id: A0A0B4LHX6
gene_symbol: awd
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: 'The ProtNLM2 API snapshot retrieved 2026-09-08 contains no GO-term predictions for A0A0B4LHX6.
  Nucleoside diphosphate kinase activity (GO:0004550) is a strongly supported omission candidate: purified
  Drosophila awd protein has the activity, and the selected 168-residue product contains the entire characterized
  153-residue enzyme sequence, including its catalytic histidine and nucleotide-binding positions. The
  disagreement between FlyBase and reviewed UniProt about N-terminal initiation does not alter that conserved
  catalytic core; the historical prediction-time sequence is not established by the current comparison.
  The separate FUNCTION paragraph describing NDP-kinase phosphate transfer is CNN. This completed record
  assesses the absence of GO output; predictions is empty because no GO or EC prediction was emitted.
  The narrative judgment remains in the linked function review and is not a score assigned to the omission.'
source_documents:
- genes/DROME/awd/awd-protnlm-source.json
- projects/PROTNLM_EVALUATION/fly-benchmark/manifest.json
- genes/DROME/awd/awd-protnlm-function-review.md
- genes/DROME/awd/awd-uniprot.txt
- genes/DROME/awd/awd-bioinformatics/RESULTS.md
- publications/PMID_1320004.md
references:
- id: file:DROME/awd/awd-bioinformatics/RESULTS.md
  title: awd exact-isoform sequence comparison
  findings:
  - statement: The selected protein retains the complete characterized enzyme sequence and mapped catalytic
      residues.
    supporting_text: The 168-residue awd-PC/PD protein A0A0B4LHX6 contains the entire 153-residue reviewed
      P08879 sequence unchanged, preceded by a 15-residue N-terminal extension. Catalytic His119 maps
      to target His134; all seven annotated nucleotide-binding positions are preserved.
- id: PMID:1320004
  title: A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation
    killer of prune) affects stability but not catalytic efficiency of the enzyme.
  findings:
  - statement: Primary work purified the Drosophila nucleoside diphosphate kinase from larvae.
    supporting_text: 'We purified the nucleoside

      diphosphate kinases from wild-type and mutant larvae by a simple procedure

      involving affinity chromatography on blue Sepharose.'
  full_text_unavailable: true
predictions: []