Source: https://flybase.org/reports/FBgn0265974
Retrieved 2026-09-08
FlyBase Gene Report: Dmel\ttv Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Sign In Tools Tools Overview & Help Query by symbols/IDs Batch Download Sequence Downloader ID Validator Feature Mapper Search/Browse Portals QuickSearch Vocabularies QueryBuilder CytoSearch Sequenced Species Interactions Browser ImageBrowse Genomics Tools BLAST Fly BLAST @ Alliance JBrowse CytoSearch Feature Mapper Chromosome Maps Synteny Table Coordinates Converter Sequence Downloader modENCODE RNA-Seq Overview RNA-Seq Similarity RNA-Seq Profile RNA-Seq By Region JBrowse Submit Data Fast-Track Your Paper Submit Personal Communication Feedback on Gene Snapshots Downloads Overview Current Release Archived Data Map Conversion Releases (FTP) Links External Resources Model Organisms (MODs) Alliance of Genome Resources BeeBase DictyBase EcoCyc Gramene MGI PomBase Pseudobase RGD SGD TAIR VectorBase WormBase Xenbase ZFIN Stock Collections Bloomington Drosophila Stock Center (BDSC) FlyORF Korea Drosophila Resource Center (KDRC) Kyoto Stock Center NIG-FLY Tsinghua Fly Center (THFC) Vienna Drosophila Resource Center (VDRC) BDGP DGRC DRSC/TRiP DIS by issue FlyBook FlyExpress Interactive Fly Virtual Fly Brain FlyCyc Community Fast-Track Your Paper FlyBase Community Advisory Group Fly Lab List Recent Papers With Technical Advances Gene Snapshots FlyBase Forum Newsletter FlySlack Community Mastodon Bluesky X (formerly Twitter) Fly Board NIH Funding About Release Notes New In This Release Release Schedule FlyBase Positions Citing FlyBase FlyBase Licensing FlyBase Consortium FlyBase Publications FlyBase Presentations Grants Supporting FlyBase Help Contact FlyBase FlyBase Wiki: Help Index Tool help Report help FlyBase FAQ Info for Authors Author guidelines Citing FlyBase Fast-Track Your Paper Help Gene Snapshots Personal communications Linking to/from FlyBase Nomenclature Curation documentation Controlled Vocabularies in FlyBase Gene Model Annotation Gene Ontology (GO) Annotation Nontraditional alleles Vectors & Constructs New to Flies? Video Tutorials Programmatic Access to FlyBase: APIs, etc. Developmental Dysregulation and Cancer Kathy Matthews BDSC Endowment Using AI to get FlyBase data FlyBase in AWS Open Data Previous Next FB2026_02 , released June 18, 2026 Gene: Dmel\ttv J2G Search Go Open Close General Information Symbol Dmel\ ttv Species D. melanogaster Name tout-velu Annotation Symbol CG10117 Feature Type protein_coding_gene FlyBase ID FBgn0265974 Gene Model Status Current Stock Availability 29 publicly available Enzyme Name (EC) glucuronosyltransferase
            ( 2.4.1.17 ) glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase
            ( 2.4.1.224 ) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
            ( 2.4.1.225 ) Gene Summary tout-velu ( ttv ) encodes a glycosyltransferase that forms a complex with sotv to catalyze the alternating transfer of glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc) to their respective acceptors, GlcNAc and GlcA, during the elongation of the heparan sulfate glycosaminoglycan chain.

