N (Notch) encodes the single Drosophila Notch receptor, a large single-pass type I transmembrane protein with 36 extracellular EGF-like repeats, three Lin-12/Notch repeats, a transmembrane region and an intracellular domain with a RAM region, ankyrin repeats and a C-terminal PEST region. EGF repeats 11-12 bind the DSL ligands Delta and Serrate presented on neighboring cells; ligand binding and endocytic pulling expose the receptor to ADAM (Kuzbanian) S2 cleavage and gamma-secretase (Presenilin) S3 cleavage, releasing the Notch intracellular domain (NICD). NICD enters the nucleus, binds the CSL DNA-binding factor Su(H) and recruits Mastermind to activate transcription of Enhancer of split and other target genes. Receptor activity is modulated by O-fucosylation (Ofut1), O-glucosylation (Rumi), Fringe-mediated GlcNAc elongation, cis-inhibition by ligands, and ubiquitin-dependent endocytic trafficking and lysosomal degradation (Deltex, Su(dx)/Nedd4, Cbl, ESCRT). Notch signaling controls lateral inhibition during neurogenesis and sensory organ development, boundary formation (wing margin), and numerous other cell-fate, proliferation and stem-cell decisions throughout development.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001708 cell fate specification | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'cell fate specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0001745 compound eye morphogenesis | IMP PMID:14702038 Growth and specification of the eye are controlled independe... | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14702038 We present evidence that the organizing signal Notch does not promote growth in eyes of D. melanogaster through either Eyeless (Ey) or Twin of eyeless (Toy), the two Pax6 transcription factors |
| GO:0001745 compound eye morphogenesis | IMP PMID:16039641 Notch signaling controls proliferation through cell-autonomo... | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16039641 Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye |
| GO:0001745 compound eye morphogenesis | IMP PMID:18166433 Cellular behavior in the developing Drosophila pupal retina. | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:18166433 We also analyzed two mutants affecting eye patterning and demonstrate that cells mutant for Notch or Roughest signaling were aberrantly dynamic in their cell movements |
| GO:0001745 compound eye morphogenesis | IMP PMID:2792755 Notch is required for successive cell decisions in the devel... | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:2792755 Notch is required for successive cell decisions in the developing Drosophila retina |
| GO:0001745 compound eye morphogenesis | IMP PMID:8413612 An activated Notch receptor blocks cell-fate commitment in t... | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:8413612 The Notch locus of Drosophila melanogaster encodes a 2,703-amino-acid transmembrane protein required for a variety of developmental processes, including neurogenesis, oogenesis and ommatidial assembly |
| GO:0002052 positive regulation of neuroblast proliferation | IMP PMID:17182870 Aurora-A acts as a tumor suppressor and regulates self-renew... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17182870 To test whether Notch might be hyperactivated in aurA mutants, we examined the membrane localization of Sanpodo (Spdo), which is required to activate Notch but is inhibited by Numb during GMC and SOP asymmetric divisions ( OβConnor-Giles and Skeath 2003 ; Le Borgne et al. 2005 ) |
| GO:0002052 positive regulation of neuroblast proliferation | IMP PMID:22357926 bHLH-O proteins are crucial for Drosophila neuroblast self-r... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:22357926 22. bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation |
| GO:0002052 positive regulation of neuroblast proliferation | IMP PMID:23056424 The bHLH repressor Deadpan regulates the self-renewal and sp... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:23056424 Second, we examined whether lowering Notch expression enhances the loss of type II NBs in dpn7 heterozygous larval brains. dpn7 heterozygous mutant larvae contained a slightly reduced number of type II NBs (about 6 per brain lobe) (Fig. 8C), thus providing a sensitized genetic background |
| GO:0002052 positive regulation of neuroblast proliferation | IMP PMID:28520736 The bantam microRNA acts through Numb to exert cell growth c... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28520736 Notch (N) signaling is central to the self-renewal of neural stem cells (NSCs) and other tissue stem cells |
| GO:0002164 larval development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'larval development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0002213 defense response to insect | IDA PMID:24318532 An unexpected link between notch signaling and ROS in restri... | KEEP AS NON CORE | Summary: N IDA annotation to 'defense response to insect'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:24318532 Here we address the role of Notch (N) signaling in lamellocyte differentiation in response to wasp infection |
| GO:0003682 chromatin binding | IDA PMID:16763555 An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) r... | KEEP AS NON CORE | Summary: ChIP shows NICD recruited to Su(H)-binding sites in the chn and E(spl)m-delta promoters in eye discs. Reason: NICD association with chromatin is indirect, via DNA-bound Su(H); it is a consequence of the coactivator function rather than an independent chromatin-binding activity. Kept as non-core. Supporting Evidence: PMID:16763555 Using the antibody against NICD, we showed that NICD is indeed recruited to the promoter region of E(spl)m Ξ΄,which is shown to be a target site of NICD/Su(H) in the eye imaginal disc ( Cooper and Bray, 1999 ; Figure 4A ) |
| GO:0003713 transcription coactivator activity | IDA PMID:11390662 A human protein with sequence similarity to Drosophila maste... | ACCEPT | Summary: The released Notch intracellular domain (NICD) acts as a transcriptional coactivator with Su(H)/CSL and Mastermind at Notch-responsive enhancers. Reason: NICD has no DNA-binding activity of its own; it binds Su(H) via the RAM domain and ankyrin repeats and, together with Mastermind, converts Su(H) from a repressor into an activator of E(spl) genes. Transcription coactivator activity accurately describes the nuclear function of the processed receptor. Supporting Evidence: PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. These results indicate that Mam is an essential component of the transcriptional apparatus of Notch signaling PMID:8749394 In vitro interaction studies, using proteins fused to glutathione-S-transferase, showed that RBP-J kappa and Su(H) bind directly to the RAM23 regions of mouse Notch1 and Drosophila Notch, respectively. |
| GO:0004888 transmembrane signaling receptor activity | IDA PMID:15611340 The adhesion force of Notch with Delta and the rate of Notch... | ACCEPT | Summary: Notch is a single-pass type I transmembrane receptor for the membrane-bound ligands Delta and Serrate. Reason: Notch binds Delta and Serrate via EGF repeats 11-12 and transduces the signal across the membrane; both ectodomain and intracellular domain are required for signaling-competent adhesion with Delta. This is the core receptor molecular function. Supporting Evidence: PMID:15611340 Using atomic force microscopy on live cells, chemical inhibitors, and conventional analyses, we show that the rate of Notch signaling is linked to the adhesion force between cells expressing Notch receptors and Delta ligand PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. file:DROME/N/N-deep-research-falcon.md This region functions as an autoinhibitory module that masks the S2 protease cleavage site |
| GO:0005509 calcium ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Calcium ion binding inferred from EGF-like calcium-binding domains (InterPro). Reason: The 36 EGF repeats of the Notch ectodomain include many calcium-binding EGF modules, and calcium binding is structurally important for ectodomain rigidity and ligand binding; it is a structural property supporting receptor function rather than the core activity. Supporting Evidence: PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0005515 protein binding | IPI PMID:10935637 Glycosyltransferase activity of Fringe modulates Notch-Delta... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:10935637 Glycosyltransferase activity of Fringe modulates Notch-Delta interactions |
| GO:0005515 protein binding | IPI PMID:11861487 Involvement of a proline-rich motif and RING-H2 finger of De... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:11861487 The Drosophila deltex gene regulates Notch signaling in a positive manner, and its gene product physically interacts with the intracellular domain of Notch through its N-terminal domain |
| GO:0005515 protein binding | IPI PMID:11861487 Involvement of a proline-rich motif and RING-H2 finger of De... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:11861487 The Drosophila deltex gene regulates Notch signaling in a positive manner, and its gene product physically interacts with the intracellular domain of Notch through its N-terminal domain |
| GO:0005515 protein binding | IPI PMID:12919675 Numb inhibits membrane localization of Sanpodo, a four-pass ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:12919675 We demonstrate that sanpodo, which specifies the Notch-dependent fate (A), encodes a four-pass transmembrane protein that localizes to the cell membrane in the A cell and physically interacts with the Notch receptor |
| GO:0005515 protein binding | IPI PMID:15611340 The adhesion force of Notch with Delta and the rate of Notch... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:15611340 The differences in interactions with Dl are expected to be due to the differences in the number of Notch receptors binding Dl, the strength of each one of these bindings, and other Notch-specific aspects affecting these two factors (protein modifications, multimerization, ratio of functioning to defective molecules, rate of signaling or turnover, etc.) |
| GO:0005515 protein binding | IPI PMID:15620649 Drosophila Nedd4 regulates endocytosis of notch and suppress... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:15620649 In tissue culture cells, the dominant-negative form of Nedd4 blocks steady-state Notch internalization and activates Notch signaling independently of ligand binding |
| GO:0005515 protein binding | IPI PMID:15620649 Drosophila Nedd4 regulates endocytosis of notch and suppress... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:15620649 In tissue culture cells, the dominant-negative form of Nedd4 blocks steady-state Notch internalization and activates Notch signaling independently of ligand binding |
| GO:0005515 protein binding | IPI PMID:15620650 Regulation of notch endosomal sorting and signaling by Droso... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:15620650 Upon binding to its ligands, Delta (Dl) or Serrate (Ser), the Notch ectodomain is shed by the action of an ADAM protease |
| GO:0005515 protein binding | IPI PMID:16271883 Structure and Notch receptor binding of the tandem WWE domai... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:16271883 Structure and Notch receptor binding of the tandem WWE domain of Deltex |
| GO:0005515 protein binding | IPI PMID:17183697 The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingles... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:17183697 The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled |
| GO:0005515 protein binding | IPI PMID:17212657 Polarized exocytosis and transcytosis of Notch during its ap... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:17212657 Notch (N) and its ligands, Delta (Dl) and Serrate (Ser), are transmembrane proteins that mediate the cell-cell interactions necessary for many cell-fate decisions |
| GO:0005515 protein binding | IPI PMID:17535912 Conformational variability of the intracellular domain of Dr... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:17535912 This interaction appears to involve Notch binding sites that overlap with those mediating the interaction between NICD and the cytoplasmic Notch signal modulator, Deltex ( 5 , 6 ) |
| GO:0005515 protein binding | IPI PMID:17535912 Conformational variability of the intracellular domain of Dr... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:17535912 This interaction appears to involve Notch binding sites that overlap with those mediating the interaction between NICD and the cytoplasmic Notch signal modulator, Deltex ( 5 , 6 ) |
| GO:0005515 protein binding | IPI PMID:17656366 Specificity and autoregulation of Notch binding by tandem WW... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:17656366 WW4 Displays Greatest Affinity and Selectivity for the Notch-PY SequenceHaving identified direct interactions between Su(dx) WW domains and the Notch PY motif, isothermal titration calorimetry (ITC) was used to obtain quantitative measurements of binding affinity between the domains and Notch peptides containing the motif |
| GO:0005515 protein binding | IPI PMID:20203305 Gene deletion screen for cardiomyopathy in adult Drosophila ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:20203305 After ligand binding, presenilin proteins mediate proteolytic cleavage of the Notch Intracellular domain (NICD) 21, 23 |
| GO:0005515 protein binding | IPI PMID:20203305 Gene deletion screen for cardiomyopathy in adult Drosophila ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:20203305 After ligand binding, presenilin proteins mediate proteolytic cleavage of the Notch Intracellular domain (NICD) 21, 23 |
| GO:0005515 protein binding | IPI PMID:20203305 Gene deletion screen for cardiomyopathy in adult Drosophila ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:20203305 After ligand binding, presenilin proteins mediate proteolytic cleavage of the Notch Intracellular domain (NICD) 21, 23 |
| GO:0005515 protein binding | IPI PMID:21765394 Insensitive is a corepressor for Suppressor of Hairless and ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:21765394 Abstract The Notch intracellular domain functions as a co-activator for the DNA-binding protein Suppressor of Hairless (Su(H)) to mediate myriad cell fate decisions |
