Source: https://flybase.org/reports/FBgn0027080
Retrieved 2026-09-08
FlyBase Gene Report: Dmel\TyrRS Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Sign In Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Gene: Dmel\TyrRS J2G Search Go Open Close General Information Symbol Dmel\ TyrRS Species D. melanogaster Name Tyrosyl-tRNA synthetase Annotation Symbol CG4561 Feature Type protein_coding_gene FlyBase ID FBgn0027080 Gene Model Status Current Stock Availability 7 publicly available Enzyme Name (EC) tyrosine--tRNA ligase
            ( 6.1.1.1 ) Gene Summary (Alliance, FBgn0027080 ) (FlyBase Automatically Generated Summary) Contribute a Gene Snapshot for this gene. All Summaries Alliance Auto summary Gene Group Interactive Fly Also Known As Aats-tyr, dYARS, YARS Key Links Genomic Location Cytogenetic map 72F1-72F1 Sequence location 3L:16,417,349..16,419,302 [-] Recombination map (full details) 3-44 RefSeq locus NT_037436 REGION: 16417349..16419302 Sequence Gene region Extended Gene region CDS Introns Exons Transcripts Translations 5' UTR 3' UTR Get Sequence Get Decorated FASTA Genomic Maps JBrowse Other Genome Views The following external sites may use different assemblies or annotations than FlyBase. NCBI UCSC Ensembl PopFly Function Gene Ontology (GO) Annotations (8 terms) Molecular Function (5 terms) Terms Based on Experimental Evidence (1 term) CV Term Evidence References enables tyrosine-tRNA ligase activity inferred from direct assay ( Storkebaum et al.,  2009 ) Terms Based on Predictions or Assertions (5 terms) CV Term Evidence References enables aminoacyl-tRNA ligase activity inferred from electronic annotation with InterPro:IPR002305 ( InterPro Project Members,  2004- ) enables ATP binding inferred from electronic annotation with InterPro:IPR002305 , InterPro:IPR002307 ( InterPro Project Members,  2004- ) enables nucleotide binding inferred from electronic annotation with InterPro:IPR002305 , InterPro:IPR002307 ( InterPro Project Members,  2004- ) enables tRNA binding inferred from electronic annotation with InterPro:IPR002547 ( InterPro Project Members,  2004- ) enables tyrosine-tRNA ligase activity inferred from biological aspect of ancestor with PANTHER:PTN000236303 ( GO Reference Genome Project,  2011- ) inferred from electronic annotation with InterPro:IPR002307 ( InterPro Project Members,  2004- ) traceable author statement ( Lu et al.,  2015 ) Biological Process (2 terms) Terms Based on Experimental Evidence (0 terms) Terms Based on Predictions or Assertions (2 terms) CV Term Evidence References involved_in tRNA aminoacylation for protein translation inferred from electronic annotation with InterPro:IPR002305 ( InterPro Project Members,  2004- ) involved_in tyrosyl-tRNA aminoacylation inferred from electronic annotation with InterPro:IPR002307 ( InterPro Project Members,  2004- ) traceable author statement ( Lu et al.,  2015 ) Cellular Component (1 term) Terms Based on Experimental Evidence (0 terms) Terms Based on Predictions or Assertions (1 term) CV Term Evidence References located_in cytoplasm traceable author statement ( Lu et al.,  2015 ) Gene Group (FlyBase) CYTOPLASMIC AMINOACYL-TRNA SYNTHETASES Protein Family ( UniProt ) - Protein Signatures ( InterPro ) Aminoacyl-tRNA synthetase, class Ic Nucleic acid-binding, OB-fold Rossmann-like alpha/beta/alpha sandwich fold tRNA-binding domain Tyrosine-tRNA ligase Catalytic Activity ( EC / Rhea ) tyrosine-tRNA ligase activity tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)