          [Date last reviewed: 2024-12-19]
        
              ( FlyBase Gene Snapshot ) All Summaries Gene Snapshot Alliance Auto summary Gene Group UniProtKB Interactive Fly Also Known As l(2)05282, DEXT1, l(2)k03617, l(2)00681, EXT1 Key Links Genomic Location Cytogenetic map 51A7-51B4 Sequence location 2R:14,526,267..14,587,917 [+] Recombination map (full details) 2-72 RefSeq locus NT_033778 REGION: 14526267..14587917 Sequence Gene region Extended Gene region CDS Introns Exons Transcripts Translations 5' UTR 3' UTR Get Sequence Get Decorated FASTA Genomic Maps JBrowse Other Genome Views The following external sites may use different assemblies or annotations than FlyBase. NCBI UCSC Ensembl PopFly Function Gene Ontology (GO) Annotations (14 terms) Molecular Function (6 terms) Terms Based on Experimental Evidence (3 terms) CV Term Evidence References enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity inferred from direct assay ( Izumikawa et al.,  2006 ) enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity inferred from direct assay ( Izumikawa et al.,  2006 ) enables protein binding inferred from physical interaction with UniProtKB:Q9Y169 ( Izumikawa et al.,  2006 ) Terms Based on Predictions or Assertions (3 terms) CV Term Evidence References enables acetylglucosaminyltransferase activity inferred from biological aspect of ancestor with PANTHER:PTN000869020 ( GO Reference Genome Project,  2011- ) enables glucuronosyltransferase activity inferred from biological aspect of ancestor with PANTHER:PTN000869020 ( GO Reference Genome Project,  2011- ) enables glycosyltransferase activity inferred from electronic annotation with InterPro:IPR004263 , InterPro:IPR015338 ( InterPro Project Members,  2004- ) Biological Process (4 terms) Terms Based on Experimental Evidence (3 terms) CV Term Evidence References involved_in germ cell migration inferred from mutant phenotype ( Deshpande et al.,  2007 ) involved_in glycosaminoglycan biosynthetic process inferred from mutant phenotype ( Toyoda et al.,  2000 , Toyoda et al.,  2000 ) involved_in heparan sulfate proteoglycan biosynthetic process inferred from mutant phenotype ( Ren et al.,  2009 , Bornemann et al.,  2004 , Han et al.,  2004 , Kim et al.,  2002 ) inferred from mutant phenotype ( Takei et al.,  2004 , The et al.,  1999 ) inferred from direct assay ( Izumikawa et al.,  2006 ) NOT involved_in germ cell migration inferred from mutant phenotype ( Renault et al.,  2009 ) Terms Based on Predictions or Assertions (2 terms) CV Term Evidence References involved_in glycoprotein biosynthetic process inferred from electronic annotation with InterPro:IPR004263 ( InterPro Project Members,  2004- ) involved_in heparan sulfate proteoglycan biosynthetic process inferred from sequence or structural similarity with UniProtKB:O77783 ( Gene Ontology Curators,  2002- ) Cellular Component (4 terms) Terms Based on Experimental Evidence (3 terms) CV Term Evidence References located_in endoplasmic reticulum inferred from direct assay ( Han et al.,  2004 , The et al.,  1999 ) part_of EXT1-EXT2 complex inferred from direct assay ( Han et al.,  2004 ) located_in Golgi apparatus inferred from direct assay ( Han et al.,  2004 , The et al.,  1999 ) Terms Based on Predictions or Assertions (2 terms) CV Term Evidence References is_active_in Golgi apparatus inferred from biological aspect of ancestor with PANTHER:PTN000115158 ( GO Reference Genome Project,  2011- ) located_in membrane inferred from electronic annotation with InterPro:IPR015338 ( InterPro Project Members,  2004- ) non-traceable author statement ( Bellaiche et al.,  1998 ) Gene Group (FlyBase) PROTEOGLYCAN N-ACETYLGLUCOSAMINYLTRANSFERASES GLUCURONOSYLTRANSFERASES EXT1-EXT2 COMPLEX Pathway (FlyBase) HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHESIS Protein Family ( UniProt ) Belongs to the glycosyltransferase 47 family.