| GO:0005515 protein binding | IPI PMID:23609534 Sanpodo controls sensory organ precursor fate by directing N... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:23609534 The S3 cleavage releases the Notch intracellular domain (NICD) from the membrane, and the NICD translocates to the pIIa cell nucleus and interacts with the DNA-binding protein CSL (CBF1/Suppressor of Hairless/Lag1) and the transcriptional coactivator Mastermind to regulate Notch target gene expression |
| GO:0005515 protein binding | IPI PMID:24855951 Compensatory flux changes within an endocytic trafficking ne... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:24855951 ResultsOpposing Temperature Dependencies of Notch Signaling by Different RoutesN signaling can be activated through cell surface interactions with ligand or by ligand-independent trafficking of the full-length receptor to the late endosome and lysosome |
| GO:0005515 protein binding | IPI PMID:25155514 Uninflatable and Notch control the targeting of Sara endosom... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:25155514 Notch binds Uninflatable, and both traffic together through Sara endosomes, which is essential to direct asymmetric endosomes motility and Notch-dependent cell fate assignation |
| GO:0005515 protein binding | IPI PMID:29309414 AKAP200 promotes Notch stability by protecting it from Cbl/l... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:29309414 Through genetic interactions, we demonstrate that AKAP200 interacts positively with Notch in both the eye and the thorax |
| GO:0005515 protein binding | IPI PMID:7671825 Deltex acts as a positive regulator of Notch signaling throu... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:7671825 Experiments involving cell cultures indicate that the Deltex-Notch interaction prevents the cytoplasmic retention of the Suppressor of Hairless protein, which otherwise is sequestered in the cytoplasm via association with the Notch ankyrin repeats and translocates to the nucleus when Notch binds to its ligand Delta |
| GO:0005515 protein binding | IPI PMID:7954795 The suppressor of hairless protein participates in notch rec... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:7954795 In a genetic screen for mutations that attenuate Notch signaling in the developing Drosophila eye, we isolated rare, gain-of-function alleles of Suppressor of Hairless (Su(H)), the fly homolog of the mammalian C promoter-binding factor 1 (CBF1) gene |
| GO:0005515 protein binding | IPI PMID:8162848 Cytosolic interaction between deltex and Notch ankyrin repea... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:8162848 We have demonstrated a direct interaction between these proteins from expression studies conducted in cultured cells, in yeast, and in the imaginal wing disc. deltex binds specifically to the Notch ankyrin repeats, a region that is crucial for Notch signaling and that constitutes the most conserved domain among Notch family members |
| GO:0005515 protein binding | IPI PMID:8749394 Physical interaction between a novel domain of the receptor ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:8749394 In vitro interaction studies, using proteins fused to glutathione-S-transferase, showed that RBP-J kappa and Su(H) bind directly to the RAM23 regions of mouse Notch1 and Drosophila Notch, respectively |
| GO:0005515 protein binding | IPI PMID:9872749 Processing of the notch ligand delta by the metalloprotease ... | REMOVE | Summary: Generic protein binding (IPI) reflecting one of many reported Notch interactions (Delta, Su(H), Deltex, Nedd4/Su(dx), Numb/Sanpodo, Canoe, Akap200 and others). Reason: Protein binding is uninformative. Ligand binding is captured by transmembrane signaling receptor activity, Su(H) binding by transcription coactivator activity and the CSL-Notch-Mastermind complex, and E3 ligase/trafficking-factor interactions describe Notch as a substrate or cargo. Removal does not imply the interaction is false. Supporting Evidence: PMID:9872749 This signaling is triggered by the interaction of the Notch protein with what, so far, have been thought to be transmembrane ligands expressed on adjacent cells |
| GO:0005634 nucleus | IDA PMID:12556495 Signal-induced transcriptional activation by Dif requires th... | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:12556495 When the naturally occurring Drosophila activation domains were tested by a GST pulldown assay, the GST-fused activation domains of Armadillo, Dif, HSF, Notch, and Dorsal coprecipitated with the Mediator complex from Drosophila cell nuclear extracts (Fig. 2A ) PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:8343960 Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. |
| GO:0005634 nucleus | IDA PMID:20482700 Dynamic intracellular distribution of Notch during activatio... | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:20482700 Kinetic analysis revealed that activation of Notch-GFP by ectodomain shedding causes fast and unrestricted nuclear translocation of Notch intracellular domain PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:8343960 Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. |
| GO:0005634 nucleus | IDA PMID:31142544 Regulation of Notch signaling by the chromatin-modeling prot... | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:31142544 In the present study, immunocytochemical analyses demonstrate that Htk and overexpressed Notch-ICD colocalize in the same nuclear compartment PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:8343960 Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:8343960 Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. |
| GO:0005634 nucleus | IMP PMID:8343960 Intrinsic activity of the Lin-12 and Notch intracellular dom... | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:8343960 Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. |
| GO:0005634 nucleus | NAS PMID:21737682 Structural and functional analysis of the repressor complex ... | ACCEPT | Summary: Upon S3 cleavage the Notch intracellular domain translocates to the nucleus. Reason: Nuclear NICD is the signaling-active form that forms the CSL-Notch-Mastermind complex on target enhancers. Supporting Evidence: PMID:21737682 MEFs were transiently transfected with the 4xCBS luciferase reporter, which contains four iterative CSL-binding sites, an activated form of mouse Notch1 (ICN1), and a green fluorescent protein (GFP)βHairless NT construct that was targeted to the nucleus by a NLS sequence PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:8343960 Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. |
| GO:0005654 nucleoplasm | TAS Reactome:R-DME-159111 | ACCEPT | Summary: NICD acts in the nucleoplasm on target chromatin (Reactome). Reason: Consistent with nuclear coactivator function. Supporting Evidence: PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:0005737 cytoplasm | IDA PMID:20482700 Dynamic intracellular distribution of Notch during activatio... | KEEP AS NON CORE | Summary: Notch intracellular domain/fragments detected in the cytoplasm/cytosol. Reason: NICD transits the cytosol en route to the nucleus and Notch is present on cytoplasmic trafficking compartments; correct but not a site of core function. Supporting Evidence: PMID:20482700 Notch signaling mediates intercellular communication required for cell fate specification |
| GO:0005764 lysosome | IDA PMID:20482700 Dynamic intracellular distribution of Notch during activatio... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:20482700 Because the majority of Notch proteins exist as an intracellular pool, information on intracellular trafficking of Notch is essential for understanding its regulation |
| GO:0005768 endosome | IDA PMID:19295516 Directional Delta and Notch trafficking in Sara endosomes du... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:19295516 Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division |
| GO:0005768 endosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. |
| GO:0005769 early endosome | IDA PMID:14627723 Echinoid facilitates Notch pathway signalling during Drosoph... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:14627723 We show that during sense organ precursor specification in Drosophila, the cell adhesion molecule Echinoid colocalises extensively with the Notch ligand, Delta, at the cell membrane and in early endosomes |
| GO:0005770 late endosome | IDA PMID:20482700 Dynamic intracellular distribution of Notch during activatio... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:20482700 Because the majority of Notch proteins exist as an intracellular pool, information on intracellular trafficking of Notch is essential for understanding its regulation |
| GO:0005770 late endosome | IDA PMID:25365996 A fluorescent tagging approach in Drosophila reveals late en... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:25365996 A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo |
| GO:0005771 multivesicular body | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. |
| GO:0005783 endoplasmic reticulum | IMP PMID:27129198 Dual Roles of O-Glucose Glycans Redundant with Monosaccharid... | KEEP AS NON CORE | Summary: Notch transits the secretory pathway where its EGF repeats are O-fucosylated (Ofut1), O-glucosylated (Rumi) and elongated by Fringe. Reason: ER/Golgi localization (lumenal ectodomain) reflects biosynthesis and glycosylation of the receptor, a regulatory step, not the site of signaling. Kept as non-core. Supporting Evidence: PMID:27129198 However, our analyses of double mutants of shams and other genes required for glycan modifications revealed that both the monosaccharide O-glucose and the terminal dixylose of O-glucose-linked saccharides function redundantly with the monosaccharide O-fucose in Notch activation and trafficking |
| GO:0005788 endoplasmic reticulum lumen | TAS Reactome:R-DME-1984022 | KEEP AS NON CORE | Summary: Notch transits the secretory pathway where its EGF repeats are O-fucosylated (Ofut1), O-glucosylated (Rumi) and elongated by Fringe. Reason: ER/Golgi localization (lumenal ectodomain) reflects biosynthesis and glycosylation of the receptor, a regulatory step, not the site of signaling. Kept as non-core. |
| GO:0005788 endoplasmic reticulum lumen | TAS Reactome:R-DME-2032746 | KEEP AS NON CORE | Summary: Notch transits the secretory pathway where its EGF repeats are O-fucosylated (Ofut1), O-glucosylated (Rumi) and elongated by Fringe. Reason: ER/Golgi localization (lumenal ectodomain) reflects biosynthesis and glycosylation of the receptor, a regulatory step, not the site of signaling. Kept as non-core. |
| GO:0005796 Golgi lumen | TAS Reactome:R-DME-1984022 | KEEP AS NON CORE | Summary: Notch transits the secretory pathway where its EGF repeats are O-fucosylated (Ofut1), O-glucosylated (Rumi) and elongated by Fringe. Reason: ER/Golgi localization (lumenal ectodomain) reflects biosynthesis and glycosylation of the receptor, a regulatory step, not the site of signaling. Kept as non-core. |
| GO:0005796 Golgi lumen | TAS Reactome:R-DME-2032746 | KEEP AS NON CORE | Summary: Notch transits the secretory pathway where its EGF repeats are O-fucosylated (Ofut1), O-glucosylated (Rumi) and elongated by Fringe. Reason: ER/Golgi localization (lumenal ectodomain) reflects biosynthesis and glycosylation of the receptor, a regulatory step, not the site of signaling. Kept as non-core. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Notch intracellular domain/fragments detected in the cytoplasm/cytosol. Reason: NICD transits the cytosol en route to the nucleus and Notch is present on cytoplasmic trafficking compartments; correct but not a site of core function. |
| GO:0005829 cytosol | TAS Reactome:R-DME-159111 | KEEP AS NON CORE | Summary: Notch intracellular domain/fragments detected in the cytoplasm/cytosol. Reason: NICD transits the cytosol en route to the nucleus and Notch is present on cytoplasmic trafficking compartments; correct but not a site of core function. |
| GO:0005886 plasma membrane | IDA PMID:25365996 A fluorescent tagging approach in Drosophila reveals late en... | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (IDA). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:25365996 Maturation of Cherry-tagged Notch. (A and Aβ²) Cherry fluorescence of NiCherry (red) was detected at the apical plasma membrane in krz mutant cells (marked by the loss of the GFP marker; clone border indicated in white) but not in wild-type cells PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | IDA PMID:7954795 The suppressor of hairless protein participates in notch rec... | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (IDA). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:7954795 In a genetic screen for mutations that attenuate Notch signaling in the developing Drosophila eye, we isolated rare, gain-of-function alleles of Suppressor of Hairless (Su(H)), the fly homolog of the mammalian C promoter-binding factor 1 (CBF1) gene PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (IEA). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | TAS Reactome:R-DME-2071846 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (TAS). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | TAS Reactome:R-DME-2076706 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (TAS). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | TAS Reactome:R-DME-209226 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (TAS). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-2071858 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (TAS). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0005911 cell-cell junction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Notch localizes near adherens junctions of epithelial cells. Reason: Documented localization in epithelia (apical/junctional region), but not a core feature of the receptor function. |
| GO:0005912 adherens junction | IMP PMID:27129198 Dual Roles of O-Glucose Glycans Redundant with Monosaccharid... | KEEP AS NON CORE | Summary: Notch localizes near adherens junctions of epithelial cells. Reason: Documented localization in epithelia (apical/junctional region), but not a core feature of the receptor function. Supporting Evidence: PMID:27129198 The terminal dixylose of O-glucose-linked saccharides and the monosaccharide O-glucose were required in distinct Notch trafficking processes: Notch transport from the apical plasma membrane to adherens junctions, and Notch export from the endoplasmic reticulum, respectively |
