DEPDC5/Iml1 GATOR1 subunit that suppresses TORC1 to control meiotic entry and oocyte development.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0010508 positive regulation of autophagy | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Iml1 supports autophagy during nutrient stress via TORC1 inhibition. Reason: UniProt notes GATOR1 promotes survival under starvation by promoting autophagy. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy |
| GO:0034198 cellular response to amino acid starvation | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway |
| GO:1904262 negative regulation of TORC1 signaling | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway |
| GO:0005765 lysosomal membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Lysosomal membrane association is consistent with GATOR localization at lysosomes. Reason: GATOR complex functions at the lysosome in nutrient sensing; Iml1 is a GATOR1 subunit. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 |
| GO:1990130 GATOR1 complex | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 is a core subunit of the GATOR1 complex. Reason: UniProt annotates Iml1 as a probable GATOR1 subcomplex component. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 file:genes/DROME/Iml1/Iml1-deep-research-falcon.md Iml1 encodes the Drosophila melanogaster ortholog of yeast Sea1 and human DEPDC5, forming the catalytic/scaffold subunit of the GATOR1 complex with Nprl2 and Nprl3. |
| GO:0005096 GTPase activator activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: GATOR1 has Rag GTPase GAP activity; Iml1 is a GATOR1 subunit. Reason: GTPase-activating activity is established for GATOR1 (RagA/B), so the IEA/ISS is reasonable for Iml1 but not the primary focus. Supporting Evidence: PMID:23723238 GATOR1 has GTPase-activating protein (GAP) activity for RagA and RagB |
| GO:0051301 cell division | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: General cell division is too broad relative to the specific mitotic-to-meiotic transition role. Reason: Evidence indicates a specific mitotic/meiotic transition control rather than broad cell division. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition |
| GO:0051321 meiotic cell cycle | IEA GO_REF:0000043 | MODIFY | Summary: Meiotic cell cycle is captured more precisely by germline mitotic-to-meiotic switching. Reason: Use the more specific germline cell cycle switching term supported by ovarian cyst data. Proposed replacements: germline cell cycle switching, mitotic to meiotic cell cycle Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition |
| GO:0034198 cellular response to amino acid starvation | NAS PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive res... | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | NAS PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive res... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. |
| GO:0005764 lysosome | IDA PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | KEEP AS NON CORE | Summary: Iml1 localizes to lysosomes as part of the GATOR complex. Reason: GATOR complex functions at the lysosome in nutrient sensing; Iml1 is a GATOR1 subunit. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1 promotes the mitotic-to-meiotic transition in germline cysts via TORC1 inhibition. Reason: GATOR1 members down-regulate TORC1 to promote the mitotic/meiotic transition. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle | IGI PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1 promotes the mitotic-to-meiotic transition in germline cysts via TORC1 inhibition. Reason: GATOR1 members down-regulate TORC1 to promote the mitotic/meiotic transition. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | IMP PMID:27672113 The GATOR1 Complex Regulates Metabolic Homeostasis and the R... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:27672113 The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster. |
| GO:0035859 Seh1-associated complex | IDA PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | MODIFY | Summary: The SEA/GATOR complex term is broader than the specific GATOR1 complex membership. Reason: Evidence supports GATOR1 subcomplex membership; use the specific GATOR1 complex term. Proposed replacements: GATOR1 complex Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:1990130 GATOR1 complex | TAS PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | ACCEPT | Summary: Iml1 is a core subunit of the GATOR1 complex. Reason: UniProt annotates Iml1 as a probable GATOR1 subcomplex component. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:0032007 negative regulation of TOR signaling | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | MODIFY | Summary: This term is too general for the specific TORC1 inhibition shown for Iml1. Reason: Evidence supports inhibition of TORC1 specifically; replace with the TORC1-specific term. Proposed replacements: negative regulation of TORC1 signaling Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0034198 cellular response to amino acid starvation | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0045792 negative regulation of cell size | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | KEEP AS NON CORE | Summary: Iml1 restrains TORC1-dependent cell growth, consistent with negative regulation of cell size. Reason: GATOR1 inhibition of TORC1-dependent growth supports reduced cell size/growth phenotypes. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt inhibiting TORC1-dependent cell growth PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0048142 germarium-derived cystoblast division | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1/GATOR1 regulates the mitotic divisions of germline cysts prior to meiotic entry. Reason: Loss of GATOR1 causes ovarian cysts to undergo extra mitotic divisions before meiosis. Supporting Evidence: PMID:25512509 ovarian cysts undergo an extra mitotic division before meiotic entry |
| GO:0005096 GTPase activator activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: GATOR1 has Rag GTPase GAP activity; Iml1 is a GATOR1 subunit. Reason: GTPase-activating activity is established for GATOR1 (RagA/B), so the IEA/ISS is reasonable for Iml1 but not the primary focus. Supporting Evidence: PMID:23723238 GATOR1 has GTPase-activating protein (GAP) activity for RagA and RagB |
| GO:0035859 Seh1-associated complex | ISS PMID:21454883 A conserved coatomer-related complex containing Sec13 and Se... | MODIFY | Summary: The SEA/GATOR complex term is broader than the specific GATOR1 complex membership. Reason: Evidence supports GATOR1 subcomplex membership; use the specific GATOR1 complex term. Proposed replacements: GATOR1 complex Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 PMID:21454883 A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. |
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