rl encodes Rolled, the Drosophila ERK-family MAP kinase activated by Dsor1/MEK in receptor-driven Ras/MAPK pathways. Activated Rolled phosphorylates cytoplasmic and nuclear substrates, including transcriptional regulators, to execute EGFR, Sevenless, Torso, FGF, Pvr, insulin, and stress-associated signaling outputs.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000165 MAPK cascade | IMP PMID:8033205 The activities of two Ets-related transcription factors requ... | ACCEPT | Summary: Rolled participates in the canonical MAPK cascade downstream of Ras/Raf/MAPKK. Reason: Rolled is the MAP kinase in the Drosophila Ras1/MAPK pathway; the seeded IMP row is broad but still directly captures the signaling cascade in which rl acts. Supporting Evidence: PMID:8033205 Ras1/MAPK pathway |
| GO:0000278 mitotic cell cycle | IMP PMID:16308331 MAP kinase subcellular localization controls both pattern an... | KEEP AS NON CORE | Summary: Rolled nuclear/cytoplasmic localization contributes to proliferative wing MAPK outputs. Reason: Mitotic-cell-cycle effects arise from tissue-specific ERK signaling in the developing wing, not from a separate core cell-cycle function of Rolled. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: InterPro correctly identifies a protein kinase domain but maps to the overly broad parent protein kinase activity. Reason: Rolled/ERK-A is the Drosophila ERK MAP kinase and is repeatedly assayed or modeled as the GO:0004707 kinase in receptor-tyrosine-kinase MAPK signaling. The broad kinase parent is correct but should be replaced by the specific MAP kinase activity term. Proposed replacements: MAP kinase activity |
| GO:0004674 protein serine/threonine kinase activity | IBA GO_REF:0000033 | MODIFY | Summary: PAINT supports conserved serine/threonine MAP kinase catalysis but the parent serine/threonine kinase term is too broad. Reason: Rolled/ERK-A is the Drosophila ERK MAP kinase and is repeatedly assayed or modeled as the GO:0004707 kinase in receptor-tyrosine-kinase MAPK signaling. The broad kinase parent is correct but should be replaced by the specific MAP kinase activity term. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN000622075 SUPPORTS TRANSFER PAINT supports a conserved MAPK catalytic activity for the ERK/JNK/p38 family, but the MAP kinase activity child is the more informative catalytic term for rolled. Proposed replacements: MAP kinase activity |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:18216172 Multiple RTK pathways downregulate Groucho-mediated repressi... | MODIFY | Summary: The IDA row supports Rolled kinase activity at a level better represented by MAP kinase activity. Reason: Rolled/ERK-A is the Drosophila ERK MAP kinase and is repeatedly assayed or modeled as the GO:0004707 kinase in receptor-tyrosine-kinase MAPK signaling. The broad kinase parent is correct but should be replaced by the specific MAP kinase activity term. Proposed replacements: MAP kinase activity |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:27601662 Minibrain and Wings apart control organ growth and tissue pa... | MODIFY | Summary: The paper assays Minibrain/Wings apart phosphorylation of Capicua, but Rolled is a MAP kinase and the parent term is only too broad. Reason: GO:0004674 is true for Rolled but less informative than GO:0004707 MAP kinase activity; the row should be narrowed rather than removed, even though this specific reference centers on Mnb/Wap phosphorylation of Cic rather than a direct Rolled kinase assay. Proposed replacements: MAP kinase activity Supporting Evidence: PMID:27601662 Mnb and Wap bind to and phosphorylate the Cic protein |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:8946916 The Drosophila Jun-N-terminal kinase is required for cell mo... | UNDECIDED | Summary: The cached record is abstract-only and foregrounds Basket/D-JNK, so the Rolled-specific assay cannot be verified. Reason: Because the FlyBase curator may have used a full-text Rolled assay that is not exposed in the cached abstract, this experimental annotation should not be removed from abstract-only evidence. Supporting Evidence: PMID:8946916 The Drosophila Jun-N-terminal kinase is required for cell morphogenesis |
| GO:0004707 MAP kinase activity | IDA PMID:10394362 PTP-ER, a novel tyrosine phosphatase, functions downstream o... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:10394362 PTP-ER dramatically inhibits RAS1/MAPK signaling |
| GO:0004707 MAP kinase activity | IDA PMID:11357138 Mae mediates MAP kinase phosphorylation of Ets transcription... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. |
| GO:0004707 MAP kinase activity | IDA PMID:16362034 Mae inhibits Pointed-P2 transcriptional activity by blocking... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:16362034 requires a three-dimensional docking surface on its SAM domain for the MAP kinase, Rolled |