| GO:0006110 regulation of glycolysis | IMP PMID:26887408 Notch stimulates growth by direct regulation of genes involv... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of glycolysis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:26887408 Loss of Notch signalling in Drosophila wing discs as well as in human microvascular cells leads to downregulation of glycolytic genes |
| GO:0007015 actin filament organization | IMP PMID:16049109 Influence of Notch on dorsoventral compartmentalization and ... | KEEP AS NON CORE | Summary: N IMP annotation to 'actin filament organization'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16049109 Activation of the Notch receptor is required for dorsoventral (DV) compartmentalization of the Drosophila wing, but the nature of its requirement has been controversial |
| GO:0007219 Notch signaling pathway | IDA PMID:15611340 The adhesion force of Notch with Delta and the rate of Notch... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IDA). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:15611340 Notch signaling and the various Notch receptors used in this paper. (A) The SuH/Nintra signaling pathway. (B) The structures of Notch receptors used in this paper; relative activities shown on an arbitrary scale PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IDA PMID:17545467 Notch activation stimulates transient and selective binding ... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IDA). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:17545467 Keywords: Notch, chromatin, developmental signaling, transcription factor, CSL proteins, E(spl) complex The Notch signaling pathway plays an important role in a wide diversity of developmental contexts ( Artavanis-Tsakonas et al. 1999 ; Schweisguth 2004 ; Bray 2006 ) PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IDA PMID:29478922 Activation of the Notch Signaling Pathway InΒ Vivo Elicits Ch... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IDA). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:29478922 Introduction Notch is the receptor in a highly conserved cell-cell signaling pathway, whose normal function is essential both during development and throughout adult life (Borggrefe and Oswald, 2009, Bray, 2016, Bray, 2006, Kopan and Ilagan, 2009) PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IEA). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IGI PMID:10790334 Spatially restricted factors cooperate with notch in the reg... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IGI). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:10790334 Activated Notch or a Suppressor of Hairless-VP16 fusion are only sufficient to elicit transcription from the E(spl) enhancers in a subset of locations, indicating a requirement for other factors PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IGI PMID:2123462 deltex, a locus interacting with the neurogenic genes, Notch... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IGI). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:2123462 deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IGI PMID:29195077 Epsin-Dependent Ligand Endocytosis Activates Notch by Force. | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IGI). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:29195077 We demonstrate in vivo that ligands that cannot enter the Epsin pathway nevertheless bind Notch but fail to activate the receptor because they cannot exert sufficient force PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IGI PMID:9570768 Cell proliferation control by Notch signaling in Drosophila ... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IGI). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:9570768 Cell proliferation control by Notch signaling in Drosophila development PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:10903170 The enhancer of split complex of Drosophila includes four No... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:10903170 The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:16145661 Nicastrin controls aspects of photoreceptor neuron specifica... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:16145661 Thus, Notch signaling plays a role, not only in cell fate specification, but also in differentiation of photoreceptor neurons PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:1657403 Specific EGF repeats of Notch mediate interactions with Delt... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:1657403 Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:16643882 Notch pathway repression by vestigial is required to promote... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:16643882 Moreover, close examination of the cellular location of several of the main actors of the N pathway (Notch, Delta, neuralized, Serrate, Mind bomb1 and fringe) during dorsal longitudinal muscle development enabled us to find that Notch receptor can play multiple roles in adult myogenesis PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:2338245 The Notch locus and the genetic circuitry involved in early ... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:2338245 The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:25329825 The bHLH-PAS transcription factor dysfusion regulates tarsal... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:25329825 Development of both proximal and distal joints requires Notch activity; however, it is still unknown how this pathway can control the development of such homologous although distinct structures PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:28960177 Ubiquitylation-independent activation of Notch signalling by... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:28960177 IntroductionSignalling through the Notch signalling pathway is required in many developmental processes of probably all metazoans (Bray, 2006; FiΓΊza and Arias, 2007) PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:35264151 Ubiquitylation is required for the incorporation of the Notc... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:35264151 Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:41556123 Kuzbanian expression levels dictate Notch signaling outcomes... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:41556123 Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | IMP PMID:8600026 Delta is a ventral to dorsal signal complementary to Serrate... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (IMP). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:8600026 Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007219 Notch signaling pathway | NAS PMID:21737682 Structural and functional analysis of the repressor complex ... | ACCEPT | Summary: N encodes the Drosophila Notch receptor, the defining component of the Notch signaling pathway (NAS). Reason: Notch binds the DSL ligands Delta and Serrate through EGF repeats 11-12, undergoes regulated proteolysis, and its intracellular domain enters the nucleus to form an activator complex with Su(H) and Mastermind at E(spl) and other targets. Participation in the Notch signaling pathway is the core biological process of this gene. Supporting Evidence: PMID:21737682 Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster PMID:7954795 In cultured Drosophila cells, the Su(H) protein is sequestered in the cytoplasm when coexpressed with Notch protein and is translocated to the nucleus when Notch binds to its ligand Delta. PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0007293 germarium-derived egg chamber formation | IMP PMID:11493544 fringe and Notch specify polar cell fate during Drosophila o... | KEEP AS NON CORE | Summary: N IMP annotation to 'germarium-derived egg chamber formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11493544 Clones of cells mutant for Notch also lack polar cells and the requirement for Notch in follicle formation appears to map to the polar cells |
| GO:0007297 follicle cell of egg chamber migration | IMP PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anter... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis |
| GO:0007298 border follicle cell migration | IMP PMID:16014514 Function of the ETS transcription factor Yan in border cell ... | KEEP AS NON CORE | Summary: N IMP annotation to 'border follicle cell migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16014514 Yan expression is dependent on inputs from the JAK/STAT, Notch and Receptor Tyrosine Kinase pathways in border cells |
| GO:0007298 border follicle cell migration | IMP PMID:17010965 Spatially localized Kuzbanian required for specific activati... | KEEP AS NON CORE | Summary: N IMP annotation to 'border follicle cell migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17010965 Spatially localized Kuzbanian required for specific activation of Notch during border cell migration |
| GO:0007346 regulation of mitotic cell cycle | TAS PMID:14616073 Regulation of cell cycles in Drosophila development: intrins... | KEEP AS NON CORE | Summary: N TAS annotation to 'regulation of mitotic cell cycle'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007391 dorsal closure | TAS PMID:12147138 Signaling pathways directing the movement and fusion of epit... | KEEP AS NON CORE | Summary: N TAS annotation to 'dorsal closure'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12147138 At the center of this network is a Jun N-terminal kinase cascade acting at the leading edge of the migrating epidermis that triggers signaling by the TGF-beta superfamily member Decapentaplegic and which interacts with the Wingless pathway |
| GO:0007400 neuroblast fate determination | IDA PMID:19782677 On the roles of Notch, Delta, kuzbanian, and inscuteable dur... | KEEP AS NON CORE | Summary: N IDA annotation to 'neuroblast fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19782677 In this context, Notch is required to be active in one sibling and inactive in the other |
| GO:0007400 neuroblast fate determination | IGI PMID:28242614 Prevention of medulla neuron dedifferentiation by Nerfin-1 r... | KEEP AS NON CORE | Summary: N IGI annotation to 'neuroblast fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28242614 Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion |
| GO:0007400 neuroblast fate determination | IMP PMID:28306050 A late role for a subset of neurogenic genes to limit sensor... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28306050 In order to find out whether the neurogenic genes only act at this intial step of neurogenesis, we studied the replication pattern of the sensory organ precursor cells by monitoring BrdU incorporation in embryos mutant for Notch (N), Delta (Dl), mastermind (mam), almondex (amx), neuralized (neu), big brain (bib) and the Enhancer of split-Complex (E(spl)-C) |
| GO:0007403 glial cell fate determination | IMP PMID:11262238 Notch signaling represses the glial fate in fly PNS. | KEEP AS NON CORE | Summary: N IMP annotation to 'glial cell fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11262238 Notch acts as a genetic switch between neuronal and glial fates by negatively regulating glial cell deficient/glial cells missing, the gene required in the glial precursor to induce gliogenesis |
| GO:0007403 glial cell fate determination | IMP PMID:11262244 A requirement for Notch in the genesis of a subset of glial ... | KEEP AS NON CORE | Summary: N IMP annotation to 'glial cell fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11262244 A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions |
| GO:0007403 glial cell fate determination | IMP PMID:11973271 Context-dependent utilization of Notch activity in Drosophil... | KEEP AS NON CORE | Summary: N IMP annotation to 'glial cell fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11973271 A recent report showed that in the adult bristle lineage, gcm expression is negatively regulated by Notch signaling ( Van De Bor, V. and Giangrande, A. (2001) |
| GO:0007405 neuroblast proliferation | IMP PMID:18342578 The tumor suppressors Brat and Numb regulate transit-amplify... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:18342578 We propose that these events are the source of the overgrowing neuroblasts characteristic of brat mutant brains.Notch Signaling Regulates Secondary Neuroblasts in PAN LineagesWe have shown that loss of Brat causes defective differentiation in transit-amplifying secondary neuroblasts and that this leads to overgrowth |
| GO:0007411 axon guidance | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'axon guidance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007411 axon guidance | IMP PMID:12781136 Notch steers Drosophila ISNb motor axons by regulating the A... | KEEP AS NON CORE | Summary: N IMP annotation to 'axon guidance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12781136 Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway |
| GO:0007422 peripheral nervous system development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'peripheral nervous system development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007422 peripheral nervous system development | IMP PMID:11262238 Notch signaling represses the glial fate in fly PNS. | KEEP AS NON CORE | Summary: N IMP annotation to 'peripheral nervous system development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11262238 Notch acts as a genetic switch between neuronal and glial fates by negatively regulating glial cell deficient/glial cells missing, the gene required in the glial precursor to induce gliogenesis |
| GO:0007423 sensory organ development | IMP PMID:11719214 Novel Notch alleles reveal a Deltex-dependent pathway repres... | KEEP AS NON CORE | Summary: N IMP annotation to 'sensory organ development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11719214 We show that the loss of sensory organs associated with this phenotype results from a constitutive activation of a Deltex-dependent Notch-signaling event |
| GO:0007424 open tracheal system development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'open tracheal system development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007440 foregut morphogenesis | IMP PMID:14975725 Cooperation of JAK/STAT and Notch signaling in the Drosophil... | KEEP AS NON CORE | Summary: N IMP annotation to 'foregut morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14975725 We demonstrate by analyzing gene expression mediated by a model Notch response element and by studying the expression of the Notch target gene short stop, which encodes a cytoskeletal crosslinker protein, that JAK/STAT signaling is required for the activation of Notch-dependent gene expression in the foregut |
