A phylogenetic profiling approach identifies novel ciliogene... | ACCEPT | Summary: Cables1 participates in motile cilium assembly. Reason: Depletion and deletion produce sperm axonemal defects including loss of the central pair in PMID:37317646; this is a direct ciliogenesis phenotype. Supporting Evidence: PMID:37317646 RNAi‐mediated depletion/deletion of CABLES1, CCDC6, CEP104, and TEX9 in Drosophila chordotonal neurons (A) and sperm (B) results in defects in ciliary ultrastructure similar to CEP135. |
| GO:0051726 regulation of cell cycle | IEA GO_REF:0000002 | UNDECIDED | Summary: A cyclin fold does not establish a cell-cycle function in fly. Reason: IPR012388 establishes CABLES-family membership, and the InterPro2GO mapping transfers a cell-cycle role that rests on mammalian CABLES1/CABLES2 (CDK-associated anti-proliferative regulators). Fly Cables1 sits in PANTHER subfamily PTHR22896:SF0 together with the uncharacterized C. elegans Y71F9B.6, outside the vertebrate CABLES1 (SF1) and CABLES2 (SF3/SF4) subfamilies, and PAINT has propagated no IBA term to it. The only direct fly experiments (PMID:37317646) place it at basal bodies and implicate it in axoneme architecture; no fly study tests CDK binding or cell-cycle progression. The term is neither supported nor contradicted for this product, so it is left undecided rather than removed. Supporting Evidence: file:DROME/Cables1/Cables1-uniprot.txt DR InterPro; IPR012388; CABLES1/2. file:DROME/Cables1/Cables1-uniprot.txt DR InterPro; IPR036915; Cyclin-like_sf. file:DROME/Cables1/Cables1-uniprot.txt FT DOMAIN 621..699 FT /note="Cyclin N-terminal" FT /evidence="ECO:0000259|Pfam:PF00134" PMID:37317646 TEX9, CCDC6, and CABLES1 are recruited to maturing basal bodies during Drosophila spermatogenesis. PMID:37317646 RNAi‐mediated depletion/deletion of CABLES1, CCDC6, CEP104, and TEX9 in Drosophila chordotonal neurons |
| GO:1905515 non-motile cilium assembly | IMP PMID:37317646 A phylogenetic profiling approach identifies novel ciliogene... | ACCEPT | Summary: Cables1 participates in sensory-cilium assembly. Reason: Neuronal cilia show disorganization and shortened axonemes after Cables1 loss in PMID:37317646; the developmental assembly role is supported. Supporting Evidence: PMID:37317646 RNAi‐mediated depletion/deletion of CABLES1, CCDC6, CEP104, and TEX9 in Drosophila chordotonal neurons (A) and sperm (B) results in defects in ciliary ultrastructure similar to CEP135. |
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