| GO:0004707 MAP kinase activity | IDA PMID:7601354 Secreted Spitz triggers the DER signaling pathway and is a l... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:7601354 activation of MAP kinase is observed |
| GO:0004707 MAP kinase activity | IDA PMID:8033205 The activities of two Ets-related transcription factors requ... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:8033205 Ras1/MAPK pathway |
| GO:0004707 MAP kinase activity | IDA PMID:8047146 The ETS domain protein pointed-P2 is a target of MAP kinase ... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:8047146 The PntP2 protein is phosphorylated by Rl/MAP kinase in vitro |
| GO:0004707 MAP kinase activity | IDA PMID:8798773 Biochemical characterization of rolledSem, an activated form... | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. Supporting Evidence: PMID:8798773 Biochemical characterization of rolledSem |
| GO:0004707 MAP kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: The annotation captures the core MAP kinase activity of Rolled/ERK-A. Reason: The cited evidence is direct evidence for Rolled as the ERK-family MAP kinase. This activity is the gene product's core molecular function in the Ras/Raf/Dsor1/Rolled cassette. |
| GO:0005515 protein binding | IPI PMID:16763554 Inhibition of ERK-MAP kinase signaling by RSK during Drosoph... | MODIFY | Summary: The S6kII/RSK interaction is a specific kinase-to-kinase interaction, not an uninformative bare binding function. Reason: The paper supports a physical association between Rolled/ERK and the protein kinase S6kII/RSK during feedback inhibition of ERK signaling, so GO:0019901 is more informative than GO:0005515. Proposed replacements: protein kinase binding Supporting Evidence: PMID:16763554 physical association between ERK and RSK |
| GO:0005515 protein binding | IPI PMID:17255944 A MAPK docking site is critical for downregulation of Capicu... | MODIFY | Summary: Rolled binds the DNA-binding transcription factor Capicua through a MAPK docking site. Reason: The generic protein-binding row should be replaced by DNA-binding transcription factor binding because the cited experiment shows direct interaction between Rolled and the transcriptional repressor Capicua. Proposed replacements: DNA-binding transcription factor binding Supporting Evidence: PMID:17255944 depend on a MAPK docking site in Capicua that physically interacts with the MAPK Rolled |
| GO:0005515 protein binding | IPI PMID:20802461 Ξ²-arrestin Kurtz inhibits MAPK and Toll signalling in Drosop... | MODIFY | Summary: The human beta-arrestin interaction is better captured as arrestin-family protein binding. Reason: The IPI partner is beta-arrestin 2, and the same study analyzes arrestin-dependent ERK sequestration. A specific arrestin-family binding term is more informative than bare protein binding. Proposed replacements: arrestin family protein binding Supporting Evidence: PMID:20802461 Krz can directly bind and sequester an inactive form of ERK |
| GO:0005515 protein binding | IPI PMID:20802461 Ξ²-arrestin Kurtz inhibits MAPK and Toll signalling in Drosop... | MODIFY | Summary: The Kurtz interaction is better captured as arrestin-family protein binding. Reason: Kurtz is the Drosophila beta-arrestin that directly binds inactive ERK/Rolled, so GO:1990763 is the specific MF term supported by the IPI evidence. Proposed replacements: arrestin family protein binding Supporting Evidence: PMID:20802461 Krz can directly bind and sequester an inactive form of ERK |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP binding is an expected molecular-function component of the Rolled kinase domain. Reason: MAP kinases use ATP as the phosphodonor for serine/threonine phosphorylation; the InterPro kinase-domain mapping is consistent with the reviewed UniProt catalytic annotation. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:11782402 MASK, a large ankyrin repeat and KH domain-containing protei... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:12963110 Species-specific activation of EGF receptor signaling underl... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:1378625 Primary structure, expression, and signal-dependent tyrosine... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. Supporting Evidence: PMID:1378625 signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase |
| GO:0005634 nucleus | IDA PMID:16308331 MAP kinase subcellular localization controls both pattern an... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. Supporting Evidence: PMID:16308331 MAP kinase subcellular localization controls both pattern and proliferation |
