id: Q9VKV0
gene_symbol: RluA-1
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Pseudouridine synthesis is supported by target-resolved catalytic conservation and is already
  represented in the annotation record; precise RNA substrates remain unresolved.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/RluA-1/RluA-1-predictions-source.json
references:
- id: PMID:33028630
  title: Loss of Pseudouridine Synthases in the RluA Family Causes Hypersensitive Nociception in Drosophila.
  full_text_unavailable: false
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0001522
    label: pseudouridine synthesis
  predicted_term_type: GO_BP
  review:
    assessment: CNN
    confidence_score: 2
    summary: The pseudouridine-synthesis prediction is supported by the published alignment and structural
      comparison of the exact Q9VKV0 protein, including conserved catalytic residues. This supports the
      shared RluA-family reaction even though specific endogenous RNA targets have not been identified.
      The same process already occurs in the annotation record; its correctness is grounded in catalytic
      conservation rather than that overlap. More specific rRNA/tRNA substrate claims remain unresolved,
      so they are not used to label this prediction less precise.
    supported_by:
    - reference_id: PMID:33028630
      supporting_text: Each of the fully conserved non-catalytic residues (i.e., motif I, Figure 1A) and
        critical residues thought to be important for catalysis (asterisks, Figure 1A) are conserved in
        both RluA-1 and RluA-2.
    - reference_id: PMID:33028630
      supporting_text: leaving to future investigation the nature of their substrates and whether they
        interact with RNA similarly as other synthases