id: Q9VEC5
gene_symbol: cdm
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Both broad transport predictions are correct but less precise than the characterized nuclear
  cargo-transport function.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/cdm/cdm-predictions-source.json
references:
- id: PMID:20122403
  title: Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin
    13.
  full_text_unavailable: true
  findings: []
- id: PMID:11447110
  title: 'Importin 13: a novel mediator of nuclear import and export.'
  full_text_unavailable: true
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0006913
    label: nucleocytoplasmic transport
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Nucleocytoplasmic transport is supported by the direct fly Imp13-Mago-Y14 import complex
      and the conserved bidirectional importin-13 cycle. It is broader than the existing protein-import
      and export annotations.
    supported_by:
    - &id001
      reference_id: PMID:20122403
      supporting_text: 'The heterodimer is imported back into the nucleus by Importin 13

        (Imp13), a member of the karyopherin-beta family of transport factors. We have

        elucidated the structural basis of the Mago-Y14 nuclear import cycle. The 3.35 A

        structure of the Drosophila Imp13-Mago-Y14 complex shows that Imp13 forms a

        ring-like molecule, reminiscent of Crm1, and encircles the Mago-Y14 cargo with a

        conserved interaction surface.'
    - reference_id: PMID:11447110
      supporting_text: Imp13 also shows export activity towards the translation initiation factor eIF1A
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0006886
    label: intracellular protein transport
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Cadmus directly carries Mago-Y14 in nuclear import. Intracellular protein transport is correct
      but less specific than the supported nuclear-import annotation already in GOA.
    supported_by:
    - *id001