Headbutt is a 451-residue Rost-family protein with six predicted transmembrane helices. It is an integral membrane protein with an unresolved molecular activity and biological role for this isoform.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0003674 molecular_function | ND GO_REF:0000015 | ACCEPT | Summary: Molecular activity remains unknown. Reason: Six membrane-spanning segments and a Rost-family domain do not establish a transporter substrate or catalytic activity. Supporting Evidence: file:DROME/hbt/hbt-uniprot.txt DR InterPro; IPR049352; Rost. file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 40..63 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 75..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" |
| GO:0008150 biological_process | ND GO_REF:0000015 | ACCEPT | Summary: Biological process remains unknown. Reason: The exact Headbutt isoform lacks a sufficiently grounded physiological function in the retrieved evidence. Supporting Evidence: file:DROME/hbt/hbt-uniprot.txt DR InterPro; IPR049352; Rost. file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 40..63 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 75..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" |
| GO:0016020 membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Membrane association is well supported by architecture. Reason: The six Phobius transmembrane segments between residues 40 and 250 independently support the existing ISS membrane annotation. The membrane identity and transport activity are unresolved. Supporting Evidence: file:DROME/hbt/hbt-uniprot.txt DR InterPro; IPR049352; Rost. file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 40..63 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/hbt/hbt-uniprot.txt FT TRANSMEM 75..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" |
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