id: X2J5X6
gene_symbol: loqs
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Broad regulation of gene expression is supported by conserved miRNA-processing biology, but
  is less precise than the existing pre-miRNA-processing annotations.
source_documents:
- genes/DROME/loqs/loqs-protnlm-source.json
- genes/DROME/loqs/loqs-bioinformatics/RESULTS.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/loqs/loqs-protnlm-source.json
  predicted_term:
    id: GO:0010468
    label: regulation of gene expression
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Loqs-PF retains all three domains of the experimentally characterized PB miRNA-processing
      cofactor, differing by one linker-region lysine. Primary experiments demonstrate Loqs-dependent
      regulation of miRNA-target expression. Existing annotations include the more informative pre-miRNA-processing
      function, as well as the broad predicted term itself. LSP therefore reflects a correct but less
      precise description; ARBA agreement is not treated as validation. The mammalian pathway wording
      in the separate narrative prediction does not invalidate this broad GO claim.
    supported_by:
    - reference_id: PMID:15918769
      supporting_text: 'These results support a model in which Loquacious mediates

        miRNA biogenesis and, thereby, the expression of genes regulated by miRNAs.'
    - reference_id: file:DROME/loqs/loqs-bioinformatics/RESULTS.md
      supporting_text: All three annotated DRBM domains are fully retained.
references:
- id: PMID:15918769
  title: Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells.
  findings: []
- id: file:DROME/loqs/loqs-bioinformatics/RESULTS.md
  title: RESULTS.md
  findings: []