| GO:0005634 nucleus | IDA PMID:16763554 Inhibition of ERK-MAP kinase signaling by RSK during Drosoph... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:18571412 Nuclear trapping shapes the terminal gradient in the Drosoph... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:23827710 The nuclear lamina regulates germline stem cell niche organi... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. Supporting Evidence: PMID:23827710 Lamin promotes nuclear retention of phosphorylated ERK in the CySC lineage |
| GO:0005634 nucleus | IDA PMID:24046358 Fragile X mental retardation protein regulates trans-synapti... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:24348264 Tay bridge is a negative regulator of EGFR signalling and in... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IDA PMID:9729495 Dissecting the roles of the Drosophila EGF receptor in eye d... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:11782402 MASK, a large ankyrin repeat and KH domain-containing protei... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:1378625 Primary structure, expression, and signal-dependent tyrosine... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:16308331 MAP kinase subcellular localization controls both pattern an... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:16763554 Inhibition of ERK-MAP kinase signaling by RSK during Drosoph... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:17438281 Chimaerin and Rac regulate cell number, adherens junctions, ... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:18571412 Nuclear trapping shapes the terminal gradient in the Drosoph... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:23827710 The nuclear lamina regulates germline stem cell niche organi... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. Supporting Evidence: PMID:23827710 Lamin promotes nuclear retention of phosphorylated ERK in the CySC lineage |
| GO:0005829 cytosol | IDA PMID:24348264 Tay bridge is a negative regulator of EGFR signalling and in... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0005829 cytosol | IDA PMID:9729495 Dissecting the roles of the Drosophila EGF receptor in eye d... | ACCEPT | Summary: Rolled is detected or inferred in both nuclear and cytoplasmic signaling pools. Reason: Rolled is activated in the cytoplasm and can translocate to the nucleus to phosphorylate nuclear transcription-factor substrates; the UniProt record, PAINT propagation, and multiple Drosophila studies support both compartments. |
| GO:0007166 cell surface receptor signaling pathway | IBA GO_REF:0000033 | MODIFY | Summary: The PAINT cell-surface-receptor BP transfer is biologically correct but too broad for Rolled. Reason: The ancestral node captures the conserved ERK cassette downstream of receptor tyrosine kinases, but GO:0070371 ERK1 and ERK2 cascade is the informative process for an ERK MAP kinase. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN008603019 SUPPORTS TRANSFER The PAINT node supports the conserved ERK cassette downstream of cell-surface RTKs, but the parent cell-surface-receptor term is less informative than ERK1 and ERK2 cascade for an ERK MAP kinase. Proposed replacements: ERK1 and ERK2 cascade |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:12169631 Keren, a new ligand of the Drosophila epidermal growth facto... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:29983336 A Switch-like Activation Relay of EGFR-ERK Signaling Regulat... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:7601354 Secreted Spitz triggers the DER signaling pathway and is a l... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:8798773 Biochemical characterization of rolledSem, an activated form... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:9531530 EGF domain swap converts a drosophila EGF receptor activator... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:9806926 Regulation of EGF receptor signaling establishes pattern acr... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IEP PMID:9729495 Dissecting the roles of the Drosophila EGF receptor in eye d... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IGI PMID:24348264 Tay bridge is a negative regulator of EGFR signalling and in... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IGI PMID:8124723 A gain-of-function mutation in Drosophila MAP kinase activat... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IMP PMID:11245584 Role of the EGFR/Ras/Raf pathway in specification of photore... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IMP PMID:8162856 The sevenless signalling cassette mediates Drosophila EGF re... | KEEP AS NON CORE | Summary: Rolled acts in EGFR signaling as the downstream ERK MAP kinase. Reason: Rolled executes the terminal MAPK step downstream of Spitz/Egfr, and the local spi-Egfr GO-CAM models rl as the cytosolic GO:0004707 activity in GO:0007173. This pathway use is well supported but context-specific relative to the core MAP kinase activity. |