| GO:0007455 eye-antennal disc morphogenesis | IMP PMID:10681430 Notch signaling and the determination of appendage identity. | KEEP AS NON CORE | Summary: N IMP annotation to 'eye-antennal disc morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10681430 Similar results also were obtained with ey R , the other hypomorphic allele (data not shown), but no ectopic antennae were found in ey-GAL4 UAS-N act ey + flies (Fig. 1 c ), indicating that Notch signaling induces antenna formation in a loss-of-function ey mutant background |
| GO:0007455 eye-antennal disc morphogenesis | IMP PMID:28708823 Notch-dependent epithelial fold determines boundary formatio... | KEEP AS NON CORE | Summary: N IMP annotation to 'eye-antennal disc morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28708823 By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold |
| GO:0007474 imaginal disc-derived wing vein specification | IMP PMID:15452147 Regulation of Notch signaling by Drosophila heparan sulfate ... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing vein specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15452147 We also show that levels of Notch protein on the cell surface were markedly decreased by loss of Hs3st-B. These findings suggest that Hs3st-B is involved in Notch signaling by affecting stability or intracellular trafficking of Notch protein |
| GO:0007476 imaginal disc-derived wing morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'imaginal disc-derived wing morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007476 imaginal disc-derived wing morphogenesis | IMP PMID:10681430 Notch signaling and the determination of appendage identity. | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10681430 Similar results also were obtained with ey R , the other hypomorphic allele (data not shown), but no ectopic antennae were found in ey-GAL4 UAS-N act ey + flies (Fig. 1 c ), indicating that Notch signaling induces antenna formation in a loss-of-function ey mutant background |
| GO:0007476 imaginal disc-derived wing morphogenesis | IMP PMID:12782270 Vein-positioning in the Drosophila wing in response to Hh; n... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12782270 Vein-positioning in the Drosophila wing in response to Hh; new roles of Notch signaling |
| GO:0007476 imaginal disc-derived wing morphogenesis | IMP PMID:14536058 Phospholipid membrane composition affects EGF receptor and N... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14536058 Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development |
| GO:0007476 imaginal disc-derived wing morphogenesis | IMP PMID:18987026 Notch signalling coordinates tissue growth and wing fate spe... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:18987026 We present evidence that growth of the wing primordium mediated by the activity of Notch is required for wing fate specification |
| GO:0007478 leg disc morphogenesis | TAS PMID:10625531 Subdividing cell populations in the developing limbs of Dros... | KEEP AS NON CORE | Summary: N TAS annotation to 'leg disc morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007480 imaginal disc-derived leg morphogenesis | IMP PMID:10357942 Composite signalling from Serrate and Delta establishes leg ... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10357942 Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch |
| GO:0007480 imaginal disc-derived leg morphogenesis | IMP PMID:10681430 Notch signaling and the determination of appendage identity. | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10681430 Similar results also were obtained with ey R , the other hypomorphic allele (data not shown), but no ectopic antennae were found in ey-GAL4 UAS-N act ey + flies (Fig. 1 c ), indicating that Notch signaling induces antenna formation in a loss-of-function ey mutant background |
| GO:0007480 imaginal disc-derived leg morphogenesis | IMP PMID:9806911 Notch signalling mediates segmentation of the Drosophila leg... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:9806911 We find that Notch is locally activated in distal cells of each segment, as demonstrated by the restricted expression of the Enhancer of split mbeta gene, and is required for the formation of normal joints |
| GO:0007498 mesoderm development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'mesoderm development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007498 mesoderm development | IMP PMID:1913825 A role for the Drosophila neurogenic genes in mesoderm diffe... | KEEP AS NON CORE | Summary: N IMP annotation to 'mesoderm development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:1913825 Embryonic cells that express the muscle-specific gene nautilus are overproduced in each of seven neurogenic mutants (Notch, Delta, Enhancer of split, big brain, mastermind, neuralized, and almondex), at the apparent expense of neighboring, nonexpressing mesodermal cells |
| GO:0007521 muscle cell fate determination | IMP PMID:12756185 Myogenic cells fates are antagonized by Notch only in asymme... | KEEP AS NON CORE | Summary: N IMP annotation to 'muscle cell fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12756185 These progenitors adopt a pericardial cell fate, however, when cell division is blocked in numb mutants or in embryos with constitutive Notch activity |
| GO:0007548 sex differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'sex differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0007615 anesthesia-resistant memory | IMP NOT PMID:15220476 Notch signaling in Drosophila long-term memory formation. | KEEP AS NON CORE | Summary: N IMP annotation to 'anesthesia-resistant memory'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15220476 Notch signaling in Drosophila long-term memory formation |
| GO:0007616 long-term memory | IGI PMID:19104051 The Drosophila cell adhesion molecule klingon is required fo... | KEEP AS NON CORE | Summary: N IGI annotation to 'long-term memory'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19104051 Although defects in Notch have been implicated in memory loss because of Alzheimer's disease, downstream signaling linking Notch to memory have not been determined |
| GO:0007616 long-term memory | IMP PMID:15220476 Notch signaling in Drosophila long-term memory formation. | KEEP AS NON CORE | Summary: N IMP annotation to 'long-term memory'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15220476 Notch signaling in Drosophila long-term memory formation |
| GO:0007616 long-term memory | IMP PMID:23904617 Notch-inducible hyperphosphorylated CREB and its ultradian o... | KEEP AS NON CORE | Summary: N IMP annotation to 'long-term memory'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:23904617 Because Notch is a cell surface receptor that is known to regulate intracellular signaling molecules, we examined the most direct hypothesis that Notch regulates CREB. N ts1 is a temperature-sensitive loss-of-function (LOF) Notch allele, which has been used previously to show Notch requirement for LTM formation ( Presente et al., 2004 ) |
| GO:0008045 motor neuron axon guidance | IMP PMID:21246649 Noncanonical Notch function in motor axon guidance is mediat... | KEEP AS NON CORE | Summary: N IMP annotation to 'motor neuron axon guidance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21246649 This result suggests that among Rho GTPases, Rac is preferentially required in the genetic pathway of Notch signaling for patterning ISNb motor axons.To test this hypothesis further, we employed dominant negative or constitutively active forms of Rac |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'positive regulation of cell population proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:16039641 Notch signaling controls proliferation through cell-autonomo... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of cell population proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16039641 Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye |
| GO:0008340 determination of adult lifespan | IMP PMID:11711879 Requirement of Notch in adulthood for neurological function ... | KEEP AS NON CORE | Summary: N IMP annotation to 'determination of adult lifespan'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11711879 A progressive neurological syndrome with loss of flight and shortened lifespan was observed in adults with compromised Notch function |
| GO:0008347 glial cell migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'glial cell migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0008347 glial cell migration | IMP PMID:17157832 Notch and Numb are required for normal migration of peripher... | KEEP AS NON CORE | Summary: N IMP annotation to 'glial cell migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17157832 Since the glial migration phenotypes of Notch and numb mutants resemble each other, our data support a model where the precise temporal and quantitative regulation of Numb and Notch activity is not only required during fate decisions but also later during glial differentiation and migration |
| GO:0008356 asymmetric cell division | TAS PMID:12593977 Genetic control of Drosophila nerve cord development. | KEEP AS NON CORE | Summary: N TAS annotation to 'asymmetric cell division'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0008356 asymmetric cell division | TAS PMID:15018932 Asymmetric localization and function of cell-fate determinan... | KEEP AS NON CORE | Summary: N TAS annotation to 'asymmetric cell division'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0008407 chaeta morphogenesis | IMP PMID:16168983 Evidence that nervy, the Drosophila homolog of ETO/MTG8, pro... | KEEP AS NON CORE | Summary: N IMP annotation to 'chaeta morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16168983 Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:12897132 Regulation of Notch signaling by a novel mechanism involving... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12897132 N 60g11 /+ flies show gain of lateral inhibition signaling (SuH- and N intra -dependent or Deltex-dependent N signaling) at 18Β°C (manifest as loss of bristles) and loss at room temperature or higher (manifest as notched wings); wing development at 18Β°C and bristle development at higher temperatures are normal ( 6 , 28 , 34 ) |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:15452147 Regulation of Notch signaling by Drosophila heparan sulfate ... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15452147 We also show that levels of Notch protein on the cell surface were markedly decreased by loss of Hs3st-B. These findings suggest that Hs3st-B is involved in Notch signaling by affecting stability or intracellular trafficking of Notch protein |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:1657403 Specific EGF repeats of Notch mediate interactions with Delt... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:1657403 Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:19027066 Notch down-regulation by endocytosis is essential for pigmen... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19027066 An increase in Notch signaling is also observed in Drosophila wings in response to the mutant clathrin, suggesting that Notch levels are controlled by clathrin-dependent endocytosis |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:8600026 Delta is a ventral to dorsal signal complementary to Serrate... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:8600026 The effect is mediated by Notch, because loss of Notch activity suppresses Delta-induced ectopic wing outgrowth |
| GO:0008587 imaginal disc-derived wing margin morphogenesis | IMP PMID:9570768 Cell proliferation control by Notch signaling in Drosophila ... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived wing margin morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:9570768 Cell proliferation control by Notch signaling in Drosophila development |
| GO:0009608 response to symbiont | IMP PMID:12445385 Notch signaling controls lineage specification during Drosop... | KEEP AS NON CORE | Summary: N IMP annotation to 'response to symbiont'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12445385 Notch signaling controls lineage specification during Drosophila larval hematopoiesis |
| GO:0009792 embryo development ending in birth or egg hatching | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'embryo development ending in birth or egg hatching'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0009950 dorsal/ventral axis specification | IMP PMID:23861806 Notch and PKC are involved in formation of the lateral regio... | KEEP AS NON CORE | Summary: N IMP annotation to 'dorsal/ventral axis specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:23861806 The extent of the ventral region appeared to be unaffected and manifested loss of neuronal cells, which is consistent with the gain of canonical Notch signaling in this region |
| GO:0009952 anterior/posterior pattern specification | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'anterior/posterior pattern specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0009953 dorsal/ventral pattern formation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'dorsal/ventral pattern formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0009986 cell surface | IDA PMID:14627723 Echinoid facilitates Notch pathway signalling during Drosoph... | ACCEPT | Summary: Notch is a cell-surface transmembrane receptor. Reason: Consistent with the receptor function; accepted (plasma membrane is the more informative term). Supporting Evidence: PMID:14627723 We show that during sense organ precursor specification in Drosophila, the cell adhesion molecule Echinoid colocalises extensively with the Notch ligand, Delta, at the cell membrane and in early endosomes |
