id: Q8IMZ2
gene_symbol: orb
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Orb is an experimentally established CPEB-family RNA-binding translation regulator, and the
  same GO term already occurs in the selected record.
source_documents:
- genes/DROME/orb/orb-predictions-source.json
- genes/DROME/orb/orb-uniprot-source.json
references:
- id: PMID:15737929
  title: The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory
    pathway.
  findings: []
  full_text_unavailable: true
- id: PMID:27791065
  title: RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2.
  full_text_unavailable: true
  findings: []
- id: file:DROME/orb/orb-bioinformatics/RESULTS.md
  title: DROME/orb/orb-bioinformatics/RESULTS.md
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/orb/orb-predictions-source.json
  predicted_term:
    id: GO:0045182
    label: translation regulator activity
  predicted_term_type: GO_MF
  review:
    assessment: CNN
    confidence_score: 2
    summary: Orb is an experimentally established CPEB-family RNA-binding translation regulator, and the
      same GO term already occurs in the selected record. Direct RNA-target profiling and germline translational
      studies support correctness independently of that electronic annotation. Q8IMZ2 is shorter at the
      N-terminus but retains the complete C-terminal RNA-binding machinery, making transfer of this broad
      function reasonable. The prediction adds no novel activity.
    supported_by:
    - reference_id: PMID:27791065
      supporting_text: Both Orb and Orb2 bind linear cytoplasmic polyadenylation element-like sequences
        in the 3' UTRs of largely overlapping target mRNAs, with Orb2 potentially having a broader specificity.
    - reference_id: PMID:15737929
      supporting_text: Orb is responsible for mediating the translational activation of mRNAs localized
        within the developing oocyte.
    - reference_id: file:DROME/orb/orb-bioinformatics/RESULTS.md
      supporting_text: The complete 552-residue C-terminal region (target 8–559, reference 364–915) is
        identical.