| GO:0007362 terminal region determination | IEP PMID:9882506 Quantitative variations in the level of MAPK activity contro... | KEEP AS NON CORE | Summary: Rolled is deployed downstream of Torso during terminal region determination. Reason: Terminal patterning is a developmental output of Torso-dependent ERK signaling, so the annotation is retained as a specific non-core role. |
| GO:0007430 terminal branching, open tracheal system | IMP PMID:25061859 Slik and the receptor tyrosine kinase Breathless mediate loc... | KEEP AS NON CORE | Summary: Rolled contributes to FGF-dependent tracheal terminal branching. Reason: This tracheal phenotype is a tissue-specific deployment of RTK-to-ERK signaling and is retained as non-core developmental biology. |
| GO:0007465 R7 cell fate commitment | IGI PMID:8722784 A screen for genes that function downstream of Ras1 during D... | KEEP AS NON CORE | Summary: Rolled acts downstream of Sevenless during R7 cell fate commitment. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0007474 imaginal disc-derived wing vein specification | IGI PMID:24348264 Tay bridge is a negative regulator of EGFR signalling and in... | KEEP AS NON CORE | Summary: Rolled contributes to ERK-dependent wing vein specification. Reason: Wing vein specification is a well supported developmental output of EGFR/ERK signaling, including Step-dependent MAPK activation, but it is not the core biochemical function of the kinase. |
| GO:0007474 imaginal disc-derived wing vein specification | IMP PMID:15704110 Conserved cross-interactions in Drosophila and Xenopus betwe... | KEEP AS NON CORE | Summary: Rolled contributes to ERK-dependent wing vein specification. Reason: Wing vein specification is a well supported developmental output of EGFR/ERK signaling, including Step-dependent MAPK activation, but it is not the core biochemical function of the kinase. |
| GO:0007474 imaginal disc-derived wing vein specification | IMP PMID:23549788 The Drosophila Arf GEF Steppke controls MAPK activation in E... | KEEP AS NON CORE | Summary: Rolled contributes to ERK-dependent wing vein specification. Reason: Wing vein specification is a well supported developmental output of EGFR/ERK signaling, including Step-dependent MAPK activation, but it is not the core biochemical function of the kinase. |
| GO:0007476 imaginal disc-derived wing morphogenesis | IMP PMID:16308331 MAP kinase subcellular localization controls both pattern an... | KEEP AS NON CORE | Summary: Rolled localization and activity influence wing morphogenesis. Reason: The morphogenetic wing phenotype reflects context-specific control of ERK localization and output in developing wing discs. |
| GO:0007479 leg disc proximal/distal pattern formation | IEP PMID:15965980 Dynamic EGFR-Ras signalling in Drosophila leg development. | KEEP AS NON CORE | Summary: Rolled is used in leg disc proximal-distal patterning downstream of receptor signaling. Reason: This is a developmental deployment of the shared ERK module rather than a separate core activity. |
| GO:0007552 metamorphosis | IMP PMID:19965758 The insect neuropeptide PTTH activates receptor tyrosine kin... | KEEP AS NON CORE | Summary: Rolled acts downstream of PTTH/Torso to promote metamorphosis. Reason: PTTH/Torso signaling uses Rolled/ERK in the prothoracic gland to time ecdysone production and pupariation; this is a hormone/developmental pathway use of the core MAP kinase. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:19141677 EGFR signaling regulates the proliferation of Drosophila adu... | KEEP AS NON CORE | Summary: Rolled-dependent receptor signaling can promote cell proliferation. Reason: Cell proliferation is an output of Ras/ERK signaling in specific tissues, retained here as non-core to the kinase activity itself. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:10823906 Use of double-stranded RNA interference in Drosophila cell l... | KEEP AS NON CORE | Summary: Rolled is phosphorylated and activated downstream of insulin signaling. Reason: The insulin pathway row captures one upstream receptor context in which ERK-A is activated; it is retained as non-core. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:15337530 Drosophila PI3 kinase and Akt involved in insulin-stimulated... | KEEP AS NON CORE | Summary: Rolled is phosphorylated and activated downstream of insulin signaling. Reason: The insulin pathway row captures one upstream receptor context in which ERK-A is activated; it is retained as non-core. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:23980175 ERK signaling couples nutrient status to antiviral defense i... | UNDECIDED | Summary: The cached abstract links ERK to antiviral and nutrient signaling but does not expose the insulin-receptor evidence. Reason: Because the full Rolled/insulin assay is not visible in the cached material, the row should be left for curator follow-up rather than accepted or removed. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:26119340 The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longe... | KEEP AS NON CORE | Summary: Rolled is implicated in insulin-dependent growth and lifespan signaling. Reason: This is a receptor-specific deployment of ERK signaling in nutritional/lifespan physiology, not a distinct core function. |
