Rhophilin is a multidomain Rho-effector-family protein containing HR1 Rho-binding, BRO1, and PDZ domains. This architecture supports a signaling scaffold associated with cytoskeletal regulation, while its exact partners and the conservation of stress-fiber regulation in Drosophila remain incompletely resolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0007165 signal transduction | IEA GO_REF:0000002 | ACCEPT | Summary: Signaling participation is supported by the Rho-effector architecture. Reason: HR1 Rho-binding plus BRO1 and PDZ domains support a scaffold role in signal transduction; this is not an intrinsic Rho GTPase activity. Supporting Evidence: file:DROME/Rhp/Rhp-uniprot.txt DR InterPro; IPR004328; BRO1_dom. file:DROME/Rhp/Rhp-uniprot.txt DR InterPro; IPR038499; BRO1_sf. file:DROME/Rhp/Rhp-uniprot.txt FT DOMAIN 36..110 FT /note="REM-1" FT /evidence="ECO:0000259|PROSITE:PS51860" file:DROME/Rhp/Rhp-uniprot.txt FT DOMAIN 121..520 FT /note="BRO1" FT /evidence="ECO:0000259|PROSITE:PS51180" |
| GO:0051497 negative regulation of stress fiber assembly | IBA GO_REF:0000033 | UNDECIDED | Summary: The direction and cellular context of stress-fiber regulation are unresolved. Reason: The existing IBA is a phylogenetic assertion and is not discounted by donor count. HR1/BRO1/PDZ architecture supports Rho-effector biology but does not by itself establish negative regulation of stress-fiber assembly in the exact fly protein; target-specific functional evidence or the ancestral assertion needs resolution. Supporting Evidence: file:DROME/Rhp/Rhp-uniprot.txt DR InterPro; IPR004328; BRO1_dom. file:DROME/Rhp/Rhp-uniprot.txt DR InterPro; IPR038499; BRO1_sf. file:DROME/Rhp/Rhp-uniprot.txt FT DOMAIN 36..110 FT /note="REM-1" FT /evidence="ECO:0000259|PROSITE:PS51860" file:DROME/Rhp/Rhp-uniprot.txt FT DOMAIN 121..520 FT /note="BRO1" FT /evidence="ECO:0000259|PROSITE:PS51180" |
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