id: Q9V4C9
gene_symbol: dati
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The known transcription-regulatory DNA-binding role is supported; specific activating activity
  remains unresolved.
source_documents:
- genes/DROME/dati/dati-predictions-source.json
- genes/DROME/dati/dati-uniprot-source.json
references:
- id: PMID:11867614
  title: DNA binding and gene activation properties of the Nmp4 nuclear matrix transcription factors.
  full_text_unavailable: true
  findings: []
- id: PMID:25291190
  title: The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons
    for sexual receptivity in Drosophila females.
  findings: []
  full_text_unavailable: false
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/dati/dati-predictions-source.json
  predicted_term:
    id: GO:0001228
    label: DNA-binding transcription activator activity, RNA polymerase II-specific
  predicted_term_type: GO_MF
  review:
    assessment: UNC
    confidence_score: 1
    summary: A transcription-regulatory role is well supported, but the specific claim of transcriptional
      activation remains unresolved. The target primary study establishes neuronal specification and identifies
      its zinc-finger family without measuring activation of a defined target promoter. Related Nmp4/ZNF384
      proteins can activate transcription in a context-dependent manner, which does not establish activation
      by Dati. The raw donor ZNF208 is a different zinc-finger protein and cannot supply a target-specific
      regulatory direction.
    supported_by:
    - &id001
      reference_id: PMID:25291190
      supporting_text: dati encodes a zinc finger transcription factor closely related to rotund (rn)
        and squeeze (sqz) with homologs in several species, including humans
    - &id002
      reference_id: PMID:25291190
      supporting_text: Here we described DATI, a zinc finger transcription factor related to the Drosophila
        Rotund and Squeeze and the vertebrate ZNF384
    - reference_id: PMID:11867614
      supporting_text: the native Nmp4 protein up-regulated transcription
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/dati/dati-predictions-source.json
  predicted_term:
    id: GO:0000978
    label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  predicted_term_type: GO_MF
  review:
    assessment: CNN
    confidence_score: 2
    summary: Dati is a nuclear zinc-finger transcriptional regulator related to Rotund/Squeeze and vertebrate
      ZNF384, with a retained C2H2 finger array. Direct DNA-binding studies of the characterized Nmp4/ZNF384
      family support transfer of the broad cis-regulatory DNA-binding mechanism; the neuronal specification
      phenotype supplies coherent target biological context. This is an evolutionary inference rather
      than a mapped Dati binding motif or target promoter. The same broad DNA-binding transcription-regulatory
      role was already established in the Dati literature before the prediction, so this is correct but
      not novel; activation versus repression remains unresolved.
    supported_by:
    - *id001
    - *id002
    - reference_id: PMID:11867614
      supporting_text: Zinc fingers 2, 3, and 6 mediated association with the homopolymeric (dA.dT) COL1A1/MMP
        DNA consensus element.