FlyBase Gene Report: Dmel\NtR
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Kathy Matthews BDSC Endowment
Using AI to get FlyBase data
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Previous
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FB2026_02
,
released June 18, 2026
Sign In
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Vectors & Constructs
New to Flies?
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FB2026_02
,
released June 18, 2026
Gene: Dmel\NtR
J2G
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General Information
Symbol
Dmel\
NtR
Species
D. melanogaster
Name
NtR
Annotation Symbol
CG6698
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029147
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
(Alliance,
FBgn0029147
)
(FlyBase Automatically Generated Summary)
Contribute a Gene Snapshot for this gene.
All Summaries
Alliance
Auto summary
Gene Group
Interactive Fly
Also Known As
DNtR
Key Links
Genomic Location
Cytogenetic map
58B10-58C1
Sequence location
2R:22,127,808..22,130,184 [+]
Recombination map
(full details)
2-98
RefSeq locus
NT_033778 REGION:
22127808..22130184
Sequence
Gene region
Extended Gene region
CDS
Introns
Exons
Transcripts
Translations
5' UTR
3' UTR
Get Sequence
Get Decorated FASTA
Genomic Maps
JBrowse
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
contributes_to
acetylcholine-gated monoatomic cation-selective channel activity
inferred from biological aspect of ancestor with
PANTHER:PTN001054960
(
GO Reference Genome Project,  2011-
)
enables
extracellular ligand-gated monoatomic ion channel activity
inferred from electronic annotation with
InterPro:IPR006202
,
InterPro:IPR036734
(
InterPro Project Members,  2004-
)
enables
monoatomic ion channel activity
inferred from electronic annotation with
InterPro:IPR006201
(
InterPro Project Members,  2004-
)
enables
neurotransmitter receptor activity
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
enables
transmembrane signaling receptor activity
inferred from electronic annotation with
InterPro:IPR006201
(
InterPro Project Members,  2004-
)
Biological Process (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in
calcium ion transport
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
involved_in
monoatomic ion transmembrane transport
inferred from electronic annotation with
InterPro:IPR006201
(
InterPro Project Members,  2004-
)
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
involved_in
monoatomic ion transport
inferred from electronic annotation with
InterPro:IPR006202
,
InterPro:IPR036734
(
InterPro Project Members,  2004-
)
involved_in
regulation of membrane potential
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
involved_in
synaptic transmission, cholinergic
inferred from biological aspect of ancestor with
PANTHER:PTN001054960
(
GO Reference Genome Project,  2011-
)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
part_of
acetylcholine-gated channel complex
inferred from biological aspect of ancestor with
PANTHER:PTN000435923
(
GO Reference Genome Project,  2011-
)
located_in
membrane
inferred from electronic annotation with
InterPro:IPR006202
,
InterPro:IPR036734
(
InterPro Project Members,  2004-
)
inferred from electronic annotation with
InterPro:IPR006201
,
InterPro:IPR006202
,
InterPro:IPR036734
(
InterPro Project Members,  2004-
)
is_active_in
neuron projection
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
is_active_in
plasma membrane
inferred from biological aspect of ancestor with
PANTHER:PTN001054635
(
GO Reference Genome Project,  2011-
)
is_active_in
synapse
inferred from biological aspect of ancestor with
PANTHER:PTN000434994
(
GO Reference Genome Project,  2011-
)
Gene Group (FlyBase)
UNCLASSIFIED LIGAND-GATED ION CHANNEL SUBUNITS
Protein Family (
UniProt
)
-
Protein Signatures (
InterPro
)
Farnesoic acid O-methyl transferase
Neurotransmitter-gated ion-channel
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Summaries
Automated Description (Alliance of Genome Resources)
(Alliance,
FBgn0029147
)
Automatically Generated Summary (FlyBase)
Gene Group (FlyBase)
UNCLASSIFIED LIGAND-GATED ION CHANNEL SUBUNITS
-
This group comprises ligand-gated ion channel subunits that do not classify under other groups in FlyBase or have not been characterised to allow more specific classification.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2
Please see the
JBrowse view of
Dmel\
NtR
for information on other features
To submit a correction to a gene model please use the
Contact FlyBase
form
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by
AlphaFold
)
(
AlphaFold entry Q9W288
)
If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
Some regions with low pLDDT may be unstructured in isolation.
