DEPDC5/Iml1 GATOR1 subunit that suppresses TORC1 to control meiotic entry and oocyte development.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0010508 positive regulation of autophagy | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Iml1 supports autophagy during nutrient stress via TORC1 inhibition. Reason: UniProt notes GATOR1 promotes survival under starvation by promoting autophagy. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy |
| GO:0034198 cellular response to amino acid starvation | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway |
| GO:1904262 negative regulation of TORC1 signaling | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway |
| GO:0005765 lysosomal membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Lysosomal membrane association is consistent with GATOR localization at lysosomes. Reason: GATOR complex functions at the lysosome in nutrient sensing; Iml1 is a GATOR1 subunit. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 |
| GO:1990130 GATOR1 complex | IBA GO_REF:0000033 | ACCEPT | Summary: Iml1 is a core subunit of the GATOR1 complex. Reason: UniProt annotates Iml1 as a probable GATOR1 subcomplex component. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 file:genes/DROME/Iml1/Iml1-deep-research-falcon.md Iml1 encodes the Drosophila melanogaster ortholog of yeast Sea1 and human DEPDC5, forming the catalytic/scaffold subunit of the GATOR1 complex with Nprl2 and Nprl3. |
| GO:0005096 GTPase activator activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: GATOR1 has Rag GTPase GAP activity; Iml1 is a GATOR1 subunit. Reason: GTPase-activating activity is established for GATOR1 (RagA/B), so the IEA/ISS is reasonable for Iml1 but not the primary focus. Supporting Evidence: PMID:23723238 GATOR1 has GTPase-activating protein (GAP) activity for RagA and RagB |
| GO:0051301 cell division | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: General cell division is too broad relative to the specific mitotic-to-meiotic transition role. Reason: Evidence indicates a specific mitotic/meiotic transition control rather than broad cell division. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition |
| GO:0051321 meiotic cell cycle | IEA GO_REF:0000043 | MODIFY | Summary: Meiotic cell cycle is captured more precisely by germline mitotic-to-meiotic switching. Reason: Use the more specific germline cell cycle switching term supported by ovarian cyst data. Proposed replacements: germline cell cycle switching, mitotic to meiotic cell cycle Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition |
| GO:0034198 cellular response to amino acid starvation | NAS PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive res... | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | NAS PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive res... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. |
| GO:0005764 lysosome | IDA PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | KEEP AS NON CORE | Summary: Iml1 localizes to lysosomes as part of the GATOR complex. Reason: GATOR complex functions at the lysosome in nutrient sensing; Iml1 is a GATOR1 subunit. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1 promotes the mitotic-to-meiotic transition in germline cysts via TORC1 inhibition. Reason: GATOR1 members down-regulate TORC1 to promote the mitotic/meiotic transition. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle | IGI PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1 promotes the mitotic-to-meiotic transition in germline cysts via TORC1 inhibition. Reason: GATOR1 members down-regulate TORC1 to promote the mitotic/meiotic transition. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. |
| GO:1904262 negative regulation of TORC1 signaling | IMP PMID:27672113 The GATOR1 Complex Regulates Metabolic Homeostasis and the R... | ACCEPT | Summary: Iml1 inhibits TORC1 signaling as part of GATOR1. Reason: UniProt describes GATOR1 as an inhibitor of the amino acid-sensing branch of TORC1. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:27672113 The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster. |
| GO:0035859 Seh1-associated complex | IDA PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | MODIFY | Summary: The SEA/GATOR complex term is broader than the specific GATOR1 complex membership. Reason: Evidence supports GATOR1 subcomplex membership; use the specific GATOR1 complex term. Proposed replacements: GATOR1 complex Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:1990130 GATOR1 complex | TAS PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lyso... | ACCEPT | Summary: Iml1 is a core subunit of the GATOR1 complex. Reason: UniProt annotates Iml1 as a probable GATOR1 subcomplex component. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 PMID:27166823 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. |
| GO:0032007 negative regulation of TOR signaling | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | MODIFY | Summary: This term is too general for the specific TORC1 inhibition shown for Iml1. Reason: Evidence supports inhibition of TORC1 specifically; replace with the TORC1-specific term. Proposed replacements: negative regulation of TORC1 signaling Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0034198 cellular response to amino acid starvation | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | ACCEPT | Summary: Iml1 participates in the response to amino-acid starvation via GATOR1. Reason: GATOR1 inhibition of TORC1 is central to the amino-acid starvation response. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0045792 negative regulation of cell size | IMP PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTP... | KEEP AS NON CORE | Summary: Iml1 restrains TORC1-dependent cell growth, consistent with negative regulation of cell size. Reason: GATOR1 inhibition of TORC1-dependent growth supports reduced cell size/growth phenotypes. Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt inhibiting TORC1-dependent cell growth PMID:23723238 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. |
| GO:0048142 germarium-derived cystoblast division | IMP PMID:25512509 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entr... | KEEP AS NON CORE | Summary: Iml1/GATOR1 regulates the mitotic divisions of germline cysts prior to meiotic entry. Reason: Loss of GATOR1 causes ovarian cysts to undergo extra mitotic divisions before meiosis. Supporting Evidence: PMID:25512509 ovarian cysts undergo an extra mitotic division before meiotic entry |
| GO:0005096 GTPase activator activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: GATOR1 has Rag GTPase GAP activity; Iml1 is a GATOR1 subunit. Reason: GTPase-activating activity is established for GATOR1 (RagA/B), so the IEA/ISS is reasonable for Iml1 but not the primary focus. Supporting Evidence: PMID:23723238 GATOR1 has GTPase-activating protein (GAP) activity for RagA and RagB |
| GO:0035859 Seh1-associated complex | ISS PMID:21454883 A conserved coatomer-related complex containing Sec13 and Se... | MODIFY | Summary: The SEA/GATOR complex term is broader than the specific GATOR1 complex membership. Reason: Evidence supports GATOR1 subcomplex membership; use the specific GATOR1 complex term. Proposed replacements: GATOR1 complex Supporting Evidence: file:genes/DROME/Iml1/Iml1-uniprot.txt Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 PMID:21454883 A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. |
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Download this section (compressed HTML)Increased minichromosome loss 1 (Iml1) encodes a component of the highly conserved GAP Activity Towards Rags 1 (GATOR1) complex, which inhibits the activity of the product of mTor in response to amino acid starvation. The product of Iml1, as well as the other GATOR1 components encoded by Nprl2 and Nprl3, regulates early meiotic progression.
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