| GO:0008293 torso signaling pathway | IEP PMID:28166211 Divergent effects of intrinsically active MEK variants on de... | KEEP AS NON CORE | Summary: Rolled acts as the ERK effector in Torso signaling. Reason: Rolled is the ERK effector downstream of the Torso RTK; the local Torso GO-CAM includes rl as the GO:0004707 kinase. The term is a receptor-specific deployment of the same MAPK module and is therefore retained as non-core. |
| GO:0008293 torso signaling pathway | IEP PMID:9882506 Quantitative variations in the level of MAPK activity contro... | KEEP AS NON CORE | Summary: Rolled acts as the ERK effector in Torso signaling. Reason: Rolled is the ERK effector downstream of the Torso RTK; the local Torso GO-CAM includes rl as the GO:0004707 kinase. The term is a receptor-specific deployment of the same MAPK module and is therefore retained as non-core. |
| GO:0008293 torso signaling pathway | IGI PMID:10511556 Genetic analysis of rolled, which encodes a Drosophila mitog... | KEEP AS NON CORE | Summary: Rolled acts as the ERK effector in Torso signaling. Reason: Rolled is the ERK effector downstream of the Torso RTK; the local Torso GO-CAM includes rl as the GO:0004707 kinase. The term is a receptor-specific deployment of the same MAPK module and is therefore retained as non-core. |
| GO:0008293 torso signaling pathway | IGI PMID:8124723 A gain-of-function mutation in Drosophila MAP kinase activat... | KEEP AS NON CORE | Summary: Rolled acts as the ERK effector in Torso signaling. Reason: Rolled is the ERK effector downstream of the Torso RTK; the local Torso GO-CAM includes rl as the GO:0004707 kinase. The term is a receptor-specific deployment of the same MAPK module and is therefore retained as non-core. |
| GO:0008340 determination of adult lifespan | IMP PMID:26119340 The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longe... | KEEP AS NON CORE | Summary: Rolled contributes to adult lifespan phenotypes through nutritional/insulin pathway signaling. Reason: Adult lifespan is a distal physiological output of ERK pathway perturbation and should be kept as non-core. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:10224263 stumps, a Drosophila gene required for fibroblast growth fac... | UNDECIDED | Summary: The cached Stumps/FGF abstract does not expose a Rolled-specific ERK assay. Reason: The paper is abstract-only in the local cache and focuses on Stumps in FGF-guided migration, so the Rolled assertion cannot be verified without the full text. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:12175485 Ligand-dependent activation of breathless FGF receptor gene ... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:15082772 Downstream-of-FGFR is a fibroblast growth factor-specific sc... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:20154139 A novel conserved phosphotyrosine motif in the Drosophila fi... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:30328809 Feedback regulation of cytoneme-mediated transport shapes a ... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IMP PMID:12194851 FGF is an essential mitogen and chemoattractant for the air ... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IMP PMID:15084280 FGF8-like1 and FGF8-like2 encode putative ligands of the FGF... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IMP PMID:25061859 Slik and the receptor tyrosine kinase Breathless mediate loc... | KEEP AS NON CORE | Summary: Rolled is used downstream of FGF receptors in developmental migration and branching programs. Reason: Drosophila FGF receptors feed into the canonical ERK cassette during mesodermal and tracheal migration programs. This is a legitimate developmental use of Rolled but not its core catalytic annotation. |
| GO:0009267 cellular response to starvation | IMP PMID:18794330 Effector caspase Dcp-1 and IAP protein Bruce regulate starva... | KEEP AS NON CORE | Summary: Rolled signaling participates in starvation responses through nutrient signaling crosstalk. Reason: The starvation row reflects a nutritional context of ERK signaling rather than the enzyme's core function. |
| GO:0016242 negative regulation of macroautophagy | IMP PMID:18794330 Effector caspase Dcp-1 and IAP protein Bruce regulate starva... | KEEP AS NON CORE | Summary: Rolled contributes to nutrient-dependent repression of macroautophagy. Reason: The autophagy phenotype is downstream of starvation/nutrient signaling crosstalk and is retained as non-core. |