Experimentally Determined Structures
Crossreferences
Comments on Gene Model
Gene model reviewed during 5.39
Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
NtR-RA
FBtr0071762
NM_143701
1876
585
NtR-RB
FBtr0308350
NM_001259528
1855
578
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
NtR-PA
FBpp0071676
66.9
585
7.15
Q9W288
NP_651958
AAF46805
NtR-PB
FBpp0300669
66.2
578
7.32
A0A0B4K8A6
NP_001246457
AFH08210
Polypeptides with Identical Sequences
None of the polypeptides share 100% sequence identity.
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro
-
A database of protein families, domains and functional sites
Neurotransmitter-gated ion-channel
Neurotransmitter-gated ion-channel ligand-binding domain
Farnesoic acid O-methyl transferase
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
AE013599
/
AAF46805
AF045471
/
AAF18569
AE013599
/
AFH08210
AI535021
AI546689
AW944635
AX155075
AY069859
/
AAL40004
BI566644
BI567206
BI567243
BI575828
BI624522
BI627147
BT133311
CO154965
CO278044
CO318864
CO319504
EC072570
EC227325
EC250272
EC261966
EL880308
EL880309
ES696505
GH943603
GH950004
GH961423
GH973735
GH981563
GH982037
GH983941
UniProt
Q9W288
Q9U598
Q8T9A2
A0A0B4K8A6
Mapped Features
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping
Dmel\NtR
using the
Feature Mapper
tool.
Feature Mapper
External Data
Crossreferences
Eukaryotic Promoter Database
-
A collection of databases of experimentally validated promoters for selected model organisms.
NtR_1
Linkouts
Expression Data
Testis-specificity index
The testis specificity index was calculated from modENCODE tissue expression data by
Vedelek
et al.
, 2018
to indicate the degree of testis enrichment compared to other tissues.
Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
-0.77
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7
--
8
head mesoderm
(
Fisher et al.,  2012
)
embryonic stage 9
--
10
head mesoderm
(
Fisher et al.,  2012
)
embryonic stage 11
--
12
dorsal imaginal tissue
Comment:
reported as dorsal imaginal precursor specific anlage
(
Fisher et al.,  2012
)
gnathal primordium
(
Fisher et al.,  2012
)
labral sensory complex primordium
(
Fisher et al.,  2012
)
plasmatocyte primordium
Comment:
reported as plasmatocytes anlage
(
Fisher et al.,  2012
)
ventral epidermis primordium
(
Fisher et al.,  2012
)
ventral sensory complex anlage
(
Fisher et al.,  2012
)
embryonic stage 13
--
16
embryonic head epidermis
(
Fisher et al.,  2012
)
embryonic head sensory system
(