                    ( Q9V730 ) Protein Signatures ( InterPro ) Exostosin, GT47 domain Exostosin-like Glycosyl transferase 64 domain Nucleotide-diphospho-sugar transferases Catalytic Activity ( EC / Rhea ) glucuronosyltransferase activity glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D- glucuronoside + UDP + H(+)
            ( 2.4.1.17 ) RHEA 21032 : glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D- GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)
            ( 2.4.1.224 ) RHEA 16213 : N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)- beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L- seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA- (1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)
            ( 2.4.1.225 ) RHEA 20908 : Summaries Gene Snapshot tout-velu ( ttv ) encodes a glycosyltransferase that forms a complex with sotv to catalyze the alternating transfer of glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc) to their respective acceptors, GlcNAc and GlcA, during the elongation of the heparan sulfate glycosaminoglycan chain.

          [Date last reviewed: 2024-12-19] Automated Description (Alliance of Genome Resources) (Alliance, FBgn0265974 ) Automatically Generated Summary (FlyBase) Gene Group (FlyBase) PROTEOGLYCAN N-ACETYLGLUCOSAMINYLTRANSFERASES - Proteoglycan N-acetylglucosaminyltransferases catalyze the transfer of N-acetylglucosamine (GlcNAc) to proteoglycans, such as heparan sulfate proteoglycans (HSPGs). HSPGs consist of a protein core to which heparan sulfate (HS) glycosaminoglycan (GAG) chains are attached. The biosynthesis of HS GAG chains is initiated by the formation of a GAG-protein linkage region consisting of a tetrasaccharide attached to specific serine residues in a proteoglycan core protein. Both the attachment of the first GlcNAc to the GAG-protein linkage region and the subsequent polymer formation are catalyzed by members of the hereditary multiple exostoses (EXT) gene family of tumor suppressors, or their orthologs. HSPGs are implicated in regulating the signalling activities of secreted morphogen molecules including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp). (Adapted from FBrf0174560 .) GLUCURONOSYLTRANSFERASES - Glucuronosyltransferases catalyze the conjugation of glucuronic acid from UDP-glucuronate to an acceptor, typically a small lipophilic molecule. (Adapted from PMID:26453144 .) EXT1-EXT2 COMPLEX - The EXT1-EXT2 complex is a heterodimer required for the elongation of heparan sulfate proteoglycan (HSPG) chains. HSPGs are implicated in regulating the signalling activities of secreted morphogen molecules including Wingless, Hedgehog and Decapentaplegic. Each protein monomer within the complex contains distinct glycosyltransferase domains with different activities. (Adapted from PMID:36593275 and FBrf0174560 .) Pathway (FlyBase) HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHESIS - Heparan sulfate proteoglycans (HSPGs) are glycoconjugates that consist of a core protein linked to one or more linear heparan sulfate (HS) chains. The chains are composed of alternating N-acetyl-D-glucosamine and glucuronic acid or iduronic acid that can be variably N- and O-sulfated. HS synthesis occurs in the Golgi apparatus. It starts with the formation of a tetrasaccharide linker on the core protein followed by the alternating addition of glucuronic acid and N-acetylglucosamine residues. Glucuronic acid can undergo epimerization into iduronic acid, which together with N-acetylglucosamine residues, can be sulfated. HSPGs are then transported to the plasma membrane where they can be processed further by endosulfatases such as Sulf1 that remove sulfate groups from specific sites. (Adapted from FBrf0232460 and FBrf0228609 .) Protein Function (UniProtKB) Glycosyltransferase required for the biosynthesis of  heparan-sulfate and responsible for the alternating addition of  beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked  N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate  chains. Botv is the trigger of heparan sulfate chain initiation and  polymerization takes place by a complex of ttv and sotv. Plays a  central role in the diffusion of morphogens hedgehog (hh), wingless  (wg) and decapentaplegic (dpp) via its role in heparan sulfate  