3-phosphoinositide-dependent protein kinase 1 that activates Akt and S6K downstream of insulin/PI3K signaling to drive growth.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004674 protein serine/threonine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: PDK1 is a serine/threonine protein kinase. Reason: UniProt describes PDK1 as a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0035556 intracellular signal transduction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PDK1 participates in intracellular signal transduction. Reason: Insulin receptor transduction is a signal transduction pathway. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. |
| GO:0008286 insulin receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. file:genes/DROME/Pdk1/Pdk1-deep-research-falcon.md In Drosophila cells, dPDK1 activates dAkt and dS6K |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: PDK1 binds nucleotides as part of its kinase catalytic cycle. Reason: The catalytic reaction uses ATP, indicating nucleotide binding. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: PDK1 is a protein kinase. Reason: Protein kinase activity is supported by its serine/threonine kinase function. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: PDK1 is a serine/threonine protein kinase. Reason: UniProt describes PDK1 as a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: PDK1 uses ATP in its catalytic reaction. Reason: The kinase reaction explicitly consumes ATP. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: PDK1 is cytoplasmic. Reason: UniProt reports cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm |
| GO:0006915 apoptotic process | IEA GO_REF:0000043 | MODIFY | Summary: PDK1 regulates apoptosis rather than executing apoptotic processes. Reason: UniProt reports that PDK1 inhibits apoptosis; use the regulation term. Proposed replacements: negative regulation of apoptotic process Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Inhibits apoptosis. |
| GO:0007283 spermatogenesis | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: PDK1 may participate in spermatogenesis. Reason: UniProt notes potential involvement in spermatogenesis. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. |
| GO:0016301 kinase activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: PDK1 has kinase activity. Reason: Protein kinase function implies kinase activity. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: PDK1 is a transferase (kinase) enzyme. Reason: Kinases are transferases that transfer phosphate groups. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0030154 cell differentiation | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Cell differentiation is too general relative to the specific developmental roles reported. Reason: Evidence supports embryonic development and growth control but not a specific differentiation process. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0048638 regulation of developmental growth | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: PDK1 regulates developmental growth via insulin signaling. Reason: Insulin receptor pathway regulated by PDK1 controls growth and organ size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | KEEP AS NON CORE | Summary: PDK1 has protein serine kinase activity. Reason: PDK1 is a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:1901701 cellular response to oxygen-containing compound | IEA GO_REF:0000117 | UNDECIDED | Summary: Cellular response to oxygen-containing compounds is not supported by accessible evidence for PDK1. Reason: No direct evidence for this broad response term was identified in available sources. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. |
| GO:0004676 3-phosphoinositide-dependent protein kinase activity | TAS Reactome:R-DME-110468 | ACCEPT | Summary: PDK1 has 3-phosphoinositide-dependent protein kinase activity. Reason: PDK1 phosphorylates PKB/Akt in a phosphoinositide-dependent manner. Supporting Evidence: PMID:9368760 Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2 |
| GO:0004676 3-phosphoinositide-dependent protein kinase activity | TAS Reactome:R-DME-169827 | ACCEPT | Summary: PDK1 has 3-phosphoinositide-dependent protein kinase activity. Reason: PDK1 phosphorylates PKB/Akt in a phosphoinositide-dependent manner. Supporting Evidence: PMID:9368760 Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2 |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:36899949 Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation ... | ACCEPT | Summary: PDK1 is a serine/threonine protein kinase. Reason: UniProt describes PDK1 as a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. PMID:36899949 Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. |
