id: M9NFK2
gene_symbol: ftz-f1
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: 'The ProtNLM2 API snapshot retrieved 2026-09-08 contains no GO-term predictions for M9NFK2.
  DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), and nucleus (GO:0005634)
  are supported omission candidates: primary FTZ-F1 DNA-binding/reporter experiments and betaFTZ-F1 nuclear
  localization complement exact sequence identity to reviewed P33244-2 and retention of the shared DNA-binding
  domain. This does not transfer every expression pattern of the longer isoform or establish the historical
  predictor input. Nuclear-receptor family membership alone does not establish ligand-regulated transcription.
  The separate FUNCTION paragraph supports broad transcriptional regulation but has a PLI judgment for
  high-affinity thyroid-hormone receptor specificity. This completed record assesses the absence of GO
  output; predictions is empty because no GO or EC prediction was emitted. The narrative judgments remain
  in the linked function review and are not scores assigned to the omission.'
source_documents:
- genes/DROME/ftz-f1/ftz-f1-isoform-records/M9NFK2-protnlm.json
- projects/PROTNLM_EVALUATION/fly-benchmark/manifest.json
- genes/DROME/ftz-f1/ftz-f1-protnlm-function-review.md
- genes/DROME/ftz-f1/ftz-f1-uniprot.txt
- genes/DROME/ftz-f1/ftz-f1-isoform-records/README.md
- publications/PMID_2113881.md
- publications/PMID_11060234.md
references:
- id: file:DROME/ftz-f1/ftz-f1-isoform-records/README.md
  title: FTZ-F1 accession and isoform sequence comparison
  findings:
  - statement: The selected accession has exact sequence identity to reviewed isoform P33244-2.
    supporting_text: It is exactly identical to M9NFK2 (803/803 aa; SHA256 `8e47b8779f9e0ee27c6b92a56b1170a84a3c05cd7eade1dd500c5d6d3c6082b7`).
- id: PMID:2113881
  title: A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression.
  findings:
  - statement: Purified FTZ-F1 recognizes specific regulatory DNA.
    supporting_text: 'We have purified to homogeneity a sequence-specific DNA-binding

      factor, FTZ-F1, that binds to two sites located within the zebra element and to

      two sites within the ftz protein-coding sequence.'
  - statement: Recognition-site mutations impair both binding and reporter expression.
    supporting_text: 'the

      binding to FTZ-F1 is disrupted in vitro, and the intensity of lacZ expression is

      reduced in transformed embryos'
  full_text_unavailable: true
- id: PMID:11060234
  title: 'Temporally restricted expression of transcription factor betaFTZ-F1: significance for embryogenesis,
    molting and metamorphosis in Drosophila melanogaster.'
  findings:
  - statement: The developmental betaFTZ-F1 isoform localizes to nuclei.
    supporting_text: 'We found that an isoform of FTZ-F1, betaFTZ-F1, is

      expressed in the nuclei of almost all tissues slightly before the first and

      second larval ecdysis and before pupation.'
  full_text_unavailable: true
predictions: []