proteoglycans (HSPGs) biosynthesis which are required for movement  of hh, dpp and wg morphogens. (UniProt, Q9V730 ) Summary (Interactive Fly) acetylglucosaminyltransferase - involved in heparan sulfate proteoglycan biosynthesis - affects diffusion of Wingless, Hedgehog and Decapentaplegic Interactive Fly Gene Model and Products Number of Transcripts 4 Number of Unique Polypeptides 3 Please see the JBrowse view of Dmel\ ttv for information on other features To submit a correction to a gene model please use the Contact FlyBase form Protein Domains (via Pfam) Isoform displayed: Pfam protein domains InterPro name classification start end Protein Domains (via SMART) Isoform displayed: SMART protein domains InterPro name classification start end Structure Protein 3D structure   (Predicted by AlphaFold )  
                    ( AlphaFold entry Q9V730 ) If you don't see a structure in the viewer, refresh your browser. Model Confidence: Very high (pLDDT > 90) Confident (90 > pLDDT > 70) Low (70 > pLDDT > 50) Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
                          Some regions with low pLDDT may be unstructured in isolation. Experimentally Determined Structures Crossreferences Comments on Gene Model Tissue-specific extension of 3' UTRs observed during later stages ( FBrf0218523 , FBrf0219848 ); all variants may not be annotated Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated. Stop-codon suppression (UAG) postulated; FBrf0234051 . Gene model reviewed during 6.25 Transcript Data Annotated Transcripts Name FlyBase ID RefSeq ID Length (nt) Assoc. CDS (aa) ttv-RA FBtr0087495 NM_057883 3994 760 ttv-RB FBtr0333164 NM_001274042 6899 760 ttv-RC FBtr0333165 NM_001274043 2351 299 ttv-RD FBtr0474168 NM_001369957 3994 772 Additional Transcript Data and Comments Reported size (kB) 3.8 (longest cDNA) ( Bellaiche et al.,  1998 ) Comments External Data Crossreferences Polypeptide Data Annotated Polypeptides Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI UniProt RefSeq ID GenBank ttv-PA FBpp0086624 87.3 760 9.37 Q9V730 NP_477231 AAF58236 ttv-PB FBpp0305367 87.3 760 9.37 Q9V730 NP_001260971 AGB93503 ttv-PC FBpp0305368 34.4 299 9.71 D5SHU8 NP_001260972 AGB93504 ttv-PD FBpp0423167 88.7 772 9.51 QCD26199 Polypeptides with Identical Sequences The group(s) of polypeptides indicated below share identical sequence to each other. 760 aa isoforms: ttv-PA , ttv-PB Additional Polypeptide Data and Comments Reported size (kDa) 760 (aa); 80 (kD observed) ( Bellaiche et al.,  1998 ) Comments External Data Subunit Structure (UniProtKB) Interacts with sau ( PubMed:23720043 ). (UniProt, Q9V730 ) Crossreferences InterPro -
                  A database of protein families, domains and functional sites Exostosin-like Glycosyl transferase 64 domain Nucleotide-diphospho-sugar transferases Exostosin, GT47 domain Linkouts Sequences Consistent with the Gene Model Nucleotide / Polypeptide Records AA141777 AA201422 AA202549 AA203094 AA264876 AA392023 AA392029 AA438478 AA438594 AA538690 AA540291 AE013599 / AAF58236 AB082204 AB221351 / BAE78509 AC008306 AF083889 / AAC32397 AE013599 / AGB93503 AE013599 / AGB93504 AQ025728 AQ026040 AQ026500 BG637129 BG637790 BG637960 BG638166 BH840616 BI142008 BI164768 BI164834 BI170368 BI215274 BI241338 BI368839 BI369106 BI369493 BI373052 BI373943 BI374059 BI484496 BI565751 BI638731 BP551252 BP551253 BT021403 / AAX33551 BT124899 CO276622 CO282348 CO283966 CO284024 CO286247 CO292488 CO321374 CO321403 CO325832 CO338123 CZ467446 CZ468264 CZ468826 CZ470366 CZ474937 CZ479934 CZ479935 CZ481711 CZ485734 EC069981 EC079653 EC197704 EC198462 EC211773 EC222429 EC222555 EC234966 EC258967 EC262518 FE426489 FE426505 FE426569 FE862643 FE863200 GH739718 GH741762 GH742916 GH744455 GH762934 GH779323 GH779635 GH779871 GO254551 AE013599 / QCD26199 UniProt Q9V730 D5SHU8 A0A0B4KER9 A0A4P7VB75 Mapped Features Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping
                        Dmel\ttv
                        using the Feature Mapper tool. Feature Mapper External Data Crossreferences Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. ttv_1 ttv_2 ttv_3 Linkouts Expression Data Testis-specificity index The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al. , 2018 to indicate the degree of testis enrichment compared to other tissues.
                Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias). -0.78 Transcript Expression Additional Descriptive Data Marker for Subcellular Localization CV Term Polypeptide Expression western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage organism ( The et al.,  1999 ) Additional Descriptive Data Epitope-tagged ttv protein colocalizes with Golgi apparatus marker βCop and endoplasmic reticulum marker Bip , but not with plasma membrane markers Arm or shg , indicating that it is localized to the secretory apparatus, and not to the plasma membrane. ( The et al.,  1999 ) Marker for Subcellular Localization CV Term Evidence References located_in endoplasmic reticulum inferred from direct assay ( Han et al.,  2004 , The et al.,  1999 ) part_of EXT1-EXT2 complex inferred from direct assay ( Han et al.,  2004 ) located_in Golgi apparatus inferred from direct assay ( Han et al.,  2004 , The et al.,  1999 ) Expression Deduced from Reporters High-Throughput Expression Data Associated Tools JBrowse - Visual display of RNA-Seq signals View Dmel\ ttv in JBrowse RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region View exonic expression by developmental stage for Dmel\ ttv View exonic expression by tissue for Dmel\ ttv Bulk Downloads RNA-Seq RPKM values for all genes Reference See Gelbart and Emmert, 2013 for analysis details and data files for all genes. Developmental Proteome: Life Cycle Developmental Proteome: Embryogenesis ttv External Data and Images Linkouts DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 36614/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0265974 FlyAtlas -
                  Adult expression by tissue, using Affymetrix Dros2 array FBgn0020245 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0265974 Fly-FISH -
                  A database of Drosophila embryo and larvae mRNA localization patterns CG10117 Images FlyBase Wiki Image Based Resources Alleles, Insertions, Transgenic Constructs, and Aberrations Classical and Insertion Alleles
            ( 70 ) For All Classical and Insertion Alleles Show Pre-selected data Choose specific data Other relevant insertions Transgenic Constructs
            ( 12 ) For All Alleles Carried on Transgenic Constructs Show Pre-selected data Choose specific data Transgenic constructs containing/affecting coding region of ttv Transgenic constructs containing regulatory region of ttv Aberrations (Deficiencies and Duplications)
              ( 10 ) Inferred from experimentation
                  ( 10 ) Gene disrupted in Df(2R)03072 ( Bischoff et al.,  2009 , Spradling et al.,  1999 , BDGP Project Members,  1994-1999 ) Df(2R)BSC357 ( Patterson et al.,  2025 ) Df(2R)BSC668 ( Christensen et al.,  2008.12.28 ) Df(2R)ED2354 ( Patterson et al.,  2025 ) Df(2R)Exel6284 ( Patterson et al.,  2025 ) Df(2R)Exel8059 ( Patterson et al.,  2025 ) Df(2R)trix ( Schulze et al.,  2005 , Spradling et al.,  1999 , Bellaiche et al.,  1998 , Dickson et al.,  1995 , BDGP Project Members,  1994-1999 ) Gene partially disrupted in Df(2L)LamC EX187 ( Schulze et al.,  2005 ) Df(2L)LamC EX296 ( Schulze et al.,  2005 ) Gene not disrupted in Df(2L)LamC EX187 ( Schulze et al.,  2005 ) Df(2L)LamC EX296 ( Schulze et al.,  2005 ) Df(3R)2-2 ( BDGP Project Members,  1994-1999 ) Inferred from location