            ( 6.1.1.1 ) RHEA 10220 : Summaries Automated Description (Alliance of Genome Resources) (Alliance, FBgn0027080 ) Automatically Generated Summary (FlyBase) Gene Group (FlyBase) CYTOPLASMIC AMINOACYL-TRNA SYNTHETASES - Cytoplasmic aminoacyl-tRNA synthetases catalyze the ligation of amino acids to their cognate tRNAs in the cytoplasm. (Adapted from FBrf0230668 .) Gene Model and Products Number of Transcripts 1 Number of Unique Polypeptides 1 Please see the JBrowse view of Dmel\ TyrRS for information on other features To submit a correction to a gene model please use the Contact FlyBase form Protein Domains (via Pfam) Isoform displayed: Pfam protein domains InterPro name classification start end Protein Domains (via SMART) Isoform displayed: SMART protein domains InterPro name classification start end Structure Protein 3D structure   (Predicted by AlphaFold )  
                    ( AlphaFold entry Q9VV60 ) If you don't see a structure in the viewer, refresh your browser. Model Confidence: Very high (pLDDT > 90) Confident (90 > pLDDT > 70) Low (70 > pLDDT > 50) Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
                          Some regions with low pLDDT may be unstructured in isolation. Experimentally Determined Structures Crossreferences Comments on Gene Model Gene model reviewed during 5.43 Gene model reviewed during 5.44 Transcript Data Annotated Transcripts Name FlyBase ID RefSeq ID Length (nt) Assoc. CDS (aa) TyrRS-RA FBtr0075410 NM_140638 1771 525 Additional Transcript Data and Comments Reported size (kB) Comments External Data Crossreferences Polypeptide Data Annotated Polypeptides Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI UniProt RefSeq ID GenBank TyrRS-PA FBpp0075168 58.2 525 6.86 Q9VV60 NP_648895 AAF49462 Polypeptides with Identical Sequences There is only one protein coding transcript and one polypeptide associated with this gene Additional Polypeptide Data and Comments Reported size (kDa) Comments External Data Crossreferences InterPro -
                  A database of protein families, domains and functional sites Aminoacyl-tRNA synthetase, class Ic Tyrosine-tRNA ligase tRNA-binding domain Nucleic acid-binding, OB-fold Rossmann-like alpha/beta/alpha sandwich fold Linkouts Sequences Consistent with the Gene Model Nucleotide / Polypeptide Records AA264169 AA392520 AA392750 AA696144 AA697091 AA735326 AA802954 AA803946 AA821032 AA941825 AA941897 AE014296 / AAF49462 AF083316 AI063662 AI257542 AI388949 AI402508 AI455095 AI456249 AI512019 AI518188 AI518442 AI518666 AI519977 AI520432 AI534037 AI534221 AI542238 AY051662 / AAK93086 BF497787 BF502792 BF502880 BF505317 BG635425 BG635727 BG635900 BG640603 BG641406 BI163658 BI167824 BI170683 BI215754 BI234871 BI234908 BI236199 BI238901 BI352014 BI352272 BI358340 BI363390 BI364974 BI372143 BI564759 BI565454 BI573646 BI586841 BI592997 BI609094 BI611401 BI612120 BI629332 BI633792 BI634713 BI635649 BI636462 BI636837 BI637109 BI639289 BI639858 BI641716 BP540225 BP540226 BP551256 BP553228 BP553229 BP560097 BQ103236 CO194664 CO270878 CO276592 CO292502 CO305231 CO339941 EC063646 EC065158 EC065816 EC082350 EC083081 EC240953 EV599599 GH756686 GH776109 GH776957 GH777800 GH780365 GH783126 GH783712 GH791279 GH803982 GH809245 GH810593 GH812427 GH814789 GH816124 GH816685 GH817021 GH817087 GH817783 GH820733 GH821063 GH821784 GH823245 GH824093 GH846440 GH851915 GH856017 GH858510 GH858888 GH860855 GH861136 GH861172 GH862553 GH863719 GH865771 GH866880 GH869638 GH870970 GH872679 GH875378 GH877775 GH885918 GH889785 GH890850 GH896222 GH913233 GH914339 GH914860 GH917742 GH922233 GH924052 GH924183 GH924725 GH928270 GH928339 GH928773 GH929389 GH933384 GH934136 GH937581 UniProt Q9VV60 Mapped Features Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping
                        Dmel\TyrRS
                        using the Feature Mapper tool. Feature Mapper External Data Crossreferences Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. Aats-tyr_1 Linkouts Expression Data Testis-specificity index The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al. , 2018 to indicate the degree of testis enrichment compared to other tissues.
                Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias). 0.49 Transcript Expression in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage embryonic/larval salivary gland ( Seshaiah and Andrew,  1999 ) organism | ubiquitous ( Seshaiah and Andrew,  1999 ) embryonic stage 1 -- 3 organism Comment: maternally deposited ( Fisher et al.,  2012 ) embryonic stage 4 -- 6 organism | ubiquitous ( Fisher et al.,  2012 ) embryonic stage 7 -- 8 organism | ubiquitous ( Fisher et al.,  2012 ) embryonic stage 9 -- 10 organism | ubiquitous ( Fisher et al.,  2012 ) embryonic stage 11 -- 12 organism | ubiquitous ( Fisher et al.,  2012 ) embryonic stage 13 -- 16 organism | ubiquitous ( Fisher et al.,  2012 ) Additional Descriptive Data Marker for Subcellular Localization CV Term Polypeptide Expression mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference adult stage adult head • membrane ( Aradska et al.,  2015 ) Additional Descriptive Data Marker for Subcellular Localization CV Term Evidence References Expression Deduced from Reporters High-Throughput Expression Data Associated Tools JBrowse - Visual display of RNA-Seq signals View Dmel\ TyrRS in JBrowse RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region View exonic expression by developmental stage for Dmel\ TyrRS View exonic expression by tissue for Dmel\ TyrRS Bulk Downloads RNA-Seq RPKM values for all genes Reference See Gelbart and Emmert, 2013 for analysis details and data files for all genes. Developmental Proteome: Life Cycle Developmental Proteome: Embryogenesis TyrRS External Data and Images Linkouts BDGP expression data -
                  Patterns of gene expression in Drosophila embryogenesis FBgn0027080 DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 39829/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0027080 FlyAtlas -
                  Adult expression by tissue, using Affymetrix Dros2 array FBgn0027080 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0027080 Fly-FISH -
                  A database of Drosophila embryo and larvae mRNA localization patterns CG4561 Flygut -
                  An atlas of the Drosophila adult midgut FBgn0027080 Images FlyBase Wiki Image Based Resources Alleles, Insertions, Transgenic Constructs, and Aberrations Classical and Insertion Alleles
            ( 0 ) For All Classical and Insertion Alleles Show Pre-selected data Choose specific data Other relevant insertions Transgenic Constructs
            ( 18 ) For All Alleles Carried on Transgenic Constructs Show Pre-selected data Choose specific data Transgenic constructs containing/affecting coding region of TyrRS Transgenic constructs containing regulatory region of TyrRS Aberrations (Deficiencies and Duplications)
              ( 1 ) Inferred from experimentation
                  ( 1 ) Gene disrupted in Df(3L)Exel6129 ( Ryder,  2004.4.26 ) Inferred from location
                  ( 4 ) Export to HitList Df(3L)BSC555 Df(3L)ED4606 Df(3L)Exel6129 Dp(3;2)GV-CH321-68M18 Variants Variant Molecular Consequences Alleles Representing Disease-Implicated Variants Phenotypes For more details about a specific phenotype click on the relevant allele symbol. Lethality Allele lethal , with Dcr-2 UAS.cDa , Scer\GAL4 elav.PLu TyrRS GD11353 lethal , with Scer\GAL4 Act5C.PI TyrRS E195K.UAS lethal , with Scer\GAL4 Act5C.PU TyrRS E195K.UAS TyrRS G40R.UAS lethal , with Scer\GAL4 ap-md544 TyrRS Mini.UAS.Tag:SS(wg) lethal , with Scer\GAL4 pnr-MD237 TyrRS GD11353 lethal - all die during embryonic stage , with Dcr-2 UAS.cDa , Scer\GAL4 elav.PLu TyrRS GD11353 lethal - all die during larval stage , with Scer\GAL4 Mef2.PR TyrRS GD11353 partially lethal - majority die , with Scer\GAL4 Act5C.PI TyrRS 152-155delVKQV.UAS TyrRS G40R.UAS partially lethal - majority die , with Scer\GAL4 Act5C.PU TyrRS 152-155delVKQV.UAS TyrRS E195K.UAS TyrRS G40R.UAS viable , with Scer\GAL4 Act5C.PI TyrRS K264N.UAS TyrRS UAS.cSa viable , with Scer\GAL4 Act5C.PU TyrRS 152-155delVKQV.UAS TyrRS G40R.UAS TyrRS UAS.cSa viable , with Scer\GAL4 nSyb.PS TyrRS K264N.UAS TyrRS UAS.cSa Other Phenotypes Allele abnormal locomotor behavior , with Scer\GAL4 nSyb.PS TyrRS 152-155delVKQV.UAS TyrRS E195K.UAS TyrRS G40R.UAS decreased cell size | cell autonomous | somatic clone , with Scer\GAL4 Act5C.PP TyrRS NIG.4561R increased cell death | somatic clone , with Scer\GAL4 Act5C.PI TyrRS Mini.UAS.Tag:SS(wg) TyrRS UAS.Tag:SS(wg) Phenotype manifest in Allele embryonic/larval hemocyte , with Scer\GAL4 ap-md544 TyrRS EMAP.UAS.Tag:SS(wg) TyrRS UAS.Tag:SS(wg) lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4 Act5C.PP TyrRS NIG.4561R scutellar bristle , with Scer\GAL4 sca.PU TyrRS NIG.4561R Orthologs Downloads Download All DIOPT Orthologs Human Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Homo sapiens (Human) (6) Hsap\YARS1 14 of 14 Yes Yes 12 Hsap\AIMP1 3 of 14 No No Hsap\MARS1 1 of 14 No No Hsap\MARS2 1 of 14 No No 2 Hsap\WARS1 1 of 14 No No Hsap\YARS2 1 of 14 No No Model Organism Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Rattus norvegicus (Norway rat) (6) Rnor\Yars1 14 of 14 Yes Yes Rnor\Aimp1 4 of 14 No No Rnor\Mars1 1 of 14 No No Rnor\Mars2 1 of 14 No No Rnor\Wars1 1 of 14 No No Rnor\Yars2 1 of 14 No No Mus musculus (laboratory mouse) (6) Mmus\Yars 14 of 14 Yes Yes Mmus\Aimp1 3 of 14 No No Mmus\Mars1 1 of 14 No No 2 Mmus\Mars2 1 of 14 No No Mmus\Wars 1 of 14 No No Mmus\Yars2 1 of 14 No No Xenopus tropicalis (Western clawed frog) (3) Xtro\yars1 11 of 13 Yes Yes Xtro\aimp1 3 of 13 No No Xtro\sox17b.1 1 of 13 No No Danio rerio (Zebrafish) (8) Drer\yars1 13 of 14 Yes Yes Drer\aimp1a 4 of 14 No No Drer\aimp1b 4 of 14 No No Drer\mars1 1 of 14 No No Drer\mars2 1 of 14 No No Drer\wars1 1 of 14 No No Drer\wars2 1 of 14 No No Drer\yars2 1 of 14 No No Caenorhabditis elegans (Nematode, roundworm) (4) Cele\yars-1 8 of 14 Yes Yes Cele\mars-1 1 of 14 No No Cele\wars-1 1 of 14 No No Cele\Y105E8A.28 1 of 14 No Yes Anopheles gambiae (African malaria mosquito) (6) Agam\AgaP_AGAP003003 12 of 12 Yes Yes Agam\AgaP_AGAP010586 4 of 12 No No Agam\AgaP_AGAP002383 1 of 12 No No Agam\AgaP_AGAP003315 1 of 12 No No Agam\AgaP_AGAP007891 1 of 12 No No Agam\TTRNA1 1 of 12 No No Arabidopsis thaliana (thale-cress) (10) Atha\AT2G33840 10 of 13 Yes Yes Atha\AT1G28350 9 of 13 No Yes Atha\AT2G40660 5 of 13 No No Atha\AT3G59980 4 of 13 No No Atha\AT4G13780 3 of 13 No No Atha\AT2G33845 1 of 13 No Yes Atha\AT3G04600 1 of 13 No No Atha\AT5G02680 1 of 13 No Yes Atha\EMB2768 1 of 13 No No Atha\OVA1 1 of 13 No No Saccharomyces cerevisiae (Brewer's yeast) (7) Scer\TYS1 11 of 13 Yes Yes Scer\ARC1 5 of 13 No No Scer\MES1 1 of 13 No No Scer\MSM1 1 of 13 No No Scer\MSW1 1 of 13 No No Scer\MSY1 1 of 13 No No Scer\WRS1 1 of 13 No No Schizosaccharomyces pombe (Fission yeast) (7) Spom\yrs1 11 of 12 Yes Yes Spom\SPAC30C2.04 4 of 12 No No Spom\msw1 1 of 12 No No Spom\rar1 1 of 12 No No Spom\SPAC27E2.06c 1 of 12 No No Spom\SPCC576.06c 1 of 12 No No Spom\wrs1 1 of 12 No No Escherichia coli (enterobacterium) (3) Ecol\ygjH 4 of 11 Yes No Ecol\metG 2 of 11 No No Ecol\tyrS 1 of 11 No No Other Organism Orthologs (via OrthoDB) Data provided directly from OrthoDB:TyrRS .
