id: Q9V3Y8
gene_symbol: IKKepsilon
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Protein phosphorylation is directly established by experiments on fly Ik2 substrates Spn-F,
  Nuf and DIAP1.
source_documents:
- genes/DROME/IKKepsilon/IKKepsilon-predictions-source.json
- genes/DROME/IKKepsilon/IKKepsilon-uniprot-source.json
references:
- id: PMID:16887178
  title: Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of
    IAPs.
  findings: []
  full_text_unavailable: true
- id: PMID:18796167
  title: The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates
    cytoskeleton organization during oogenesis.
  findings: []
  full_text_unavailable: false
- id: PMID:21316589
  title: IKKε regulates cell elongation through recycling endosome shuttling.
  findings: []
  full_text_unavailable: true
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/IKKepsilon/IKKepsilon-predictions-source.json
  predicted_term:
    id: GO:0006468
    label: protein phosphorylation
  predicted_term_type: GO_BP
  review:
    assessment: CNN
    confidence_score: 2
    summary: Protein phosphorylation is directly established by experiments on fly Ik2 substrates Spn-F,
      Nuf and DIAP1. The selected Q9V3Y8 protein retains the complete kinase domain, and the broad reaction
      is already captured by experimentally supported serine/threonine kinase annotations. This is an
      equivalent known biological activity rather than a novel claim. It does not entail every mammalian
      TBK1 downstream pathway, particularly interferon production.
    supported_by:
    - reference_id: PMID:18796167
      supporting_text: We showed that Ik2 phosphorylates Spn-F and demonstrated that this phosphorylation
        does not lead to Spn-F degradation.
    - reference_id: PMID:21316589
      supporting_text: IKKɛ regulates the localization of recycling endosome regulators Rab11 and Dynein
        and phosphorylates their adaptor molecule, Nuclear fallout (Nuf).
    - reference_id: PMID:16887178
      supporting_text: We show that DmIKKvarepsilon promotes degradation of DIAP1 through direct phosphorylation.