| GO:0019901 protein kinase binding | IPI PMID:15487973 The Drosophila protein kinase LK6 is regulated by ERK and ph... | ACCEPT | Summary: Rolled binds the protein kinase LK6. Reason: LK6 is a MAPK-interacting kinase regulated by Rolled/ERK, so this specific protein kinase binding annotation is informative and supported. Supporting Evidence: PMID:15487973 LK6 binds ERK |
| GO:0031594 neuromuscular junction | IDA PMID:24046358 Fragile X mental retardation protein regulates trans-synapti... | KEEP AS NON CORE | Summary: Rolled activity is detected at the neuromuscular junction in trans-synaptic signaling studies. Reason: The neuromuscular-junction localization is a specialized neuronal context for ERK signaling and is retained as non-core. |
| GO:0034614 cellular response to reactive oxygen species | IDA PMID:16451733 D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, ... | KEEP AS NON CORE | Summary: Cadmium and arsenite activate Rolled/D-ERK through ROS-dependent oxidative stress in S2 cells. Reason: PMID:16451733 directly shows cadmium- and arsenite-induced, NAC-sensitive D-ERK phosphorylation. The paper's pathway dissection focuses on D-JNK rather than the ERK arm, so this is retained as a stress-specific non-core Rolled deployment rather than removed. Supporting Evidence: PMID:16451733 NAC abolished the ability of both cadmium and arsenite to trigger the phoshorylation of D-JNK, D-p38 MAPK, and D-ERK |
| GO:0035169 lymph gland plasmatocyte differentiation | IMP PMID:23603494 Extracellular matrix-modulated Heartless signaling in Drosop... | KEEP AS NON CORE | Summary: Rolled participates in Ras/ERK control of hematopoietic differentiation. Reason: The lymph-gland annotations are developmental/lineage-specific outcomes of RTK-to-ERK signaling and are retained as non-core. |
| GO:0035170 lymph gland crystal cell differentiation | IMP PMID:23603494 Extracellular matrix-modulated Heartless signaling in Drosop... | KEEP AS NON CORE | Summary: Rolled participates in Ras/ERK control of hematopoietic differentiation. Reason: The lymph-gland annotations are developmental/lineage-specific outcomes of RTK-to-ERK signaling and are retained as non-core. |
| GO:0035202 tracheal pit formation in open tracheal system | IEP PMID:29983336 A Switch-like Activation Relay of EGFR-ERK Signaling Regulat... | KEEP AS NON CORE | Summary: Rolled is deployed in tracheal placode patterning downstream of EGFR. Reason: Tracheal pit formation is a developmental output of the shared ERK cassette. |
| GO:0035556 intracellular signal transduction | IBA GO_REF:0000033 | MODIFY | Summary: The PAINT intracellular-signal-transduction term is a true but overly broad parent for an ERK MAP kinase. Reason: GO:0070371 ERK1 and ERK2 cascade captures the signal-transduction process executed by Rolled more specifically than generic intracellular signal transduction. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN000622075 SUPPORTS TRANSFER PAINT supports intracellular signaling by the conserved MAPK family, but ERK1 and ERK2 cascade is the informative process term for rolled. Proposed replacements: ERK1 and ERK2 cascade |
| GO:0045500 sevenless signaling pathway | IDA PMID:17609117 Boss/Sev signaling from germline to soma restricts germline-... | KEEP AS NON CORE | Summary: Rolled is the MAP kinase in the Sevenless pathway. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0045500 sevenless signaling pathway | IEP PMID:9729495 Dissecting the roles of the Drosophila EGF receptor in eye d... | KEEP AS NON CORE | Summary: Rolled is the MAP kinase in the Sevenless pathway. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0045500 sevenless signaling pathway | IGI PMID:8157002 The Drosophila rolled locus encodes a MAP kinase required in... | KEEP AS NON CORE | Summary: Rolled is the MAP kinase in the Sevenless pathway. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0045500 sevenless signaling pathway | IGI PMID:8722784 A screen for genes that function downstream of Ras1 during D... | KEEP AS NON CORE | Summary: Rolled is the MAP kinase in the Sevenless pathway. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0045500 sevenless signaling pathway | IMP PMID:8124723 A gain-of-function mutation in Drosophila MAP kinase activat... | KEEP AS NON CORE | Summary: Rolled is the MAP kinase in the Sevenless pathway. Reason: The Sevenless pathway is one of the classic Drosophila RTK pathways in which Ras/Raf/Dsor1 activates Rolled during R7 photoreceptor specification. This is sound but context-specific. |
| GO:0045793 positive regulation of cell size | IMP PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. | KEEP AS NON CORE | Summary: Rolled/Pvr signaling promotes hemocyte size control. Reason: Positive regulation of cell size is a context-specific output of Pvr/ERK signaling and is retained as non-core. |