Fisher et al.,  2012
)
embryonic/larval plasmatocyte
(
Fisher et al.,  2012
)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
•
membrane
(
Aradska et al.,  2015
)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
JBrowse
- Visual display of RNA-Seq signals
View
Dmel\
NtR in JBrowse
RNA-Seq by Region
- Search RNA-Seq expression levels by exon or genomic region
View exonic expression by developmental stage for
Dmel\
NtR
View exonic expression by tissue for
Dmel\
NtR
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See
Gelbart and Emmert, 2013
for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
NtR
External Data and Images
Linkouts
BDGP expression data
-
Patterns of gene expression in Drosophila embryogenesis
FBgn0029147
DRscDB
-
A single-cell RNA-seq resource for data mining and data comparison across species
43935/tissue=All
EMBL-EBI Single Cell Expression Atlas
-
Single cell expression across species
FBgn0029147
FlyAtlas
-
Adult expression by tissue, using Affymetrix Dros2 array
FBgn0029147
FlyAtlas2
-
A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
FBgn0029147
Fly-FISH
-
A database of Drosophila embryo and larvae mRNA localization patterns
CG6698
Flygut
-
An atlas of the Drosophila adult midgut
FBgn0029147
Images
FlyExpress
-
Embryonic expression images (BDGP data)
Show all FlyExpress processed images for
Dmel\NtR
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles
( 0 )
For All Classical and Insertion Alleles Show
Pre-selected data
Choose specific data
Other relevant insertions
Transgenic Constructs
( 4 )
For All Alleles Carried on Transgenic Constructs Show
Pre-selected data
Choose specific data
Transgenic constructs containing/affecting coding region of NtR
Transgenic constructs containing regulatory region of NtR
Aberrations (Deficiencies and Duplications)
( 3 )
Inferred from experimentation
( 3 )
Gene disrupted in
Df(2R)Exel6078
(
Ryder,  2004.4.26
)
Df(2R)Exel7170
(
Ryder,  2004.4.26
)
Gene partially disrupted in
Df(2R)GM130-Δ77
(
Zhou et al.,  2014
)
Inferred from location
( 11 )
Export to HitList
Df(2R)01D01Y-R09
Df(2R)01D01Y-R21
Df(2R)01D01Y-R23
Df(2R)01D01Y-R24
Df(2R)BSC424
Df(2R)BSC597
Df(2R)ED3943
Df(2R)ED3952
Df(2R)Exel6078
Df(2R)Exel7170
Dp(2;3)GV-CH321-34A01
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
, with
Dcr-2
UAS.cDa
,
Scer\GAL4
e22c
,
Scer\GAL4
sqh.PW
NtR
GD2144
viable
, with
Dcr-2
UAS.cDa
,
Scer\GAL4
elav.PLu
NtR
GD2144
viable
, with
Scer\GAL4
Mef2.PR
NtR
GD2144
viable
, with
Scer\GAL4