| GO:0009898 cytoplasmic side of plasma membrane | TAS PMID:36899949 Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation ... | KEEP AS NON CORE | Summary: PDK1 binds phosphoinositides on the cytoplasmic side of the plasma membrane. Reason: PH-domain binding to PIP3 indicates cytoplasmic membrane association. Supporting Evidence: PMID:36899949 Phosphoinositide-dependent kinase 1 (PDK1) contains a pleckstrin homology (PH) domain, which binds to Phosphatidylinositol(3,4,5)-tris-phosphate (PI(3,4,5)P3) |
| GO:1904262 negative regulation of TORC1 signaling | TAS PMID:36899949 Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation ... | MARK AS OVER ANNOTATED | Summary: Negative regulation of TORC1 is not directly supported for PDK1. Reason: The cited study links AMPK to mTOR inhibition; PDK1 phosphorylation of LKB1 reduces AMPK activation, which is inconsistent with TORC1 inhibition. Supporting Evidence: PMID:36899949 Activation of AMPK by low energy supply and phosphorylation of LKB1 results in an inhibition of mTOR |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IGI PMID:11752451 PDK1 regulates growth through Akt and S6K in Drosophila. | KEEP AS NON CORE | Summary: PDK1 phosphorylates Akt/PKB in the PI3K-PKB pathway. Reason: PDK1 phosphorylates PKB/Akt in a phosphoinositide-dependent manner. Supporting Evidence: PMID:9368760 Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2 PMID:11752451 PDK1 regulates growth through Akt and S6K in Drosophila. |
| GO:0046622 positive regulation of organ growth | IMP PMID:11752451 PDK1 regulates growth through Akt and S6K in Drosophila. | KEEP AS NON CORE | Summary: PDK1 promotes organ growth via insulin signaling. Reason: Insulin receptor transduction regulated by PDK1 controls organ size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:11752451 PDK1 regulates growth through Akt and S6K in Drosophila. |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:10823906 Use of double-stranded RNA interference in Drosophila cell l... | KEEP AS NON CORE | Summary: PDK1 phosphorylates Akt/PKB in the PI3K-PKB pathway. Reason: PDK1 phosphorylates PKB/Akt in a phosphoinositide-dependent manner. Supporting Evidence: PMID:9368760 Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2 PMID:10823906 Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. |
| GO:0045793 positive regulation of cell size | TAS Reactome:R-DME-110468 | KEEP AS NON CORE | Summary: PDK1 promotes cell size via insulin signaling and S6K/Akt activation. Reason: PDK1 acts in insulin receptor signaling that regulates cell growth and size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:10823906 Use of double-stranded RNA interference in Drosophila cell l... | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:10823906 Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:14645523 Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in... | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:14645523 Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:16627617 TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2... | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:16627617 TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apo... | ACCEPT | Summary: PDK1 is a serine/threonine protein kinase. Reason: UniProt describes PDK1 as a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Serine/threonine kinase required for embryonic development. PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but ... | ACCEPT | Summary: PDK1 functions in the insulin receptor signaling pathway. Reason: UniProt explicitly places PDK1 in insulin receptor transduction controlling growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. |
| GO:0030307 positive regulation of cell growth | IMP PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apo... | KEEP AS NON CORE | Summary: PDK1 promotes cell growth downstream of insulin signaling. Reason: PDK1 acts in insulin receptor signaling that regulates cell growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
| GO:0030307 positive regulation of cell growth | IMP PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | KEEP AS NON CORE | Summary: PDK1 promotes cell growth downstream of insulin signaling. Reason: PDK1 acts in insulin receptor signaling that regulates cell growth. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:0040018 positive regulation of multicellular organism growth | IMP PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | KEEP AS NON CORE | Summary: PDK1 contributes to organismal growth downstream of insulin signaling. Reason: Insulin receptor transduction regulated by PDK1 controls growth and size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:0005634 nucleus | HDA PMID:26896675 A genome-wide resource for the analysis of protein localisat... | UNDECIDED | Summary: Nuclear localization is not supported by the curated UniProt localization statement. Reason: UniProt lists cytoplasmic localization; nuclear evidence is not accessible here. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm PMID:26896675 A genome-wide resource for the analysis of protein localisation in Drosophila. |