| GO:0009986 cell surface | IDA PMID:21771811 Multiple O-glucosylation sites on Notch function as a buffer... | ACCEPT | Summary: Notch is a cell-surface transmembrane receptor. Reason: Consistent with the receptor function; accepted (plasma membrane is the more informative term). Supporting Evidence: PMID:21771811 Drosophila Notch protein and its ligands, Delta and Serrate, are type I transmembrane proteins with multiple epidermal growth factor-like (EGF) repeats in their extracellular domain |
| GO:0009986 cell surface | IEA GO_REF:0000117 | ACCEPT | Summary: Notch is a cell-surface transmembrane receptor. Reason: Consistent with the receptor function; accepted (plasma membrane is the more informative term). |
| GO:0010001 glial cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'glial cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0010001 glial cell differentiation | IMP PMID:17157832 Notch and Numb are required for normal migration of peripher... | KEEP AS NON CORE | Summary: N IMP annotation to 'glial cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17157832 Since the glial migration phenotypes of Notch and numb mutants resemble each other, our data support a model where the precise temporal and quantitative regulation of Numb and Notch activity is not only required during fate decisions but also later during glial differentiation and migration |
| GO:0010160 formation of animal organ boundary | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'formation of animal organ boundary'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0010628 positive regulation of gene expression | IDA PMID:29629869 A population of adult satellite-like cells in Drosophila is ... | KEEP AS NON CORE | Summary: Notch activity positively regulates expression of specific target genes. Reason: Correct but generic; the mechanistic role is captured by positive regulation of RNA polymerase II transcription via the CSL complex. Kept as non-core. Supporting Evidence: PMID:29629869 Thus, Zfh1-short retains the capacity to block Mef2 induced muscle differentiation (Figure 7βfigure supplement 1).zfh1-short isoform transcription requires Notch activity in adult pMPsExpression of zfh1-short (zfh1-RA) is specifically retained in adult MPs (Figure 7E) where it may be critical for maintaining their progenitor status |
| GO:0010628 positive regulation of gene expression | IMP PMID:22357926 bHLH-O proteins are crucial for Drosophila neuroblast self-r... | KEEP AS NON CORE | Summary: Notch activity positively regulates expression of specific target genes. Reason: Correct but generic; the mechanistic role is captured by positive regulation of RNA polymerase II transcription via the CSL complex. Kept as non-core. Supporting Evidence: PMID:22357926 In fact E(spl) overexpression can partly mimic Notch-induced overproliferation |
| GO:0010628 positive regulation of gene expression | IMP PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: Notch activity positively regulates expression of specific target genes. Reason: Correct but generic; the mechanistic role is captured by positive regulation of RNA polymerase II transcription via the CSL complex. Kept as non-core. Supporting Evidence: PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff |
| GO:0010629 negative regulation of gene expression | IMP PMID:16828735 Border of Notch activity establishes a boundary between the ... | KEEP AS NON CORE | Summary: Notch signaling represses expression of particular genes in specific contexts. Reason: Repression downstream of Notch is largely indirect (e.g. via E(spl) bHLH repressors); plausible, context-dependent and non-core. Supporting Evidence: PMID:16828735 The Notch expression pattern mimics the boundary; Notch levels are high in Rhomboid cells and low in Broad cells |
| GO:0010629 negative regulation of gene expression | IMP PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: Notch signaling represses expression of particular genes in specific contexts. Reason: Repression downstream of Notch is largely indirect (e.g. via E(spl) bHLH repressors); plausible, context-dependent and non-core. Supporting Evidence: PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff |
| GO:0010631 epithelial cell migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'epithelial cell migration'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0012505 endomembrane system | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. |
| GO:0014018 neuroblast fate specification | IMP PMID:8343960 Intrinsic activity of the Lin-12 and Notch intracellular dom... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast fate specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:8343960 The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling |
| GO:0014019 neuroblast development | IMP PMID:18342578 The tumor suppressors Brat and Numb regulate transit-amplify... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:18342578 We propose that these events are the source of the overgrowing neuroblasts characteristic of brat mutant brains.Notch Signaling Regulates Secondary Neuroblasts in PAN LineagesWe have shown that loss of Brat causes defective differentiation in transit-amplifying secondary neuroblasts and that this leads to overgrowth |
| GO:0014019 neuroblast development | IMP PMID:19762424 Lineage-specific cell death in postembryonic brain developme... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19762424 Furthermore, we provide evidence that Notch signaling is involved in the regulation of en expression |
| GO:0014019 neuroblast development | IMP PMID:23056424 The bHLH repressor Deadpan regulates the self-renewal and sp... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuroblast development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:23056424 Second, we examined whether lowering Notch expression enhances the loss of type II NBs in dpn7 heterozygous larval brains. dpn7 heterozygous mutant larvae contained a slightly reduced number of type II NBs (about 6 per brain lobe) (Fig. 8C), thus providing a sensitized genetic background |
| GO:0016020 membrane | IDA PMID:15611340 The adhesion force of Notch with Delta and the rate of Notch... | ACCEPT | Summary: Notch is a cell-surface transmembrane receptor. Reason: Consistent with the receptor function; accepted (plasma membrane is the more informative term). Supporting Evidence: PMID:15611340 The Notch intracellular domain (Nintra) is released from the plasma membrane, translocated to the nucleus, and in association with the transcription factor Suppressor of Hairless (SuH) activates transcription of target genes such as the Enhancer of split Complex (E(spl)C) genes (see Fig. 1 A) |
| GO:0016020 membrane | IEA GO_REF:0000002 | ACCEPT | Summary: Notch is a cell-surface transmembrane receptor. Reason: Consistent with the receptor function; accepted (plasma membrane is the more informative term). |
| GO:0016318 ommatidial rotation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'ommatidial rotation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0016318 ommatidial rotation | IGI PMID:36476875 Notch-dependent Abl signaling regulates cell motility during... | KEEP AS NON CORE | Summary: N IGI annotation to 'ommatidial rotation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:36476875 Loss-of-function (LOF) and gain-of-function (GOF) genotypes of dAbl consistently cause opposite effects on the OR process. dAbl becomes apically localized in photoreceptors R8, R2/R5 and importantly R4, but not in R3, during OR. Apical junctional localization in R4 requires Notch signaling |
| GO:0016324 apical plasma membrane | EXP PMID:9012507 The neurogenic genes egghead and brainiac define a novel sig... | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (EXP). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:9012507 By comparing the function of germline egh and brn to N during oogenesis, we have obtained direct evidence for the involvement of Notch in maintenance of the follicle cell epithelium, and the specificity of brn and egh in epithelial development during oogenesis PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0016324 apical plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (IEA). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0016324 apical plasma membrane | IMP PMID:27129198 Dual Roles of O-Glucose Glycans Redundant with Monosaccharid... | ACCEPT | Summary: Full-length Notch is a type I transmembrane protein at the plasma membrane, enriched apically in epithelia (IMP). Reason: Plasma membrane (apical and lateral) is where Notch encounters ligands on adjacent cells; well supported by UniProt-cited experimental localization. Supporting Evidence: PMID:27129198 The terminal dixylose of O-glucose-linked saccharides and the monosaccharide O-glucose were required in distinct Notch trafficking processes: Notch transport from the apical plasma membrane to adherens junctions, and Notch export from the endoplasmic reticulum, respectively PMID:15611340 Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. |
| GO:0016328 lateral plasma membrane | EXP PMID:9012507 The neurogenic genes egghead and brainiac define a novel sig... | KEEP AS NON CORE | Summary: Notch is detected at lateral membranes of epithelial cells, to a lesser extent than apically. Reason: Correct subcellular localization; plasma membrane/apical plasma membrane are the principal sites. Non-core refinement. Supporting Evidence: PMID:9012507 By comparing the function of germline egh and brn to N during oogenesis, we have obtained direct evidence for the involvement of Notch in maintenance of the follicle cell epithelium, and the specificity of brn and egh in epithelial development during oogenesis |
| GO:0016328 lateral plasma membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Notch is detected at lateral membranes of epithelial cells, to a lesser extent than apically. Reason: Correct subcellular localization; plasma membrane/apical plasma membrane are the principal sites. Non-core refinement. |
| GO:0016330 second mitotic wave involved in compound eye morphogenesis | IMP PMID:23970418 A Serrate-Notch-Canoe complex mediates essential interaction... | KEEP AS NON CORE | Summary: N IMP annotation to 'second mitotic wave involved in compound eye morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:23970418 Ser is tissue-autonomously required in the glia where it activates Notch to regulate its proliferation, and non-autonomously in the neuroepithelium where Ser induces Notch signaling to avoid the premature activation of the EGFR-Ras pathway and hence of L'sc |
| GO:0016348 imaginal disc-derived leg joint morphogenesis | IMP PMID:21527259 Tarsal-less peptides control Notch signalling through the Sh... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg joint morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21527259 Similarly, tal-lacZ expression is lost from the Nts mutant tarsal joints (Fig. 3B-Bβ²) indicating that N signalling is required for tal expression |
| GO:0016348 imaginal disc-derived leg joint morphogenesis | IMP PMID:25329825 The bHLH-PAS transcription factor dysfusion regulates tarsal... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg joint morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25329825 Next, we tested whether dys is required for the expression of two Notch targets, bib and E(spl)mΞ². When Dys function is reduced or eliminated using dys-RNAi or the dys2/dys3 allelic combination, respectively, we observed a strong downregulation of bib-lacZ expression in the tarsal segments, while E(spl)mΞ²-CD2 is only slightly downregulated or remains unaffected (Figure 3Cβ3F.) |
| GO:0016360 sensory organ precursor cell fate determination | IMP PMID:25155514 Uninflatable and Notch control the targeting of Sara endosom... | KEEP AS NON CORE | Summary: N IMP annotation to 'sensory organ precursor cell fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25155514 Our data uncover a part of the core machinery required for the asymmetric motility of a vesicular structure that is essential for the directed dispatch of Notch signaling molecules during asymmetric mitosis |
| GO:0019899 enzyme binding | IEA GO_REF:0000117 | TOO GENERAL | Summary: Generic electronic (ARBA) binding annotation. Reason: The term is uninformative about Notch function; the relevant interactions (with Su(H), ligands, E3 ligases) are captured by more specific receptor and coactivator terms. Removal does not imply the underlying interactions are false. TOO_GENERAL rather than REMOVE: histone acetyltransferase binding, kept in this review, entails this term, so the claim is true but less informative. |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000117 | TOO GENERAL | Summary: Generic electronic (ARBA) binding annotation. Reason: The term is uninformative about Notch function; the relevant interactions (with Su(H), ligands, E3 ligases) are captured by more specific receptor and coactivator terms. Removal does not imply the underlying interactions are false. TOO_GENERAL rather than REMOVE: WW domain binding, kept in this review, entails this term, so the claim is true but less informative. |
| GO:0022407 regulation of cell-cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'regulation of cell-cell adhesion'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0022416 chaeta development | IMP PMID:19415625 On the mechanism underlying the divergent retinal and bristl... | KEEP AS NON CORE | Summary: N IMP annotation to 'chaeta development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19415625 R8/SOP selection involves inhibitory Notch (N) signaling between the future R8/SOP and its immediate neighbors in a PNC (reviewed in (Artavanis-Tsakonas et al., 1999; Bray, 2006; Mumm and Kopan, 2000)) |
| GO:0030097 hemopoiesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'hemopoiesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0030139 endocytic vesicle | IDA PMID:19668359 Ligand-independent traffic of Notch buffers activated Armadi... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:19668359 Ligand-Independent Traffic of Notch Modulates the Activity of ArmadilloThe pattern and distribution of the CeN protein in the epithelial cells suggests that it is actively trafficking, as it is localized to the apical membrane of cells and to more basal puncta, reminiscent of vesicles, in a pattern that overlaps with that of the endogenous Notch (Figures 4A and 6A) |