| GO:0046534 positive regulation of photoreceptor cell differentiation | IMP PMID:16763554 Inhibition of ERK-MAP kinase signaling by RSK during Drosoph... | KEEP AS NON CORE | Summary: Rolled/RSK signaling promotes photoreceptor differentiation. Reason: Photoreceptor differentiation is a developmental output of ERK signaling in the eye rather than a primary biochemical function. |
| GO:0046843 dorsal appendage formation | IEP PMID:12963110 Species-specific activation of EGF receptor signaling underl... | KEEP AS NON CORE | Summary: Rolled acts in EGFR-dependent dorsal appendage patterning. Reason: The oogenesis row reflects a spatially restricted EGFR/ERK developmental output and is kept as non-core. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:11595182 Guidance of cell migration by the Drosophila PDGF/VEGF recep... | UNDECIDED | Summary: The cached Pvr paper does not expose a direct Rolled/ERK assignment for this PVR signaling row. Reason: Because the local evidence for this Pvr/VEGFR annotation does not show the Rolled-specific assay, the row should remain for follow-up rather than be removed from incomplete abstract evidence. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:11955438 Developmental control of blood cell migration by the Drosoph... | UNDECIDED | Summary: The cached Pvr paper does not expose a direct Rolled/ERK assignment for this PVR signaling row. Reason: Because the local evidence for this Pvr/VEGFR annotation does not show the Rolled-specific assay, the row should remain for follow-up rather than be removed from incomplete abstract evidence. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:15457211 PVR plays a critical role via JNK activation in thorax closu... | UNDECIDED | Summary: The cached Pvr paper does not expose a direct Rolled/ERK assignment for this PVR signaling row. Reason: Because the local evidence for this Pvr/VEGFR annotation does not show the Rolled-specific assay, the row should remain for follow-up rather than be removed from incomplete abstract evidence. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:18000865 Gliatrophic and gliatropic roles of PVF/PVR signaling during... | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:23878397 Platelet-derived growth factor/vascular endothelial growth f... | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:25130174 Switching between humoral and cellular immune responses in D... | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:30639055 Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting ... | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IMP PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IMP PMID:25749252 A systems-level interrogation identifies regulators of Droso... | KEEP AS NON CORE | Summary: Rolled acts in the Ras/ERK cassette downstream of Pvr/PDGF-VEGF receptor signaling. Reason: Pvr uses the Ras/ERK cassette in hemocyte, thorax-closure, and border-cell contexts. These rows capture receptor-specific deployments of Rolled rather than a distinct core activity. |
| GO:0048149 behavioral response to ethanol | IMP PMID:19464045 Happyhour, a Ste20 family kinase, implicates EGFR signaling ... | KEEP AS NON CORE | Summary: Rolled contributes to ethanol-response behavior through a neuronal ERK pathway. Reason: The behavioral response is a specialized output of ERK signaling and is retained as non-core. |
| GO:0050804 modulation of chemical synaptic transmission | IMP PMID:19144852 Unc-51 controls active zone density and protein composition ... | KEEP AS NON CORE | Summary: Rolled modulates synaptic signaling in a neuronal context. Reason: Chemical-synaptic-transmission modulation is a tissue-specific consequence of ERK pathway activity, not the core kinase activity itself. |
| GO:0051607 defense response to virus | IMP PMID:23980175 ERK signaling couples nutrient status to antiviral defense i... | KEEP AS NON CORE | Summary: Rolled/ERK signaling participates in antiviral defense under nutritional regulation. Reason: The antiviral row captures a stress/nutrient pathway deployment of ERK and is retained as non-core. |
| GO:0060446 branching involved in open tracheal system development | IDA PMID:30328809 Feedback regulation of cytoneme-mediated transport shapes a ... | KEEP AS NON CORE | Summary: Rolled acts in FGF-dependent tracheal branching. Reason: Open-tracheal-system branching is a developmental FGF/ERK output and is non-core relative to MAP kinase activity. |
| GO:0070371 ERK1 and ERK2 cascade | HGI PMID:24643257 A functional screen reveals an extensive layer of transcript... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. |
| GO:0070371 ERK1 and ERK2 cascade | IDA PMID:11850406 KSR is a scaffold required for activation of the ERK/MAPK mo... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. Supporting Evidence: PMID:11850406 KSR functions upstream of MEK within the ERK/MAPK module |