              Refer to their site for version information. Paralogs Downloads Download All DIOPT Paralogs Paralogs (via DIOPT v9.1) Gene Symbol Score Source Compara Domainoid eggNOG Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Drosophila melanogaster (Fruit fly) (5) AIMP1 7 of 13 MetRS 1 of 13 MetRS-m 1 of 13 TrpRS 1 of 13 TyrRS-m 1 of 13 Human Disease Associations FlyBase Human Disease Model Reports Charcot-Marie-Tooth disease, dominant intermediate C Disease Ontology (DO) Annotations Models Based on Experimental Evidence ( 4 ) Allele Disease Evidence References TyrRS K264N.UAS DOES NOT model Charcot-Marie-Tooth disease CEA ( Leitao-Goncalves et al.,  2012 ) TyrRS E195K.UAS model of Charcot-Marie-Tooth disease CEA ( Leitao-Goncalves et al.,  2012 ) TyrRS G40R.UAS model of Charcot-Marie-Tooth disease CEA ( Leitao-Goncalves et al.,  2012 ) TyrRS 152-155delVKQV.UAS model of Charcot-Marie-Tooth disease CEA ( Leitao-Goncalves et al.,  2012 ) Potential Models Based on Orthology
            ( 1 ) Human Ortholog Disease Evidence References YARS1; tyrosyl-tRNA synthetase 1 model of Charcot-Marie-Tooth disease dominant intermediate C IEA ( FlyBase,  2019- ) Modifiers Based on Experimental Evidence ( 1 ) Allele Disease Interaction References TyrRS GD11353 exacerbates cancer modeled by yki S168A.UAS.EGFP,Tag:HA ( Yeom et al.,  2020 ) Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM) Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown. Homo sapiens (Human) Gene name Score OMIM OMIM Phenotype DO term Complementation? Transgene? YARS1; tyrosyl-tRNA synthetase 1 14 of 14 TYROSYL-tRNA SYNTHETASE 1; YARS1 NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET 2; IMNEPD2 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE C; CMTDIC Charcot-Marie-Tooth disease dominant intermediate C AIMP1; aminoacyl tRNA synthetase complex interacting multifunctional protein 1 3 of 14 603605 LEUKODYSTROPHY, HYPOMYELINATING, 3; HLD3 hypomyelinating leukodystrophy 3 Functional Complementation Data Functional complementation data is computed by FlyBase using a combination of the orthology data
                  obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the
                  literature. Dmel gene Ortholog showing functional complementation Supporting References TyrRS Hsap\YARS1 ( Storkebaum et al.,  2009 ) Interactions Summary of Physical Interactions Interaction Browsers View in FlyBase Interactions Browser View in MIST tool (external link) Please see the Physical Interaction reports below for full details protein-protein Physical Interaction Assay References TyrRS - eIF4B experimental knowledge based ( Guruharsha et al.,  2011 ) Summary of Genetic Interactions Interaction Browsers View in FlyBase Interactions Browser View in MIST tool (external link) Please look at the allele data for full details of the genetic interactions Starting gene(s) Interaction type Interacting gene(s) Reference TyrRS suppressible Mmp2 ( Casas-Tintó et al.,  2015 ) Starting gene(s) Interaction type Interacting gene(s) Reference External Data Linkouts BioGRID -
                  A database of protein and genetic interactions. 65135 DroID -
