id: A1Z8G0
gene_symbol: metro
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Cell-junction localization is supported by the demonstrated perisynaptic scaffold and is
  less precise than existing cell-cell-junction localization.
source_documents:
- genes/DROME/metro/metro-predictions-source.json
- genes/DROME/metro/metro-uniprot-source.json
references:
- id: PMID:20427642
  title: A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of
    Drosophila synaptic junctions.
  findings: []
  full_text_unavailable: true
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/metro/metro-predictions-source.json
  predicted_term:
    id: GO:0030054
    label: cell junction
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Cell-junction localization is biologically supported by direct identification of Metro at
      larval neuromuscular junctions and its junctional scaffold complex. It is broader than the existing
      cell-cell-junction annotation, so the prediction is less precise. The source ARBA cell-junction
      row is annotation overlap only; the primary experiment provides independent support.
    supported_by:
    - reference_id: PMID:20427642
      supporting_text: In this study we have identified Metro, a novel p55/MPP-like Drosophila MAGUK as
        a major binding partner of perisynaptic DlgS97 at larval NMJs.
    - reference_id: PMID:20427642
      supporting_text: Based on homotypic LIN-2,-7 (L27) domain interactions, Metro stabilizes junctional
        DlgS97 in a complex with the highly conserved adaptor protein DLin-7.