id: Q9VSD6
gene_symbol: msk
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The general intracellular protein-transport prediction is supported but less precise than
  the established nuclear-import function.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/msk/msk-predictions-source.json
references:
- id: PMID:11262240
  title: Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin.
  full_text_unavailable: true
  findings: []
- id: PMID:23885126
  title: Identification and characterization of Drosophila Snurportin reveals a role for the import receptor
    Moleskin/importin-7 in snRNP biogenesis.
  full_text_unavailable: false
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0006886
    label: intracellular protein transport
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Intracellular protein transport is directly supported by the loss of activated ERK nuclear
      import in moleskin mutants and rescue by wild-type DIM-7. A second primary study identifies Moleskin
      association with snurportin/snRNP cargo and an snRNP-import defect. The existing protein import
      into nucleus annotation is more specific than the predicted general intracellular transport.
    supported_by:
    - reference_id: PMID:11262240
      supporting_text: 'Deletion or mutation of moleskin dramatically reduces the nuclear localization

        of activated D-ERK. Directly linking DIM-7 to its nuclear import, this defect

        can be rescued by the expression of wild-type DIM-7.'
    - reference_id: PMID:23885126
      supporting_text: 'the importin-7 orthologue Moleskin

        (Msk) physically associates with both dSNUP and spliceosomal snRNPs and

        localizes to nuclear Cajal bodies.'