| GO:0005737 cytoplasm | HDA PMID:26896675 A genome-wide resource for the analysis of protein localisat... | KEEP AS NON CORE | Summary: PDK1 is cytoplasmic. Reason: UniProt reports cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm PMID:26896675 A genome-wide resource for the analysis of protein localisation in Drosophila. |
| GO:0030295 protein kinase activator activity | IDA PMID:9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): struct... | KEEP AS NON CORE | Summary: PDK1 activates downstream protein kinases such as Akt1 and S6K. Reason: UniProt states PDK1 phosphorylates and activates Akt1 and S6K. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. |
| GO:0046622 positive regulation of organ growth | IMP PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apo... | KEEP AS NON CORE | Summary: PDK1 promotes organ growth via insulin signaling. Reason: Insulin receptor transduction regulated by PDK1 controls organ size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
| GO:0004676 3-phosphoinositide-dependent protein kinase activity | IDA PMID:9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): struct... | ACCEPT | Summary: PDK1 has 3-phosphoinositide-dependent protein kinase activity. Reason: PDK1 phosphorylates PKB/Akt in a phosphoinositide-dependent manner. Supporting Evidence: PMID:9368760 Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2 |
| GO:0005829 cytosol | TAS Reactome:R-DME-110468 | KEEP AS NON CORE | Summary: PDK1 localizes to the cytosol. Reason: Cytosolic localization is consistent with cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-DME-169827 | KEEP AS NON CORE | Summary: PDK1 localizes to the cytosol. Reason: Cytosolic localization is consistent with cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm |
| GO:0005829 cytosol | HDA PMID:25294944 Subcellular localisations of the CPTI collection of YFP-tagg... | KEEP AS NON CORE | Summary: PDK1 localizes to the cytosol. Reason: Cytosolic localization is consistent with cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm PMID:25294944 Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. |
| GO:0031594 neuromuscular junction | IDA PMID:21930778 S6 kinase localizes to the presynaptic active zone and funct... | KEEP AS NON CORE | Summary: PDK1 functions in synapse development at the neuromuscular junction. Reason: PDK1 works with S6K to control synapse development. Supporting Evidence: PMID:21930778 S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. |
| GO:0051124 synaptic assembly at neuromuscular junction | IMP PMID:21930778 S6 kinase localizes to the presynaptic active zone and funct... | KEEP AS NON CORE | Summary: PDK1 contributes to synaptic assembly at the neuromuscular junction. Reason: PDK1 functions with S6K in synapse development at presynaptic active zones. Supporting Evidence: PMID:21930778 S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. |
| GO:0045793 positive regulation of cell size | IGI PMID:19917724 A role for p38 stress-activated protein kinase in regulation... | KEEP AS NON CORE | Summary: PDK1 promotes cell size via insulin signaling and S6K/Akt activation. Reason: PDK1 acts in insulin receptor signaling that regulates cell growth and size. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:19917724 A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: PDK1 is cytoplasmic. Reason: UniProt reports cytoplasmic localization. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: PDK1 associates with the plasma membrane via its PH domain. Reason: PDK1 binds PIP3 via its PH domain, consistent with membrane recruitment. Supporting Evidence: PMID:36899949 Phosphoinositide-dependent kinase 1 (PDK1) contains a pleckstrin homology (PH) domain, which binds to Phosphatidylinositol(3,4,5)-tris-phosphate (PI(3,4,5)P3) |
| GO:0007166 cell surface receptor signaling pathway | IGI PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apo... | KEEP AS NON CORE | Summary: PDK1 participates in cell surface receptor signaling (insulin receptor). Reason: Insulin receptor transduction is a cell-surface receptor signaling pathway. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apo... | KEEP AS NON CORE | Summary: PDK1 inhibits apoptosis. Reason: UniProt states PDK1 inhibits apoptosis. Supporting Evidence: file:genes/DROME/Pdk1/Pdk1-uniprot.txt Inhibits apoptosis. PMID:11344272 Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
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