| GO:0030154 cell differentiation | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: N IEA annotation to 'cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0030154 cell differentiation | IMP PMID:29276156 A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem ... | KEEP AS NON CORE | Summary: N IMP annotation to 'cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:29276156 A negative role for phyl in Notch signaling has been observed in developing eye imaginal discs, in which phyl is required for endocytic degradation of activated Notch (Nagaraj and Banerjee, 2009) |
| GO:0030707 follicle cell of egg chamber development | IMP PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anter... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis |
| GO:0030707 follicle cell of egg chamber development | IMP PMID:26205122 A large-scale in vivo RNAi screen to identify genes involved... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:26205122 Notch signaling plays a central role in regulating follicle-cell differentiation and cell-cycle switches; its activation is essential for the mitotic cycle/endocycle (M/E) switch |
| GO:0030707 follicle cell of egg chamber development | IMP PMID:29093440 Quantitative microscopy of the Drosophila ovary shows multip... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:29093440 The Notch receptor modifier fringe (fng) mutant44 showed a similar phenotype as loss of Notch (Fig. 7f) |
| GO:0030713 follicle cell of egg chamber stalk formation | IMP PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber stalk formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila |
| GO:0030713 follicle cell of egg chamber stalk formation | IMP PMID:9012507 The neurogenic genes egghead and brainiac define a novel sig... | KEEP AS NON CORE | Summary: N IMP annotation to 'follicle cell of egg chamber stalk formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:9012507 By comparing the function of germline egh and brn to N during oogenesis, we have obtained direct evidence for the involvement of Notch in maintenance of the follicle cell epithelium, and the specificity of brn and egh in epithelial development during oogenesis |
| GO:0030718 germ-line stem cell population maintenance | IMP PMID:17287246 Notch signaling controls germline stem cell niche formation ... | KEEP AS NON CORE | Summary: N IMP annotation to 'germ-line stem cell population maintenance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17287246 Notch signaling controls germline stem cell niche formation in the Drosophila ovary |
| GO:0030720 oocyte localization involved in germarium-derived egg chamber formation | IMP PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior... | KEEP AS NON CORE | Summary: N IMP annotation to 'oocyte localization involved in germarium-derived egg chamber formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila |
| GO:0030855 epithelial cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'epithelial cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0031410 cytoplasmic vesicle | IDA PMID:16137928 Sec15, a component of the exocyst, promotes notch signaling ... | KEEP AS NON CORE | Summary: Notch is trafficked through the endocytic pathway (early/Sara endosomes, late endosomes, multivesicular bodies, lysosomes). Reason: Endocytic trafficking regulates Notch availability, ligand-independent activation and lysosomal degradation (ESCRT- and E3 ligase-dependent). Localization is well documented but reflects regulation/turnover of the receptor rather than its core signaling function; kept as non-core. Supporting Evidence: PMID:16137928 In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15, which encodes a component of the exocyst, an evolutionarily conserved complex implicated in intracellular vesicle transport. sec15(-) sensory organs contain extra neurons at the expense of support cells, a phenotype consistent with loss of Notch signaling |
| GO:0032991 protein-containing complex | IPI PMID:17535912 Conformational variability of the intracellular domain of Dr... | MODIFY | Summary: IPI annotation to the generic protein-containing complex term for Notch ANK/ICD complexes with Su(H). Reason: The relevant complex is the CSL-Notch-Mastermind transcription factor complex, which should be used instead of the uninformative root term. Proposed replacements: CSL-Notch-Mastermind transcription factor complex Supporting Evidence: PMID:17535912 Recent x-ray diffraction studies showed that Su(H) does not self-associate in the presence of NICD and that it forms a 1:1 molar complex with NICD through the RAM-ankryin repeat region of Notch ( 9 , 10 ) |
| GO:0035035 histone acetyltransferase binding | IPI PMID:31142544 Regulation of Notch signaling by the chromatin-modeling prot... | KEEP AS NON CORE | Summary: Physical interaction of Notch with the chromatin protein Hat-trick. Reason: Reported interaction relevant to Notch target-gene regulation; it is a specific interaction but a modulatory, non-core aspect of NICD function. Supporting Evidence: PMID:31142544 Using a yeast two-hybrid screen, we identiο¬ed the Drosophila DNA-binding protein Hat-trick (Htk) to be an interacting partner of Notch-intracellular domain (Notch-ICD); their physical interaction was further validated by co-immunoprecipitation experiments. htk genetically interacts with Notch pathway components in trans-heterozygous combinations |
| GO:0035153 epithelial cell type specification, open tracheal system | IMP PMID:16760977 Social interactions among epithelial cells during tracheal b... | KEEP AS NON CORE | Summary: N IMP annotation to 'epithelial cell type specification, open tracheal system'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16760977 Competition appears to involve Notch-mediated lateral inhibition that prevents extra cells from assuming the lead |
| GO:0035162 embryonic hemopoiesis | IMP PMID:12569125 A Serrate-expressing signaling center controls Drosophila he... | KEEP AS NON CORE | Summary: N IMP annotation to 'embryonic hemopoiesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12569125 We also find that a signaling center expressing the ligand Serrate is important for differentiation and proliferation of larval hemocytes in Drosophila . Results and Discussion Notch and Su(H) are required for hemocyte proliferation and development Morphological and molecular differentiation of hemocytes can be monitored in the larval lymph gland ( Shrestha and Gateff 1982 ) |
| GO:0035167 larval lymph gland hemopoiesis | IMP PMID:12569125 A Serrate-expressing signaling center controls Drosophila he... | KEEP AS NON CORE | Summary: N IMP annotation to 'larval lymph gland hemopoiesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12569125 We also find that a signaling center expressing the ligand Serrate is important for differentiation and proliferation of larval hemocytes in Drosophila . Results and Discussion Notch and Su(H) are required for hemocyte proliferation and development Morphological and molecular differentiation of hemocytes can be monitored in the larval lymph gland ( Shrestha and Gateff 1982 ) |
| GO:0035171 lamellocyte differentiation | IMP PMID:12445385 Notch signaling controls lineage specification during Drosop... | KEEP AS NON CORE | Summary: N IMP annotation to 'lamellocyte differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12445385 Notch signaling controls lineage specification during Drosophila larval hematopoiesis |
| GO:0035172 hemocyte proliferation | IMP PMID:12569125 A Serrate-expressing signaling center controls Drosophila he... | KEEP AS NON CORE | Summary: N IMP annotation to 'hemocyte proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12569125 We also find that a signaling center expressing the ligand Serrate is important for differentiation and proliferation of larval hemocytes in Drosophila . Results and Discussion Notch and Su(H) are required for hemocyte proliferation and development Morphological and molecular differentiation of hemocytes can be monitored in the larval lymph gland ( Shrestha and Gateff 1982 ) |
| GO:0035204 negative regulation of lamellocyte differentiation | IMP PMID:24318532 An unexpected link between notch signaling and ROS in restri... | KEEP AS NON CORE | Summary: N IMP annotation to 'negative regulation of lamellocyte differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:24318532 Here we address the role of Notch (N) signaling in lamellocyte differentiation in response to wasp infection |
| GO:0035214 eye-antennal disc development | IMP PMID:18639538 Temporal switching of regulation and function of eye gone (e... | KEEP AS NON CORE | Summary: N IMP annotation to 'eye-antennal disc development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:18639538 We found that Notch signaling is required and sufficient for eyg expression and this activity is restricted only to the L2 stage |
| GO:0035222 wing disc pattern formation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'wing disc pattern formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0035222 wing disc pattern formation | IMP PMID:19701455 In vivo analysis of the Notch receptor S1 cleavage. | KEEP AS NON CORE | Summary: N IMP annotation to 'wing disc pattern formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19701455 We also examined the ability of the mutant receptors to rescue the haploinsufficient, notched-wing phenotype resulting from loss of one Notch allele (N54l9/+) |
| GO:0035239 tube morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'tube morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0035282 segmentation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'segmentation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0036011 imaginal disc-derived leg segmentation | IMP PMID:10357895 Notch-mediated segmentation and growth control of the Drosop... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived leg segmentation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10357895 By analyzing both loss-of-function and ectopic expression experiments, we show that the Notch signaling pathway plays a fundamental role in the segmentation and growth of the Drosophila leg |
| GO:0036099 female germ-line stem cell population maintenance | IMP PMID:25521289 Notch signaling mediates the age-associated decrease in adhe... | KEEP AS NON CORE | Summary: N IMP annotation to 'female germ-line stem cell population maintenance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25521289 In contrast to GSCs, Notch signaling in niche cells (which is required for niche integrity) is decreased with age, thus contributing to age-induced GSC loss |
| GO:0036335 intestinal stem cell homeostasis | IMP PMID:22522699 Drosophila midgut homeostasis involves neutral competition b... | KEEP AS NON CORE | Summary: N IMP annotation to 'intestinal stem cell homeostasis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:22522699 As well as determining the resulting frequency of ISC loss and replacement, we present evidence suggesting that the process of neutral competition is regulated at the molecular level by Dl/N-mediated lateral inhibition |
| GO:0036335 intestinal stem cell homeostasis | IMP PMID:25166757 Integration of UPRER and oxidative stress signaling in the c... | KEEP AS NON CORE | Summary: N IMP annotation to 'intestinal stem cell homeostasis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25166757 See also Figure S1, S2.Modulating Xbp1 activity further influenced the growth of ISC/EE tumors that accumulate due to defective EB differentiation in Notch loss of function conditions: While spliced Xbp1 prevented tumor formation, loss of Xbp1 exacerbated the growth of these tumors (Figure S2C) |
| GO:0038023 signaling receptor activity | IEA GO_REF:0000117 | MODIFY | Summary: Electronic (ARBA) annotation to the general term signaling receptor activity. Reason: Correct but less informative than the experimentally supported transmembrane signaling receptor activity (GO:0004888), which is already annotated from direct evidence; propose the more specific term. Proposed replacements: transmembrane signaling receptor activity Supporting Evidence: PMID:1657403 We find that of the 36 EGF repeats of Notch, only two, 11 and 12, are both necessary and sufficient to mediate interactions with Delta. |
| GO:0040008 regulation of growth | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'regulation of growth'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0040008 regulation of growth | IGI PMID:14592975 scribble mutants cooperate with oncogenic Ras or Notch to ca... | KEEP AS NON CORE | Summary: N IGI annotation to 'regulation of growth'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14592975 scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila |
| GO:0040008 regulation of growth | IMP PMID:14592975 scribble mutants cooperate with oncogenic Ras or Notch to ca... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of growth'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14592975 scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila |
| GO:0042659 regulation of cell fate specification | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'regulation of cell fate specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0042686 regulation of cardioblast cell fate specification | IMP PMID:12756185 Myogenic cells fates are antagonized by Notch only in asymme... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of cardioblast cell fate specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12756185 These progenitors adopt a pericardial cell fate, however, when cell division is blocked in numb mutants or in embryos with constitutive Notch activity |
| GO:0042688 crystal cell differentiation | IMP PMID:12445385 Notch signaling controls lineage specification during Drosop... | KEEP AS NON CORE | Summary: N IMP annotation to 'crystal cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12445385 Notch signaling controls lineage specification during Drosophila larval hematopoiesis |
| GO:0042688 crystal cell differentiation | IMP PMID:12569125 A Serrate-expressing signaling center controls Drosophila he... | KEEP AS NON CORE | Summary: N IMP annotation to 'crystal cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:12569125 We also find that a signaling center expressing the ligand Serrate is important for differentiation and proliferation of larval hemocytes in Drosophila . Results and Discussion Notch and Su(H) are required for hemocyte proliferation and development Morphological and molecular differentiation of hemocytes can be monitored in the larval lymph gland ( Shrestha and Gateff 1982 ) |
