id: Q9XTP7
gene_symbol: jumu
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The DNA-binding prediction is supported but less precise than the directly characterized
  sequence-specific enhancer-binding function.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/jumu/jumu-predictions-source.json
references:
- id: PMID:22378636
  title: Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead
    transcription factors.
  full_text_unavailable: false
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0043565
    label: sequence-specific DNA binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: Sequence-specific DNA binding is directly supported by the Jumu/Forkhead-site analysis of
      the Nidogen enhancer. Jumu cooperates with CHES-1-like in cardiac repression, with distinct binding-site
      combinations determining regulatory activity. The existing cis-regulatory region sequence-specific
      DNA-binding annotation is more informative than the broad prediction.
    supported_by:
    - reference_id: PMID:22378636
      supporting_text: 'CHES-1-like cooperates with Jumu to repress this enhancer in the

        heart.'
    - reference_id: PMID:22378636
      supporting_text: 'different combinations of Fkh sites, corresponding to two different sequence

        specificities, mediate the particular functions of each TF.'