id: Q8MST5
gene_symbol: betaTub97EF
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: A broad microtubule role is supported for both internal splice variants; microtubule-based
  process is less precise than the supported organization annotation.
source_documents:
- genes/DROME/betaTub97EF/betaTub97EF-predictions-source.json
- genes/DROME/betaTub97EF/betaTub97EF-uniprot-source.json
references:
- id: PMID:29084803
  title: Drosophila β-Tubulin 97EF is upregulated at low temperature and stabilizes microtubules.
  full_text_unavailable: false
  findings: []
- id: file:DROME/betaTub97EF/betaTub97EF-literature/PMID_29084803-excerpts.md
  title: DROME/betaTub97EF/betaTub97EF-literature/PMID_29084803-excerpts.md
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/betaTub97EF/betaTub97EF-predictions-source.json
  predicted_term:
    id: GO:0007017
    label: microtubule-based process
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: A microtubule-based process is supported by the intact beta-tubulin architecture and primary
      experiments on both internal splice variants. Both forms partially rescue loss of the major betaTub56D
      paralog; the detailed stabilization and cold-induction results specifically concern the major exon-4B
      form. Exact correspondence of Q8MST5 to the paper’s exon names remains unresolved, but this does
      not undermine the broad structural microtubule role. Existing microtubule-cytoskeleton organization
      is a more precise supported process, so the prediction is LSP.
    supported_by:
    - reference_id: PMID:29084803
      supporting_text: Changing β-tubulin isoform ratios in hemocytes demonstrated that β-Tubulin 97EF
        has a pronounced microtubule stabilizing effect.
    - reference_id: PMID:29084803
      supporting_text: βTub97EF is required for normal microtubule stability in the gut.
    - reference_id: file:DROME/betaTub97EF/betaTub97EF-literature/PMID_29084803-excerpts.md
      supporting_text: UASt-βTub97EF(4B) and UASt-βTub97EF(4C) provided only limited rescue.