id: Q9W255
gene_symbol: qkr58E-1
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: qkr58E-1 is a nuclear KH-domain RNA-binding protein associated with spliceosomes. The broad
  RNA-binding and gene-expression predictions are supported but less precise than existing functional
  assignments.
source_documents:
- genes/DROME/qkr58E-1/qkr58E-1-protnlm-source.json
- genes/DROME/qkr58E-1/qkr58E-1-uniprot.txt
- genes/DROME/qkr58E-1/qkr58E-1-nature20568.txt
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/qkr58E-1/qkr58E-1-protnlm-source.json
  predicted_term:
    id: GO:0010468
    label: regulation of gene expression
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Spliceosomal processing and regulation of alternative mRNA splicing support a role in gene
      expression; existing GOA contains the more precise splicing assignments.
    supported_by:
    - &id002
      reference_id: PMID:18981222
      supporting_text: 'Here we affinity purified Drosophila melanogaster

        spliceosomal B and C complexes formed in Kc cell nuclear extract.'
    - &id001
      reference_id: file:DROME/qkr58E-1/qkr58E-1-uniprot.txt
      supporting_text: DR   InterPro; IPR004087; KH_dom.
    - reference_id: file:DROME/qkr58E-1/qkr58E-1-nature20568.txt
      supporting_text: Three proteins, Hrb27C, Qkr58E-1 and Nito, in addition to m 6 A components, control
        fl(2)d splicing in the same direction.
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/qkr58E-1/qkr58E-1-protnlm-source.json
  predicted_term:
    id: GO:0003723
    label: RNA binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: RNA binding is supported by the intact KH domain and spliceosome association. Existing mRNA-binding
      annotation is more informative.
    supported_by:
    - *id001
    - *id002
    - reference_id: PMID:26294687
      supporting_text: We find reciprocal RNA binding between the pairs of SYP and QKR58E-1, as well as
        QKR54B and QKR58E-1.
references:
- id: PMID:18981222
  title: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster
    and human spliceosomal complexes.
  findings: []
- id: file:DROME/qkr58E-1/qkr58E-1-uniprot.txt
  title: qkr58E-1-uniprot.txt
  findings: []
- id: file:DROME/qkr58E-1/qkr58E-1-nature20568.txt
  title: Primary publisher text and Extended Data of PMID:27919077
  findings: []
- id: PMID:26294687
  title: Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila.
  findings: []