| GO:0042691 positive regulation of crystal cell differentiation | IMP PMID:24318532 An unexpected link between notch signaling and ROS in restri... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of crystal cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:24318532 Here we address the role of Notch (N) signaling in lamellocyte differentiation in response to wasp infection |
| GO:0043525 positive regulation of neuron apoptotic process | IMP PMID:19762424 Lineage-specific cell death in postembryonic brain developme... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of neuron apoptotic process'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19762424 Furthermore, we provide evidence that Notch signaling is involved in the regulation of en expression |
| GO:0043697 cell dedifferentiation | IGI PMID:20152183 dFezf/Earmuff maintains the restricted developmental potenti... | KEEP AS NON CORE | Summary: N IGI annotation to 'cell dedifferentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:20152183 How does Erm suppress the dedifferentiation of INPs? Our results show that reduced Notch function can efficiently suppress ectopic neuroblasts in erm mutant brains while constitutive activation of Notch signaling induced the dedifferentiation of INPs (Figures 6Aβ6C) |
| GO:0045165 cell fate commitment | IMP PMID:21965616 Distinct levels of Notch activity for commitment and termina... | KEEP AS NON CORE | Summary: N IMP annotation to 'cell fate commitment'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21965616 We identified the gene GDP-mannose 4,6-dehydratase (Gmd), a modulator of Notch signaling, as being required for commitment but dispensable for terminal differentiation |
| GO:0045316 negative regulation of compound eye photoreceptor development | IMP PMID:16039641 Notch signaling controls proliferation through cell-autonomo... | KEEP AS NON CORE | Summary: N IMP annotation to 'negative regulation of compound eye photoreceptor development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16039641 Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye |
| GO:0045466 R7 cell differentiation | IMP PMID:11463374 Delta/Notch and Boss/Sevenless signals act combinatorially t... | KEEP AS NON CORE | Summary: N IMP annotation to 'R7 cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11463374 Here, we present evidence that the transmembrane ligand Delta (Dl), expressed by the R1/6 pair, activates the receptor Notch (N) in the presumptive R7 cell and constitutes the postulated R1/6-to-R7 signal required in combination with the Boss/Sev signal to specify the R7 fate |
| GO:0045466 R7 cell differentiation | IMP PMID:19118542 The HLH protein Extramacrochaetae is required for R7 cell an... | KEEP AS NON CORE | Summary: N IMP annotation to 'R7 cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19118542 Null mutant clones show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters |
| GO:0045595 regulation of cell differentiation | IMP PMID:20056890 A transient niche regulates the specification of Drosophila ... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:20056890 Because AMPs express Dl and PCs express Gbe+Su(H)lacZ, we investigated the role of Notch signaling in the generation of a PC. Loss-of-function clones of Notch induced in early L1 larvae and analyzed at late L3 lacked a discernible PC, suggesting that Notch signaling is required for PC generation (Fig. 1, E and F) |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:26887408 Notch stimulates growth by direct regulation of genes involv... | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:26887408 We decided to test whether metabolic genes are direct transcriptional targets of Notch signalling and whether upregulation of metabolic genes can help Notch to induce tissue growth under physiological conditions and in conditions of Notch-induced hyperplasia PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:0045893 positive regulation of DNA-templated transcription | NAS PMID:21737682 Structural and functional analysis of the repressor complex ... | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:21737682 DISCUSSIONCSL is the nuclear effector of the Notch signaling pathway and is required for both repression and activation of transcription from Notch target genes (Kovall and Blacklow, 2010) PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:11390662 A human protein with sequence similarity to Drosophila maste... | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. These results indicate that Mam is an essential component of the transcriptional apparatus of Notch signaling |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:12556495 Signal-induced transcriptional activation by Dif requires th... | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:12556495 Because Armadillo/Ξ²-catenin and Notch are the nuclear end points of these signaling pathways, respectively, TRAP230 and TRAP240 may serve as direct binding targets for and control transcriptional activation by these activators PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000117 | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:11166182 A model Notch response element detects Suppressor of Hairles... | ACCEPT | Summary: NICD positively regulates transcription of Notch target genes (E(spl) complex and others) through Su(H)/CSL. Reason: Consistent with the coactivator activity of NICD in the Su(H)-NICD-Mam complex. The more specific term positive regulation of transcription of Notch receptor target (GO:0007221) also applies (asserted in core functions). Supporting Evidence: PMID:11166182 Our results clearly demonstrate that Su(H) is able to function as the core of a molecular switch, repressing transcription in the absence of Notch and activating in the presence of Notch PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:0046331 lateral inhibition | TAS PMID:12879451 The formation of sense organs in Drosophila: a logical appro... | ACCEPT | Summary: Notch is the receptor mediating lateral inhibition between equipotent cells, e.g. during neuroblast and sensory organ precursor selection. Reason: Lateral inhibition is the paradigmatic Notch-mediated process in Drosophila neurogenesis and is directly executed by Delta-Notch signaling. Accepted. |
| GO:0046666 retinal cell programmed cell death | TAS PMID:12547518 Patterning the fly eye: the role of apoptosis. | KEEP AS NON CORE | Summary: N TAS annotation to 'retinal cell programmed cell death'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0046667 compound eye retinal cell programmed cell death | TAS PMID:11735386 Cell proliferation, survival, and death in the Drosophila ey... | KEEP AS NON CORE | Summary: N TAS annotation to 'compound eye retinal cell programmed cell death'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0046716 muscle cell cellular homeostasis | IMP PMID:29629869 A population of adult satellite-like cells in Drosophila is ... | KEEP AS NON CORE | Summary: N IMP annotation to 'muscle cell cellular homeostasis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:29629869 Furthermore, phenotypes from depletion of zfh1 in MPs, were reminiscent of those elicited by loss of Notch (N) signaling (Figure 1 and KrejcΓ et al., 2009) |
| GO:0046843 dorsal appendage formation | IMP PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anter... | KEEP AS NON CORE | Summary: N IMP annotation to 'dorsal appendage formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16223477 Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis |
| GO:0048052 R1/R6 cell differentiation | IMP PMID:19118542 The HLH protein Extramacrochaetae is required for R7 cell an... | KEEP AS NON CORE | Summary: N IMP annotation to 'R1/R6 cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19118542 Null mutant clones show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters |
| GO:0048056 R3/R4 cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'R3/R4 cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048056 R3/R4 cell differentiation | IMP PMID:10028968 Asymmetric Notch activation specifies photoreceptors R3 and ... | KEEP AS NON CORE | Summary: N IMP annotation to 'R3/R4 cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10028968 Here we identify Notch and Delta (Dl) as dominant enhancers of the phenotypes produced by overexpression of fz and dishevelled (dsh), which encodes a signalling component downstream of Fz, and we show that D1-mediated activation of Notch is required for establishment of ommatidial polarity |
| GO:0048190 wing disc dorsal/ventral pattern formation | IMP PMID:16049109 Influence of Notch on dorsoventral compartmentalization and ... | KEEP AS NON CORE | Summary: N IMP annotation to 'wing disc dorsal/ventral pattern formation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16049109 Activation of the Notch receptor is required for dorsoventral (DV) compartmentalization of the Drosophila wing, but the nature of its requirement has been controversial |
| GO:0048477 oogenesis | IMP PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior... | KEEP AS NON CORE | Summary: N IMP annotation to 'oogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:14536057 A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila |
| GO:0048542 lymph gland development | IMP PMID:15286786 Evidence for a fruit fly hemangioblast and similarities betw... | KEEP AS NON CORE | Summary: N IMP annotation to 'lymph gland development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15286786 In addition, the GATA factor gene pannier (pnr) and the homeobox gene tinman (tin), which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), Wingless (Wg) and Notch signaling, are required for the development of all cardiogenic mesoderm, including the lymph gland |
| GO:0048565 digestive tract development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'digestive tract development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048568 embryonic organ development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'embryonic organ development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048598 embryonic morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'embryonic morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048608 reproductive structure development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'reproductive structure development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048627 myoblast development | IEP PMID:16643882 Notch pathway repression by vestigial is required to promote... | KEEP AS NON CORE | Summary: N IEP annotation to 'myoblast development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:16643882 Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster |
| GO:0048663 neuron fate commitment | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'neuron fate commitment'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048664 neuron fate determination | IMP PMID:9917364 Mastermind acts downstream of notch to specify neuronal cell... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuron fate determination'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:9917364 By contrast, expression of a dominant activated form of the Notch receptor in the MP2 lineage transforms dMP2 to vMP2 |
| GO:0048665 neuron fate specification | IMP PMID:8755475 Numb antagonizes Notch signaling to specify sibling neuron c... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuron fate specification'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:8755475 Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is required to specify dMP2 fate |
| GO:0048732 gland development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'gland development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048749 compound eye development | IMP PMID:19415625 On the mechanism underlying the divergent retinal and bristl... | KEEP AS NON CORE | Summary: N IMP annotation to 'compound eye development'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19415625 R8/SOP selection involves inhibitory Notch (N) signaling between the future R8/SOP and its immediate neighbors in a PNC (reviewed in (Artavanis-Tsakonas et al., 1999; Bray, 2006; Mumm and Kopan, 2000)) |
| GO:0048803 imaginal disc-derived male genitalia morphogenesis | IMP PMID:21729695 UVRAG is required for organ rotation by regulating Notch end... | KEEP AS NON CORE | Summary: N IMP annotation to 'imaginal disc-derived male genitalia morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21729695 These specific and strong genetic interactions between UVRAG and Notch suggest that Notch is the key downstream target of UVRAG.UVRAG regulates organ rotation by inhibiting Notch activityWe then assessed whether the organ rotation defect in UVRAG mutants is also caused by deregulated Notch signaling |
| GO:0048863 stem cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'stem cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0048863 stem cell differentiation | IMP PMID:17070683 Stem cells signal to the niche through the Notch pathway in ... | KEEP AS NON CORE | Summary: N IMP annotation to 'stem cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:17070683 Importantly, clonal analysis reveals that the receiving end of the Notch pathway is required in the somatic cells |
| GO:0050699 WW domain binding | IDA PMID:17656366 Specificity and autoregulation of Notch binding by tandem WW... | KEEP AS NON CORE | Summary: Notch intracellular region binds the tandem WW domains of the HECT E3 ligase Su(dx). Reason: The interaction mediates Su(dx)-dependent ubiquitination and endosomal regulation of Notch; Notch is the substrate here, so the binding is real but regulatory and non-core. Supporting Evidence: PMID:17656366 Su(dx) colocalizes with Notch at the adherens junction either at the cell membrane or in vesicles close to the membrane and has been detected in a complex with Notch, a direct or indirect association that requires the WW domains |
| GO:0050767 regulation of neurogenesis | IMP PMID:19956683 Notch mRNA expression in Drosophila embryos is negatively re... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of neurogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19956683 Interference with this suppression, by a mutation, results in increased levels of polyadenylated Notch mRNA, excess Notch signaling, and severe developmental defects |