pnr-MD237
NtR
GD2144
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (22)
Hsap\CHRNA2
2 of 14
Yes
No
Hsap\CHRNA3
2 of 14
Yes
No
Hsap\CHRNA4
2 of 14
Yes
No
Hsap\CHRNA5
2 of 14
Yes
No
Hsap\CHRNA6
2 of 14
Yes
No
Hsap\CHRNA9
2 of 14
Yes
No
Hsap\CHRNA10
2 of 14
Yes
No
Hsap\CHRNB2
2 of 14
Yes
No
1
Hsap\CHRNB3
2 of 14
Yes
No
Hsap\CHRNB4
2 of 14
Yes
No
Hsap\CHRND
2 of 14
Yes
Yes
Hsap\HTR3A
2 of 14
Yes
Yes
Hsap\CHRNA1
1 of 14
No
No
Hsap\CHRNB1
1 of 14
No
No
Hsap\CHRNE
1 of 14
No
Yes
Hsap\GLRA2
1 of 14
No
No
5
Hsap\GLRA3
1 of 14
No
No
Hsap\HTR3B
1 of 14
No
No
Hsap\HTR3C
1 of 14
No
No
Hsap\HTR3D
1 of 14
No
No
Hsap\HTR3E
1 of 14
No
No
Hsap\ZACN
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Chrna3
2 of 14
Yes
No
Rnor\Chrna6
2 of 14
Yes
No
Rnor\Chrna9
2 of 14
Yes
No
Rnor\Chrna10
2 of 14
Yes
No
Rnor\Chrnb2
2 of 14
Yes
No
Rnor\Chrnb3
2 of 14
Yes
No
Rnor\Chrna1
1 of 14
No
No
Rnor\Chrna2
1 of 14
No
No
Rnor\Chrna5
1 of 14
No
No
Rnor\Chrnb1
1 of 14
No
No
Rnor\Chrnd
1 of 14
No
No
Rnor\Chrne
1 of 14
No
No
Rnor\Glra3
1 of 14
No
No
Rnor\Htr3a
1 of 14
No
No
Rnor\Htr3b
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Chrna3
2 of 14
Yes
No
Mmus\Chrna6
2 of 14
Yes
No
Mmus\Chrna9
2 of 14
Yes
No
Mmus\Chrna10
2 of 14
Yes
No
Mmus\Chrnb2
2 of 14
Yes
No
Mmus\Chrnb3
2 of 14
Yes
No
Mmus\Chrnd
2 of 14
Yes
Yes
Mmus\Chrna1
1 of 14
No
No
Mmus\Chrna2
1 of 14
No
No
Mmus\Chrna4
1 of 14
No
No
Mmus\Chrna5
1 of 14
No
No
Mmus\Chrnb1
1 of 14
No
No
Mmus\Chrnb4
1 of 14
No
No
Mmus\Chrne
1 of 14
No
No
Mmus\Chrng
1 of 14
No
No
Mmus\Glra3
1 of 14
No
No
Mmus\Htr3a
1 of 14
No
No
Mmus\Htr3b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\gjb7
2 of 13
Yes
Yes
Xtro\anxa1.1
1 of 13
No
No
Xtro\chrna2
1 of 13
No
No
Xtro\chrna9
1 of 13
No
No
Xtro\chrna10
1 of 13
No
No
Xtro\exoc1
1 of 13
No
No
Xtro\htr3a
1 of 13
No
No
Xtro\LOC100487782
1 of 13
No
No
Xtro\LOC100494266
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\chrna4b
2 of 14
Yes
No
Drer\chrna6
2 of 14
Yes
No
Drer\chrnb1
2 of 14
Yes
Yes
Drer\chrnb2
2 of 14
Yes
No
Drer\chrnb3a
2 of 14
Yes
No
Drer\chrna1
1 of 14
No
No
Drer\chrna2a
1 of 14
No
No
Drer\chrna3
1 of 14
No
No
Drer\chrna5
1 of 14
No
No
Drer\chrna7a
1 of 14
No
No
Drer\chrna8
1 of 14
No
No
Drer\chrna10a
1 of 14
No
No
Drer\chrnb1l
1 of 14
No
No
Drer\chrnb3b
1 of 14
No
No
Drer\chrnb4
1 of 14
No
No
Drer\chrnb5a
1 of 14
No
No
Drer\chrnb5b
1 of 14
No
No
Drer\chrnd
1 of 14
No
No
Drer\chrne
1 of 14
No
No
Drer\chrng
1 of 14
No
No
Drer\glra3
1 of 14
No
No
Drer\htr3a
1 of 14
No
No
