id: Q9VF20
gene_symbol: Hmt-1
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The broad ABC transporter prediction is supported and less specific than the conserved ABCB6-family
  heme-transport capability.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/Hmt-1/Hmt-1-predictions-source.json
references:
- id: PMID:19001374
  title: Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog,
    SpHMT-1, are not essential for vacuolar phytochelatin sequestration.
  full_text_unavailable: true
  findings: []
- id: file:DROME/Hmt-1/Hmt-1-uniprot.txt
  title: DROME/Hmt-1/Hmt-1-uniprot.txt
  findings: []
- id: PMID:35950458
  title: Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter
    ABCB6.
  full_text_unavailable: false
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0140359
    label: ABC-type transporter activity
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: ABC-type transport is supported by the target ABCB6 architecture and functional rescue of
      the fission-yeast hmt-1 cadmium-sensitivity phenotype. The existing ABC-type heme transporter activity
      is more specific and has a justified ABCB6-family basis in hemin-bound structures, although the
      relative physiological substrate use in the fly remains unresolved. The broad prediction is biologically
      supported independently of the many unverified compartment assignments.
    supported_by:
    - reference_id: PMID:19001374
      supporting_text: 'heterologously expressed DmHMT-1

        suppresses the Cd2+ hypersensitivity of S. pombe hmt-1 mutants and localizes to

        the vacuolar membrane but does not transport Cd.PC complexes.'
    - reference_id: file:DROME/Hmt-1/Hmt-1-uniprot.txt
      supporting_text: DR   InterPro; IPR032410; ABCB6_N.
    - reference_id: file:DROME/Hmt-1/Hmt-1-uniprot.txt
      supporting_text: DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
    - reference_id: PMID:35950458
      supporting_text: 'Here we report the cryo-electron microscopy (cryo-EM) structures

        of human ABCB6 with its substrates, coproporphyrin III (CPIII) and hemin, at 3.5

        and 3.7 Å resolution, respectively.'