                  A comprehensive database of gene and protein interactions. FBgn0027080 MIST (protein-protein) -
                  An integrated Molecular Interaction Database 39829 Pathways Signaling Pathways (FlyBase) Metabolic Pathways FlyBase External Links FlyCyc Pathways -
                  Pathways from a BioCyc PGDB for Dmel tRNA charging KEGG Metabolic Pathways -
                  A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks. Aminoacyl-tRNA biosynthesis External Data Linkouts KEGG Pathways -
                  A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks. Aminoacyl-tRNA biosynthesis Class of Gene nuclear_gene protein_coding_gene Genomic Location and Detailed Mapping Data Chromosome (arm) 3L Recombination map 3-44 Cytogenetic map 72F1-72F1 Sequence location 3L:16,417,349..16,419,302 [-] FlyBase Computed Cytological Location Cytogenetic map Evidence for location 72F1-72F1 Limits computationally determined from genome sequence between P{lacW}l(3)s3123 s3123 and P{lacW}l(3)j10E8 j10E8 & P{PZ}l(3)10532 10532 Experimentally Determined Cytological Location Cytogenetic map Notes References Experimentally Determined Recombination Data Location 3-44 ( FlyBase,  2016 ) 3-39.0 ( Comeron et al.,  2012 ) Left of (cM) Right of (cM) Notes Stocks and Reagents Stocks (7) Aberrations including deletions of this gene Aberrations including duplications of this gene Bloomington 55326 y 1 v 1 ; P{TRiP.HMC04013}attP40 62899 y 1 v 1 ; P{TRiP.HMJ24139}attP40 79710 y 1 sc * v 1 sev 21 ; P{TOE.GS01506}attP40 NIG-Fly 4561R-2 P{NIG.4561R}2 HMJ24139 y 1 v 1 ; P{TRiP.HMJ24139}attP40/CyO VDRC v105615 P{KK100551}VIE-260B v40541 w 1118 ; P{GD11353}v40541/TM3 Genomic Clones
            (10) BACR09I16 CH321-6G5 CH321-43O22 CH321-73J17 CH321-77E14 CH321-78P20 CH321-87E12 CH321-95N7 CH322-24C9 CH322-118C14 List GenBank IDs Please Note FlyBase no
                        longer curates genomic clone accessions so this list
                        may not be complete cDNA Clones
            (143) List GenBank IDs Clones Consistent with Transcripts Please Note This section lists cDNAs and ESTs that fall within the genomic extent
                        of the gene model, which may include cDNAs and ESTs
                        of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model. cDNA clones, fully sequenced BDGP DGC clones LD21116 Other clones DPiM_LD21116 Drosophila Genomics Resource Center cDNA clones For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged)
                    in several different host vectors for subsequent cloning and expression in Drosophila and
                    Drosophila cell lines. FBgn0027080 cDNA Clones, End Sequenced (ESTs) BDGP DGC clones AT07521 AT12079 AT18612 AT18726 GH03606 GH20011 GH21743 GM05154 GM05448 GM06639 GM09071 GM12333 GM17240 GM18607 LD07937 LD11402 LD11886 LD27229 LD36136 LD37632 LD37954 LD38307 LD39873 LD40592 LD43635 LP05943 RE03111 RE08304 RE12222 RE22354 RE30640 RE30680 RE32229 RE42019 RE45083 RE48183 RE50183 RE59024 RH10852 RH13837 RH17604 RH26951 RH38920 RH40522 RH58177 RH62261 RH63230 SD06511 SD06816 SD08402 SD11728 SD12738 SD12833 SD13205 SD13418 SD17062 SD18146 SD18663 SD19029 SD21839 SD22555 SD25284 SD27952 Other clones 694 72048 106089 125644 AF083316 CK01.34A.F5 CK01.110C.G1 Dmel_neb_011414_0842_3063 EC38990 EK100919 EK121517 EK200330 EK247716 EP09707 FGA001C01 FGM223C10 FGM324F07 LD27125 RP003012685 