Drer\LOC798522
1 of 14
No
No
Drer\LOC101882451
1 of 14
No
No
Drer\LOC110439304
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (53)
Cele\acr-23
3 of 14
Yes
Yes
Cele\lev-8
3 of 14
Yes
No
Cele\acr-2
2 of 14
No
No
Cele\acr-3
2 of 14
No
No
Cele\acr-5
2 of 14
No
No
Cele\acr-6
2 of 14
No
No
Cele\acr-8
2 of 14
No
No
Cele\acr-12
2 of 14
No
No
Cele\acr-17
2 of 14
No
Yes
Cele\acr-18
2 of 14
No
No
Cele\acr-21
2 of 14
No
Yes
Cele\cup-4
2 of 14
No
No
Cele\lgc-4
2 of 14
No
Yes
Cele\lgc-13
2 of 14
No
No
Cele\lgc-14
2 of 14
No
No
Cele\lgc-16
2 of 14
No
No
Cele\lgc-17
2 of 14
No
No
Cele\lgc-18
2 of 14
No
No
Cele\lgc-19
2 of 14
No
No
Cele\lgc-20
2 of 14
No
Yes
Cele\lgc-26
2 of 14
No
No
Cele\lgc-29
2 of 14
No
No
Cele\lgc-30
2 of 14
No
Yes
Cele\unc-29
2 of 14
No
No
Cele\unc-38
2 of 14
No
No
Cele\unc-63
2 of 14
No
No
Cele\acr-7
1 of 14
No
No
Cele\acr-10
1 of 14
No
No
Cele\acr-15
1 of 14
No
No
Cele\acr-19
1 of 14
No
No
Cele\acr-24
1 of 14
No
No
Cele\deg-3
1 of 14
No
No
Cele\eat-2
1 of 14
No
No
Cele\lev-1
1 of 14
No
No
Cele\lgc-1
1 of 14
No
No
Cele\lgc-5
1 of 14
No
No
Cele\lgc-6
1 of 14
No
No
Cele\lgc-7
1 of 14
No
No
Cele\lgc-8
1 of 14
No
No
Cele\lgc-9
1 of 14
No
No
Cele\lgc-10
1 of 14
No
No
Cele\lgc-11
1 of 14
No
No
Cele\lgc-12
1 of 14
No
No
Cele\lgc-15
1 of 14
No
No
Cele\lgc-21
1 of 14
No
No
Cele\lgc-23
1 of 14
No
No
Cele\lgc-24
1 of 14
No
No
Cele\lgc-25
1 of 14
No
No
Cele\lgc-28
1 of 14
No
No
Cele\lgc-31
1 of 14
No
Yes
Cele\lgc-41
1 of 14
No
No
Cele\pbo-5
1 of 14
No
No
Cele\pbo-6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (25)
Agam\AgaP_AGAP010580
6 of 12
Yes
Yes
Agam\AgaP_AGAP000329
2 of 12
No
No
Agam\AgaP_AGAP000966
2 of 12
No
No
Agam\AgaP_AGAP002972
2 of 12
No
No
Agam\AgaP_AGAP002974
2 of 12
No
No
Agam\AgaP_AGAP009493
2 of 12
No
No
Agam\AgaP_AGAP010057
2 of 12
No
No
Agam\AgaP_AGAP010059
2 of 12
No
No
Agam\AgaP_AGAP012581
2 of 12
No
No
Agam\AgaP_AGAP000039
1 of 12
No
No
Agam\AgaP_AGAP000138
1 of 12
No
No
Agam\AgaP_AGAP002971
1 of 12
No
No
Agam\AgaP_AGAP006193
1 of 12
No
Yes
Agam\AgaP_AGAP006194
1 of 12
No
Yes
Agam\AgaP_AGAP006195
1 of 12
No
Yes
Agam\AgaP_AGAP006196
1 of 12
No
Yes
Agam\AgaP_AGAP006197
1 of 12
No
Yes
Agam\AgaP_AGAP006198
1 of 12
No
Yes
Agam\AgaP_AGAP006199
1 of 12
No
Yes
Agam\AgaP_AGAP006200
1 of 12
No
Yes
Agam\AgaP_AGAP006201
1 of 12
No
Yes
Agam\AgaP_AGAP008648
1 of 12
No
Yes
Agam\AgaP_AGAP009604
1 of 12
No
No
Agam\AgaP_AGAP010169
1 of 12
No
No
Agam\AgaP_AGAP010205
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from
OrthoDB:NtR
.
Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (23)
nAChRα1
3 of 13
nAChRα2
3 of 13
nAChRα3
3 of 13
nAChRα4
3 of 13
nAChRβ1
3 of 13
nAChRβ2
3 of 13
nAChRβ3
3 of 13
nAChRα5
2 of 13
nAChRα7
2 of 13
alka
1 of 13
CG6927
1 of 13
CG8916
1 of 13
CG10527
1 of 13
GluClα
1 of 13
Grd
1 of 13
HisCl1
1 of 13
Lcch3
1 of 13
nAChRα6
1 of 13
ort
1 of 13
pHCl-1
1 of 13
pHCl-2
1 of 13
Rdl
1 of 13
SecCl
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology
( 5 )
Human Ortholog
Disease
Evidence
References
CHRND; cholinergic receptor nicotinic delta subunit
model of
congenital myasthenic syndrome 3A
IEA
(
FlyBase,  2019-
)
model of
contractures, pterygia, and spondylocarpotarsal fusion syndrome
IEA
(
FlyBase,  2019-
)
model of
congenital myasthenic syndrome 3C
IEA
(
FlyBase,  2019-
)
model of
congenital myasthenic syndrome 3B
IEA
(
FlyBase,  2019-
)
CHRNA1; cholinergic receptor nicotinic alpha 1 subunit
model of
contractures, pterygia, and spondylocarpotarsal fusion syndrome
IEA
(
FlyBase,  2019-
)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data
obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the
literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID
-
A comprehensive database of gene and protein interactions.
FBgn0029147
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
nuclear_gene
protein_coding_gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-98
Cytogenetic map
58B10-58C1
Sequence location
2R:22,127,808..22,130,184 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
58B10-58C1
Limits computationally determined from genome sequence between
P{EP}CG6393
EP2457
and
P{PZ}ari-2
07768
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
58B-58C
(
Chung,  1998.1.29
)
Experimentally Determined Recombination Data
Location
2-98
(
FlyBase,  2016
)
2-103.8
(
Comeron et al.,  2012
)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (4)
Aberrations including deletions of this gene
Aberrations including duplications of this gene
Bloomington
28037
y
1
v
1
; P{TRiP.JF02872}attP2
82702
y
1
v
1
; P{TKO.GS05044}attP40
VDRC
v108234
P{KK104631}VIE-260B
v3479
w
1118
; P{GD2144}v3479
Genomic Clones
(16)
BACR02O12
CH321-21E1
CH321-22E15
CH321-22N5
CH321-32K18
CH321-34A1
CH321-43M11
CH321-61E12
CH321-65G18
CH322-10O8
CH322-60A10
CH322-113P12
CH322-127G18
CH322-147F2
CH322-175H20
CH322-180L5
List GenBank IDs
Please Note
FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones
(24)
List GenBank IDs
Clones Consistent with Transcripts
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes. Please see
JBrowse
for alignment of the cDNAs and ESTs to the gene model.
cDNA clones, fully sequenced
BDGP DGC clones
SD10415
Other clones
FI19009
Drosophila Genomics Resource Center cDNA clones
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged)
in several different host vectors for subsequent cloning and expression in Drosophila and
Drosophila cell lines.
FBgn0029147
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
RH32148
RH36347
RH37073
RH37132
RH64089
RH68371
SD01385
Other clones
16908
174160
524287
EK128610
EK274539
EK278382
EN05118
IP10136
RP004178301
RP004204581
RP004225473
RP004230595
RP004248968
RP004376796
RP004535642
RNAi and Array Information
Linkouts
DRSC
-
Results frm RNAi screens
FBgn0029147
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
Cell Line Information
Publicly Available Cell Lines
Other Stable Cell Lines
Other Comments
Relationship to Other Genes
Source for database merge of
Source for merge of: NtR CG6698
(
Bayraktaroglu,  2000.8.7
)
Source for merge of: NtR anon-WO0138359.3
(
FlyBase,  1996-
)
Additional comments
Source for merge of NtR anon-WO0138359.3 was sequence comparison ( date:051113 ).
