The C0P8M6 Pcf11 record encodes an 86-residue protein consisting largely of a CTD-interacting domain. Full-length Drosophila Pcf11 participates in RNA polymerase II transcription termination, but the activities and intracellular distribution of this short translation product are unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000993 RNA polymerase II complex binding | IEA GO_REF:0000002 | UNDECIDED | Summary: The short product contains only a partial CTD-interacting architecture. Reason: A CID hit spanning residues 11-86 supports CTD-interaction potential but does not demonstrate RNA polymerase II complex binding by the exact 86-residue product. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0003723 RNA binding | IDA PMID:16387654 Pcf11 is a termination factor in Drosophila that dismantles ... | UNDECIDED | Summary: Gene-level RNA-binding evidence does not resolve the short product. Reason: PMID:16387654 concerns Pcf11 biochemical activity. The exact benchmark product is only 86 residues and requires construct or isoform mapping before the experimental RNA-binding result can be attributed to it. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0003729 mRNA binding | IEA GO_REF:0000002 | UNDECIDED | Summary: CID architecture alone does not establish mRNA binding. Reason: The truncated domain-bearing record cannot be assumed to retain full-length Pcf11 RNA-binding activity; exact-product or mapped-construct evidence is needed. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0006369 termination of RNA polymerase II transcription | IEA GO_REF:0000002 | UNDECIDED | Summary: Transcription termination is established for Pcf11 biology but unresolved for this short product. Reason: A single 86-residue CID-containing product may not execute the full-length protein function. This is an isoform-resolution limitation and not evidence against the experimentally established gene-level role. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0010467 gene expression | IEA GO_REF:0000117 | UNDECIDED | Summary: Gene-expression participation is too indirect for the exact short record. Reason: The broad computational annotation cannot establish that the 86-residue product is produced or functionally contributes to gene expression in vivo. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0031124 mRNA 3'-end processing | IEA GO_REF:0000002 | UNDECIDED | Summary: Participation in mRNA 3-prime processing is unresolved for the short product. Reason: The source sequence lacks most of the full-length Pcf11 architecture; domain presence does not establish assembly into the processing machinery. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
| GO:0032991 protein-containing complex | IEA GO_REF:0000117 | UNDECIDED | Summary: Complex membership is not established for this exact product. Reason: The 86-residue sequence has a CID-family segment but no exact-product demonstration of complex incorporation. Supporting Evidence: file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR006569; CID_dom. file:DROME/Pcf11/Pcf11-uniprot.txt DR InterPro; IPR008942; ENTH_VHS. file:DROME/Pcf11/Pcf11-uniprot.txt FT DOMAIN 11..86 FT /note="CID" FT /evidence="ECO:0000259|PROSITE:PS51391" |
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