Regeneration is a secretory-pathway C-type-lectin-domain protein implicated in imaginal-disc regeneration. Genetic perturbation affects blastema formation and growth, while its ligand specificity and the relationship between the 808-residue isoform and its inferred trans-Golgi localization remain unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005802 trans-Golgi network | IBA GO_REF:0000033 | UNDECIDED | Summary: Trans-Golgi-network residence is unresolved for the exact long isoform. Reason: The IBA is a curated phylogenetic assertion. The 808-residue record contains an N-terminal signal peptide and a C-type lectin domain; those features establish secretory-pathway compatibility but do not distinguish soluble secretion from Golgi residence. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
| GO:0030140 trans-Golgi network transport vesicle | IBA GO_REF:0000033 | UNDECIDED | Summary: Transport-vesicle residence needs a resolved localization inference. Reason: A signal peptide and lectin fold do not identify a trans-Golgi transport vesicle. No exact-isoform localization experiment or resolved ancestral assertion is available in the inspected evidence. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
| GO:0030246 carbohydrate binding | IEA GO_REF:0000104 | UNDECIDED | Summary: A C-type lectin-like fold does not establish carbohydrate binding. Reason: Several proteins retain this fold without the canonical carbohydrate-binding activity. The exact target has no mapped ligand-binding assay. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
| GO:0030246 carbohydrate binding | ISS PMID:16475980 Participation of a galactose-specific C-type lectin in Droso... | UNDECIDED | Summary: The ISS lectin-binding transfer needs more specific support. Reason: PMID:16475980 directly assays DL1 and discusses Drosophila lectins. It supplies useful family biology but does not establish carbohydrate binding by the long Rgn isoform; target-specific ligand or conserved-binding-site evidence is required. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
| GO:0042246 tissue regeneration | IEP PMID:18485344 Three genes control the timing, the site and the size of bla... | KEEP AS NON CORE | Summary: Regeneration-associated expression supports physiological context. Reason: PMID:18485344 reports rgn expression in regenerating blastema cells. Expression alone does not define a molecular function; the accompanying genetic evidence supports the biological role. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
| GO:0042246 tissue regeneration | IMP PMID:18485344 Three genes control the timing, the site and the size of bla... | ACCEPT | Summary: Rgn contributes to imaginal-disc regeneration. Reason: The full text of PMID:18485344 maps rgn alleles to CG6014 and reports altered blastema regeneration after genetic perturbation. The gene-level process is well supported although the molecular mechanism and isoform contributions remain unresolved. Supporting Evidence: file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR001304; C-type_lectin-like. file:DROME/rgn/rgn-uniprot.txt DR InterPro; IPR016186; C-type_lectin-like/link_sf. file:DROME/rgn/rgn-uniprot.txt FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" file:DROME/rgn/rgn-uniprot.txt FT DOMAIN 70..199 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" PMID:18485344 We identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration. |
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