(
FlyBase,  1996-
)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs  (5)
Reported As
Symbol Synonym
CG6698
(
Tsubouchi et al.,  2012
,
Keleman et al.,  2009.8.5
,
Perkins et al.,  2009
)
DNtR
(
Chung,  1998.1.29
)
NTR
(
Zhao and Karpac,  2020
)
NtR
(
Liang et al.,  2025
,
Khalili et al.,  2023
,
Green et al.,  2022
,
Hultmark and Andó,  2022
,
Blatt et al.,  2021
,
Maitra et al.,  2019
,
Teets and Hahn,  2018
,
Transgenic RNAi Project members,  2017-
,
Aradska et al.,  2015
,
Tsubouchi et al.,  2012
,
Kolaczkowski et al.,  2011
,
Kong et al.,  2010
,
Leatherbarrow and Halfon,  2009
,
Behm-Ansmant et al.,  2006
)
anon-WO0138359.3
Name Synonyms
NtR
(
Tsubouchi et al.,  2012
)
Secondary FlyBase IDs
FBgn0034698
FBgn0044797
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 40 )
Sequence Crossreferences
NCBI Gene
-
Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
43935
GenBank Nucleotide
-
A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
AF045471
AI546689
AW944635
AX155075
AY069859
GenBank Protein
-
A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
AAF18569
AAF46805
AAL40004
AFH08210
RefSeq
-
A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
NM_143701
NM_001259528
NP_651958
NP_001246457
UniProt/GCRP
-
The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
Q9W288
UniProt/TrEMBL
-
Automatically annotated and unreviewed records of protein sequence and functional information
A0A0B4K8A6
Q8T9A2
Q9U598
Q9W288
Other crossreferences
AlphaFold DB
-
AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
Q9W288
BDGP expression data
-
Patterns of gene expression in Drosophila embryogenesis
FBgn0029147
DRscDB
-
A single-cell RNA-seq resource for data mining and data comparison across species
43935/tissue=All
EMBL-EBI Single Cell Expression Atlas
-
Single cell expression across species
FBgn0029147
FlyAtlas2
-
A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
FBgn0029147
FlyMine
-
An integrated database for Drosophila genomics
FBgn0029147
InterPro
-
A database of protein families, domains and functional sites
Neurotransmitter-gated ion-channel
Neurotransmitter-gated ion-channel ligand-binding domain
Farnesoic acid O-methyl transferase
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
KEGG Genes
-
Molecular building blocks of life in the genomic space.
dme:Dmel_CG6698
MARRVEL_MODEL
-
MARRVEL (model organism gene)
43935
Linkouts
Drosophila Genomics Resource Center
-
Drosophila Genomics Resource Center (DGRC) cDNA clones
FBgn0029147
DroID
-
A comprehensive database of gene and protein interactions.
FBgn0029147
DRSC
-
Results frm RNAi screens
FBgn0029147
Eukaryotic Promoter Database
-
A collection of databases of experimentally validated promoters for selected model organisms.
NtR_1
FlyAtlas
-
Adult expression by tissue, using Affymetrix Dros2 array
FBgn0029147
FlyCyc Genes
-
Genes from a BioCyc PGDB for Dmel
FBGN0029147
Fly-FISH
-
A database of Drosophila embryo and larvae mRNA localization patterns
CG6698
Flygut
-
An atlas of the Drosophila adult midgut
FBgn0029147
iBeetle-Base
-
RNAi phenotypes in the red flour beetle (Tribolium castaneum)
TC033650
References (41)
Report Sections
Open
Close
General Information
Genomic Location
Function
Summaries
Gene Model and Products
Expression Data
Gene ToolKit
Alleles, Insertions, Constructs, and Aberrations
Classical and Insertion Alleles
Transgenic Constructs
Aberrations (Deficiencies and Duplications)
Variants
Phenotypes
Orthologs
Human Orthologs
Model Organism Orthologs
Other Organism Orthologs
Paralogs
Human Disease Associations
Functional Complementation
Interactions
Physical Interaction report
Genetic interactions
External Data
Pathways
Class of Gene
Genomic Location and Mapping
Stocks and Reagents
Other Comments
Relationship to Other Genes
Nomenclature History
Synonyms and Secondary IDs
Datasets
Crossreferences
References
version FB2026_02, released June 18, 2026
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