| GO:0050768 negative regulation of neurogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'negative regulation of neurogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0050768 negative regulation of neurogenesis | IMP PMID:19701455 In vivo analysis of the Notch receptor S1 cleavage. | KEEP AS NON CORE | Summary: N IMP annotation to 'negative regulation of neurogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:19701455 We also examined the ability of the mutant receptors to rescue the haploinsufficient, notched-wing phenotype resulting from loss of one Notch allele (N54l9/+) |
| GO:0050769 positive regulation of neurogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'positive regulation of neurogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0050793 regulation of developmental process | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: N IEA annotation to 'regulation of developmental process'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0050877 nervous system process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'nervous system process'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0050877 nervous system process | IMP PMID:11711879 Requirement of Notch in adulthood for neurological function ... | KEEP AS NON CORE | Summary: N IMP annotation to 'nervous system process'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:11711879 A progressive neurological syndrome with loss of flight and shortened lifespan was observed in adults with compromised Notch function |
| GO:0051489 regulation of filopodium assembly | IMP PMID:21447553 How Notch establishes longitudinal axon connections between ... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of filopodium assembly'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21447553 Either signaling mechanism provides substantial rescue of a Notch mutant, but both are required for full activity in formation of longitudinal connections of the CNS. The mechanism that guides the very first axon to establish the path of a nascent nerve is one of the most fundamental problems in neural development |
| GO:0060250 germ-line stem-cell niche homeostasis | IMP PMID:25521289 Notch signaling mediates the age-associated decrease in adhe... | KEEP AS NON CORE | Summary: N IMP annotation to 'germ-line stem-cell niche homeostasis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25521289 In contrast to GSCs, Notch signaling in niche cells (which is required for niche integrity) is decreased with age, thus contributing to age-induced GSC loss |
| GO:0060288 formation of a compartment boundary | IMP PMID:21795284 Notch-mediated repression of bantam miRNA contributes to bou... | KEEP AS NON CORE | Summary: N IMP annotation to 'formation of a compartment boundary'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:21795284 Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing |
| GO:0060289 compartment boundary maintenance | IMP PMID:28708823 Notch-dependent epithelial fold determines boundary formatio... | KEEP AS NON CORE | Summary: N IMP annotation to 'compartment boundary maintenance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28708823 By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold |
| GO:0060571 morphogenesis of an epithelial fold | IMP PMID:28708823 Notch-dependent epithelial fold determines boundary formatio... | KEEP AS NON CORE | Summary: N IMP annotation to 'morphogenesis of an epithelial fold'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28708823 By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold |
| GO:0061331 epithelial cell proliferation involved in Malpighian tubule morphogenesis | IMP PMID:11861476 A genetic hierarchy establishes mitogenic signalling and mit... | KEEP AS NON CORE | Summary: N IMP annotation to 'epithelial cell proliferation involved in Malpighian tubule morphogenesis'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:0061382 Malpighian tubule tip cell differentiation | IMP PMID:10625542 Multiple signalling pathways establish cell fate and cell nu... | KEEP AS NON CORE | Summary: N IMP annotation to 'Malpighian tubule tip cell differentiation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:10625542 In embryos mutant for Notch tip cells segregate at the expense of sibling cells, whereas in numb neither daughter cell adopts the tip cell fate resulting in tubules with two sibling cells |
| GO:0097150 neuronal stem cell population maintenance | IGI PMID:28350987 The Super Elongation Complex Drives Neural Stem Cell Fate Co... | KEEP AS NON CORE | Summary: N IGI annotation to 'neuronal stem cell population maintenance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28350987 SEC is highly expressed in neuroblasts, where it promotes self-renewal by physically associating with Notch transcription activation complex and enhancing HES (hairy and E(spl)) transcription |
| GO:0097150 neuronal stem cell population maintenance | IMP PMID:28350987 The Super Elongation Complex Drives Neural Stem Cell Fate Co... | KEEP AS NON CORE | Summary: N IMP annotation to 'neuronal stem cell population maintenance'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28350987 SEC is highly expressed in neuroblasts, where it promotes self-renewal by physically associating with Notch transcription activation complex and enhancing HES (hairy and E(spl)) transcription |
| GO:0120035 regulation of plasma membrane bounded cell projection organization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: N IEA annotation to 'regulation of plasma membrane bounded cell projection organization'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. |
| GO:1900087 positive regulation of G1/S transition of mitotic cell cycle | IMP PMID:15175253 The mitotic-to-endocycle switch in Drosophila follicle cells... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of G1/S transition of mitotic cell cycle'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15175253 The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions |
| GO:1900087 positive regulation of G1/S transition of mitotic cell cycle | IMP PMID:15809036 Extracellular signals responsible for spatially regulated pr... | KEEP AS NON CORE | Summary: N IMP annotation to 'positive regulation of G1/S transition of mitotic cell cycle'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:15809036 Cell cycle entry is induced by Notch signaling and opposed in subsets of cells by EGF receptor activity |
| GO:1902692 regulation of neuroblast proliferation | IGI PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: N IGI annotation to 'regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:27151950 Notch signaling is crucial for maintaining neural stem cell (NSC) self-renewal and heterogeneity; however, the underlying mechanism is not well understood |
| GO:1902692 regulation of neuroblast proliferation | IGI PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: N IGI annotation to 'regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:27151950 Notch signaling is crucial for maintaining neural stem cell (NSC) self-renewal and heterogeneity; however, the underlying mechanism is not well understood |
| GO:1902692 regulation of neuroblast proliferation | IGI PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: N IGI annotation to 'regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:27151950 Notch signaling is crucial for maintaining neural stem cell (NSC) self-renewal and heterogeneity; however, the underlying mechanism is not well understood |
| GO:1902692 regulation of neuroblast proliferation | IMP PMID:27151950 Notch maintains Drosophila type II neuroblasts by suppressin... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:27151950 Notch signaling is crucial for maintaining neural stem cell (NSC) self-renewal and heterogeneity; however, the underlying mechanism is not well understood |
| GO:1902692 regulation of neuroblast proliferation | IMP PMID:28899667 bHLH-O proteins balance the self-renewal and differentiation... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of neuroblast proliferation'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:28899667 These results suggest that both Dpn and Notch signaling are required to completely suppress Erm expression in type II NBs and these molecules may not be totally functionally redundant.Removing Erm prevents the transformation and premature loss of type II NBs resulting from the loss of DpnMisexpression of Erm in type II NBs is detrimental |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IDA PMID:11390662 A human protein with sequence similarity to Drosophila maste... | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:11390662 Expression of a human sequence related to Drosophila Mam (hMam-1) in mammalian cells augments induction of Hairy Enhancer of split (HES) promoters by Notch signaling. hMam-1 stabilizes and participates in the DNA binding complex of the intracellular domain of human Notch1 and a CSL protein PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IDA PMID:25650119 Thermodynamic binding analysis of Notch transcription comple... | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:25650119 Signaling through the Notch pathway ultimately results in changes in gene expression, which is regulated by the transcription factor CSL. Upon pathway activation, CSL forms a ternary complex with the intracellular domain of the Notch receptor (NICD) and the transcriptional coactivator Mastermind (MAM) that activates transcription from Notch target genes PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IDA PMID:29478922 Activation of the Notch Signaling Pathway InΒ Vivo Elicits Ch... | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IEA GO_REF:0000117 | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IPI PMID:21737682 Structural and functional analysis of the repressor complex ... | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:21737682 On pathway activation, the ICN binds CSL, and together with Mam, forms a transcriptionally active ternary complex that ultimately displaces corepressors from CSL and upregulates transcription from Notch target genes PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:1990433 CSL-Notch-Mastermind transcription factor complex | IPI PMID:21737682 Structural and functional analysis of the repressor complex ... | ACCEPT | Summary: NICD is a subunit of the CSL-Notch-Mastermind transcription factor complex with Su(H) and Mam. Reason: Biochemical and structural studies show Drosophila NICD, Su(H) and Mam form the ternary activator complex on DNA. Supporting Evidence: PMID:21737682 On pathway activation, the ICN binds CSL, and together with Mam, forms a transcriptionally active ternary complex that ultimately displaces corepressors from CSL and upregulates transcription from Notch target genes PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. PMID:29478922 In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notch-ON conditions CSL recruitment increases dramatically at target loci, where complexes have longer dwell times conferred by the Notch co-activator Mastermind. |
| GO:2000035 regulation of stem cell division | IMP PMID:26887495 The sexual identity of adult intestinal stem cells controls ... | KEEP AS NON CORE | Summary: N IMP annotation to 'regulation of stem cell division'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:26887495 Females are, however, more prone to genetically induced tumours; indeed, adult-specific interference with Notch (N) or Apc-ras signalling, previously shown to lead to tissue overgrowth reminiscent of gastrointestinal tumours in females22,23, resulted in hyperplasia of female (but not male) midguts (Fig. 4c, d and Extended Data Fig. 9a-f) |
| GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin | IMP PMID:25521289 Notch signaling mediates the age-associated decrease in adhe... | KEEP AS NON CORE | Summary: N IMP annotation to 'negative regulation of cell-cell adhesion mediated by cadherin'. Loss or gain of Notch function alters this process, one of the many developmental or physiological contexts in which Notch receptor signaling is deployed. Reason: Notch is the single Drosophila Notch receptor and its signaling is used reiteratively in cell-fate decisions, boundary formation, proliferation and differentiation. The annotation is biologically sound, but it records a downstream context of Notch signaling rather than the core molecular role of N (ligand-activated transmembrane receptor whose released intracellular domain is a Su(H)/CSL coactivator). Kept as non-core. Supporting Evidence: PMID:25521289 In contrast to GSCs, Notch signaling in niche cells (which is required for niche integrity) is decreased with age, thus contributing to age-induced GSC loss |
| GO:0007221 positive regulation of transcription of Notch receptor target | IDA PMID:11390662 A human protein with sequence similarity to Drosophila maste... | NEW | Summary: NICD, with Su(H) and Mastermind, directly activates transcription of Notch target genes such as the E(spl) complex. Reason: NICD is a direct participant (coactivator subunit of the DNA-bound activator complex), not merely an upstream requirement, so this precise process term is appropriate; the existing annotations use only the generic positive regulation of RNA polymerase II transcription. Supporting Evidence: PMID:11390662 Furthermore, Drosophila Mam forms a similar complex with the intracellular domain of Drosophila Notch and Drosophila CSL protein during activation of Enhancer of split, the Drosophila counterpart of HES. |
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Download this section (compressed HTML)Q: How do Fringe-dependent GlcNAc elongation of O-fucose and Rumi-dependent O-glucosylation quantitatively shift Notch preference between Delta and Serrate at the Drosophila wing D/V boundary?
Q: What fraction of physiological Notch signaling in vivo arises from ligand-independent endosomal activation versus canonical ligand-induced S2/S3 cleavage?
Experiment: Endogenous tagging of NICD with a cleavage-specific reporter combined with live imaging to quantify S3 cleavage rates in lateral inhibition versus boundary-signaling contexts.
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