RP003073056 RP003085734 RP003099849 RP003116137 RP003118916 RP003122790 RP003143534 RP003153124 RP003158158 RP003168768 RP003174481 RP003176029 RP003177963 RP003180662 RP003180769 RP003197007 RP003205591 RP003208288 RP003213599 RP003221322 RP003222399 RP003222425 RP003224887 RP003232206 RP003234529 RP003246675 RP003259858 RP003260094 RP003260801 RP003267091 RP003268305 RP003274016 RP003275228 RP003293268 RP003302125 RP003323629 RP003326220 RP003345728 RP003345886 RP003347784 RP003349141 RP003350619 RP003356219 RP003359731 RP003368106 RP003422371 RP003427008 RP003427444 RP003442331 RP003489848 RP003501418 RP003505124 RP003518706 RP003562377 RP003568821 RP003571906 RP003622153 RP003657384 UUGC0638 RNAi and Array Information Linkouts DRSC -
                  Results frm RNAi screens FBgn0027080 Antibody Information Laboratory Generated Antibodies Commercially Available Antibodies Cell Line Information Publicly Available Cell Lines Other Stable Cell Lines Other Comments Relationship to Other Genes Source for database merge of Source for merge of: Aats-tyr CG4561 ( FlyBase,  1996- ) Source for merge of: CG4561 anon- EST:Posey261 ( Bayraktaroglu,  2000.11.2 ) Additional comments Nomenclature History Source for database identify of Source for identity of: TyrRS Aats-tyr ( Lu et al.,  2015 ) Nomenclature comments Etymology Synonyms and Secondary IDs  (13) Reported As Symbol Synonym Aats-tyr ( Solana-Manrique et al.,  2021 , Zirin et al.,  2019 , Yasunaga et al.,  2014 , Parry et al.,  2010 , Storkebaum et al.,  2009 , Pierce et al.,  2008 , Conant and Wagner,  2005 ) CG4561 ( Lin et al.,  2018 , Yamaguchi and Takashima,  2018 , Çiçek et al.,  2016 , Lu et al.,  2015 , Ni et al.,  2010.12.1 , Keleman et al.,  2009.8.5 , Perkins et al.,  2009 , Gong et al.,  2004 , Giot et al.,  2003 , Pile et al.,  2003 ) EMAP ( Coelho et al.,  2018 ) TyrRS ( Warecki et al.,  2025 , Ecovoiu et al.,  2022 , Yamaguchi et al.,  2021 , Kitani-Morii and Noto,  2020 , Zirin et al.,  2019 , Bussmann and Storkebaum,  2017 , Transgenic RNAi Project members,  2017- , Clavería and Torres,  2016 , Storkebaum,  2016 , Casas-Tintó et al.,  2015 , Lu et al.,  2015 , Leitao-Goncalves et al.,  2012 , Storkebaum et al.,  2009 , Seshaiah and Andrew,  1999.7.29 ) YARS ( Li et al.,  2020 , Leitao-Goncalves et al.,  2012 ) YRS ( Seshaiah and Andrew,  1999 ) anon-EST:Posey261 dTyrRS ( Storkebaum et al.,  2009 ) dYARS ( Ermanoska et al.,  2023 , Morant et al.,  2021 , Wu et al.,  2019 , Yasunaga et al.,  2014 , Leitao-Goncalves et al.,  2012 , Storkebaum et al.,  2009 , Storkebaum et al.,  2009 ) dYARS1 ( Ermanoska et al.,  2023 ) Name Synonyms Tyrosyl-tRNA synthetase ( Yamaguchi and Takashima,  2018 , Casas-Tintó et al.,  2015 , Lu et al.,  2015 , Seshaiah and Andrew,  1999 ) tyrosyl-tRNA synthetase ( Leitao-Goncalves et al.,  2012 , Storkebaum et al.,  2009 ) yars ( Kitani-Morii and Noto,  2020 ) Secondary FlyBase IDs FBgn0025537 FBgn0036630 Datasets (0) Study focus (0) Experimental Role Project Project Type Title Study result (0) Result Result Type Title External Crossreferences and Linkouts ( 39 ) Sequence Crossreferences NCBI Gene -
                  Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide. 39829 GenBank Nucleotide -
                  A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB. AA697091 AA735326 AF083316 AI455095 AY051662 GenBank Protein -
                  A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB. AAF49462 AAK93086 RefSeq -
