id: A0A0B4KEF3
gene_symbol: Lcp3
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: >-
  ProtNLM2 emitted no GO or EC predictions for A0A0B4KEF3 in the frozen
  2026-09-08 API snapshot. It emitted a protein name, a Secreted location,
  and the function text "Component of the rigid cuticle of the spider".
  The absence of GO output is an informative coverage omission: the current
  target is identical over all 112 residues to reviewed Lcp3 P07188 at the
  same FlyBase locus, which has experimental FlyBase annotations for
  GO:0008010 structural constituent of chitin-based larval cuticle and
  GO:0062129 chitin-based extracellular matrix. These are well-supported
  expected functions, not predictions emitted by ProtNLM. The separate
  function-description review supports the broad cuticle claim, leaves the
  rigid qualifier uncertain, and rejects the spider attribution. This record
  assesses missing GO output without assigning a VDCL score to an absent
  prediction or asserting a benchmark-wide recall value; the prediction-time
  input sequence and training-set membership remain unknown.
source_documents:
  - genes/DROME/Lcp3/Lcp3-protnlm-source.json
  - genes/DROME/Lcp3/Lcp3-protnlm-function-review.md
  - genes/DROME/Lcp3/Lcp3-bioinformatics/RESULTS.md
  - genes/DROME/Lcp3/Lcp3-reference-P07188-uniprot.txt
predictions: []
references:
  - id: file:DROME/Lcp3/Lcp3-protnlm-source.json
    title: Frozen ProtNLM2 API response for A0A0B4KEF3, retrieved 2026-09-08
    findings:
      - statement: >-
          The response contains function text, a protein name, and a subcellular
          location, but no GO cross-references or EC predictions.
        supporting_text: Component of the rigid cuticle of the spider
  - id: file:DROME/Lcp3/Lcp3-bioinformatics/RESULTS.md
    title: Lcp3 current accession sequence comparison
    findings:
      - statement: >-
          Current exact sequence identity and shared locus support applying
          the reviewed Lcp3 functional evidence to the selected accession.
        supporting_text: >-
          The selected A0A0B4KEF3 sequence is identical to reviewed Lcp3 P07188:
          112 of 112 residues match without gaps. Both records map to FlyBase
          FBgn0002534 and RefSeq NP_001260803.1 / NP_476621.1.
  - id: file:DROME/Lcp3/Lcp3-reference-P07188-uniprot.txt
    title: Reviewed UniProtKB P07188 Lcp3 record
    findings:
      - statement: >-
          FlyBase experimentally annotates the identical reviewed protein to
          the larval-cuticle structural function and extracellular cuticle matrix.
        supporting_text: >-
          DR   GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
          DR   GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.