| GO:0070371 ERK1 and ERK2 cascade | IDA PMID:16600912 A KSR/CNK complex mediated by HYP, a novel SAM domain-contai... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. |
| GO:0070371 ERK1 and ERK2 cascade | IDA PMID:8798773 Biochemical characterization of rolledSem, an activated form... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. |
| GO:0070371 ERK1 and ERK2 cascade | IGI PMID:10823906 Use of double-stranded RNA interference in Drosophila cell l... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. |
| GO:0070371 ERK1 and ERK2 cascade | IGI PMID:28166211 Divergent effects of intrinsically active MEK variants on de... | ACCEPT | Summary: The annotation captures Rolled in the conserved ERK cascade. Reason: GO:0070371 is the appropriate process term for the Drosophila Ras/Raf/Dsor1/Rolled cassette downstream of multiple receptor inputs. |
| GO:0071243 cellular response to arsenic-containing substance | IDA PMID:16451733 D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, ... | KEEP AS NON CORE | Summary: Arsenite activates Rolled/D-ERK in the Drosophila S2 oxidative-stress response. Reason: Arsenite triggers D-ERK phosphorylation as part of an oxidative-stress MAP kinase response in S2 cells. This is a peripheral stress deployment of Rolled and should be retained as non-core rather than removed. Supporting Evidence: PMID:16451733 both cadmium and arsenite triggered the phosphorylation of D-JNK, D-p38 MAPK, and D-ERK in a dose- and time-dependent manner. |
| GO:0071276 cellular response to cadmium ion | IDA PMID:16451733 D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, ... | KEEP AS NON CORE | Summary: Cadmium activates Rolled/D-ERK in the Drosophila S2 oxidative-stress response. Reason: Cadmium triggers D-ERK phosphorylation as part of an oxidative-stress MAP kinase response in S2 cells. This is a peripheral stress deployment of Rolled and should be retained as non-core rather than removed. Supporting Evidence: PMID:16451733 both cadmium and arsenite triggered the phosphorylation of D-JNK, D-p38 MAPK, and D-ERK in a dose- and time-dependent manner. |
| GO:0090303 positive regulation of wound healing | IMP PMID:22140578 Hole-in-one mutant phenotypes link EGFR/ERK signaling to epi... | KEEP AS NON CORE | Summary: Rolled is required for embryonic epithelial wound repair downstream of Hole-in-one/EGFR signaling. Reason: Wound healing is a specific developmental/tissue repair output of EGFR/ERK signaling, not a distinct core kinase activity. |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | MODIFY | Summary: The Rhea serine-phosphorylation mapping is correct but too general for a dual-specificity ERK MAP kinase. Reason: Rolled/ERK-A is the Drosophila ERK MAP kinase and is repeatedly assayed or modeled as the GO:0004707 kinase in receptor-tyrosine-kinase MAPK signaling. The broad kinase parent is correct but should be replaced by the specific MAP kinase activity term. Proposed replacements: MAP kinase activity |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:17255944 A MAPK docking site is critical for downregulation of Capicu... | ACCEPT | Summary: Rolled directly binds the Capicua DNA-binding transcription factor. Reason: Capicua is a direct nuclear target of Torso and EGFR signaling and physically interacts with Rolled through its MAPK docking site, so the specific transcription-factor-binding row is supported. Supporting Evidence: PMID:17255944 depend on a MAPK docking site in Capicua that physically interacts with the MAPK Rolled |
| GO:2000826 regulation of heart morphogenesis | IGI PMID:25650441 Cardiac hypertrophy induced by active Raf depends on Yorkie-... | KEEP AS NON CORE | Summary: Rolled genetically modulates heart morphogenesis. Reason: Heart morphogenesis is a tissue-specific developmental output and is retained as non-core. |
| GO:2001023 regulation of response to drug | IMP PMID:22678283 Chemical genetic discovery of targets and anti-targets for c... | KEEP AS NON CORE | Summary: Reducing rolled dosage suppresses drug-dependent dRet wing phenotypes. Reason: The chemical-genetic screen explicitly used the Drosophila erk orthologue rolled as an ERK/Ras pathway modifier of dRet-driven phenotypes and drug response; this is a pharmacologic pathway context rather than a core function. Supporting Evidence: PMID:22678283 Reducing gene dosage of the erk orthologue rolled suppressed these phenotypes |
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Download this section (compressed HTML)rolled (rl) encodes the mitogen activated protein (MAP) kinase, core component of the RAS/MAPK pathway. It is inactivated by the phosphatases encoded by PTP-ER and Mkp3. It phosphorylates a diverse set of downstream cytoplasmic and nuclear effectors, which impact cell fate decisions in a wide array of tissues.
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