                  A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein. NM_140638 NP_648895 UniProt/GCRP -
                  The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene. Q9VV60 UniProt/TrEMBL -
                  Automatically annotated and unreviewed records of protein sequence and functional information Q9VV60 Other crossreferences AlphaFold DB -
                  AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research. Q9VV60 BDGP expression data -
                  Patterns of gene expression in Drosophila embryogenesis FBgn0027080 DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 39829/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0027080 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0027080 FlyMine -
                  An integrated database for Drosophila genomics FBgn0027080 InterPro -
                  A database of protein families, domains and functional sites Aminoacyl-tRNA synthetase, class Ic Tyrosine-tRNA ligase tRNA-binding domain Nucleic acid-binding, OB-fold Rossmann-like alpha/beta/alpha sandwich fold KEGG Genes -
                  Molecular building blocks of life in the genomic space. dme:Dmel_CG4561 MARRVEL_MODEL -
                  MARRVEL (model organism gene) 39829 Linkouts BioGRID -
                  A database of protein and genetic interactions. 65135 Drosophila Genomics Resource Center -
                  Drosophila Genomics Resource Center (DGRC) cDNA clones FBgn0027080 DroID -
                  A comprehensive database of gene and protein interactions. FBgn0027080 DRSC -
                  Results frm RNAi screens FBgn0027080 Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. Aats-tyr_1 FlyAtlas -
                  Adult expression by tissue, using Affymetrix Dros2 array FBgn0027080 FlyCyc Genes -
                  Genes from a BioCyc PGDB for Dmel FBGN0027080 FlyCyc Pathways -
                  Pathways from a BioCyc PGDB for Dmel tRNA charging Fly-FISH -
                  A database of Drosophila embryo and larvae mRNA localization patterns CG4561 Flygut -
                  An atlas of the Drosophila adult midgut FBgn0027080 iBeetle-Base -
                  RNAi phenotypes in the red flour beetle (Tribolium castaneum) TC013181 KEGG Metabolic Pathways -
                  A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks. Aminoacyl-tRNA biosynthesis KEGG Pathways -
                  A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks. Aminoacyl-tRNA biosynthesis MIST (protein-protein) -
                  An integrated Molecular Interaction Database 39829 References (71) Report Sections Open Close General Information Genomic Location Function Summaries Gene Model and Products Expression Data Gene ToolKit Alleles, Insertions, Constructs, and Aberrations Classical and Insertion Alleles Transgenic Constructs Aberrations (Deficiencies and Duplications) Variants Phenotypes Orthologs Human Orthologs Model Organism Orthologs Other Organism Orthologs Paralogs Human Disease Associations Functional Complementation Interactions Physical Interaction report Genetic interactions External Data Pathways Class of Gene Genomic Location and Mapping Stocks and Reagents Other Comments Relationship to Other Genes Nomenclature History Synonyms and Secondary IDs Datasets Crossreferences References version FB2026_02, released June 18, 2026 Contact FlyBase FAQ Citing FlyBase