                  ( 6 ) Export to HitList Df(2R)BSC357 Df(2R)BSC668 Df(2R)ED2354 Df(2R)Exel6284 Df(2R)Exel8059 Dp(2;3)GV-CH321-64O22 Variants Variant Molecular Consequences Alleles Representing Disease-Implicated Variants Phenotypes For more details about a specific phenotype click on the relevant allele symbol. Lethality Allele lethal , with Scer\GAL4 Act5C.PU ttv RNAi.UAS.cYa ttv RNAi.UAS lethal (with ttv 00681b ) ttv G00158 ttv k11904 ttv NP3088 ttv SH0631 ttv UM-8373-3 lethal (with ttv G00158 ) ttv 00681b lethal (with ttv k11904 ) ttv 00681b lethal (with ttv NP3088 ) ttv 00681b lethal (with ttv SH0631 ) ttv 00681b lethal (with ttv UM-8373-3 ) ttv 00681b lethal | embryonic stage | rescuable maternal effect ttv 00681b lethal | recessive ttv 00681b ttv 01901 ttv k00115 ttv k00812 ttv k01106 ttv k03617 ttv k06619 ttv k11904 ttv SH0631 lethal - all die before end of pupal stage ttv 00681b lethal - all die before end of pupal stage , with Scer\GAL4 da.G32 , ttv 00681b ttv UAS.Tag:MYC lethal - all die before end of pupal stage , with Scer\GAL4 da.G32 , ttv UAS.Tag:MYC ttv 00681b lethal - all die before end of pupal stage , with Scer\GAL4 elav-C155 , ttv 00681b ttv UAS.Tag:MYC lethal - all die before end of pupal stage , with Scer\GAL4 elav-C155 , ttv UAS.Tag:MYC ttv 00681b lethal - all die before end of pupal stage , with Scer\GAL4 G14 , ttv 00681b ttv UAS.Tag:MYC lethal - all die before end of pupal stage , with Scer\GAL4 G14 , ttv UAS.Tag:MYC ttv 00681b lethal - all die before end of pupal stage (with ttv 205 ) ttv 524 lethal - all die before end of pupal stage (with ttv 524 ) ttv 205 lethal - all die during embryonic stage | germline clone | maternal effect ttv 02055 lethal - all die during embryonic stage | rescuable maternal effect ttv 00681b lethal - all die during P-stage ttv 00681b partially lethal - majority die ttv 05282 partially lethal - majority die , with Scer\GAL4 pnr-MD237 ttv GD1993 partially lethal - majority die | recessive ttv 05282 viable , with Dcr-2 UAS.cDa , Scer\GAL4 elav.PLu ttv GD1993 viable , with Scer\GAL4 Mef2.PR ttv GD1993 viable , with Scer\GAL4 tin.CΔ4 ttv GD1993 viable (with ttv 00681b ) ttv EP2199 ttv EX3 ttv EX5 ttv EX16 ttv EX187 ttv EX265 ttv EX296 ttv EX364 viable (with ttv EP2199 ) ttv 00681b viable (with ttv EX3 ) ttv 00681b viable (with ttv EX5 ) ttv 00681b viable (with ttv EX16 ) ttv 00681b viable (with ttv EX187 ) ttv 00681b viable (with ttv EX265 ) ttv 00681b viable (with ttv EX296 ) ttv 00681b viable (with ttv EX364 ) ttv 00681b Other Phenotypes Allele abnormal locomotor behavior | pupal stage ttv 00681b abnormal neuroanatomy ttv 00681b ttv 05282 abnormal neuroanatomy | cell non-autonomous | somatic clone | third instar larval stage ttv 63 abnormal neuroanatomy | cell non-autonomous | somatic clone | third instar larval stage , with Scer\GAL4 Act5C.PI ttv GD1993 abnormal neuroanatomy | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 abnormal neuroanatomy | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR10C12 ttv GD1993 abnormal neuroanatomy | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR16D01 ttv GD1993 abnormal neuroanatomy | cell non-autonomous | third instar larval stage , with Scer\GAL4 hh-Gal4 ttv GD1993 abnormal neurophysiology | pupal stage ttv 00681b increased cell number | adult stage , with Scer\GAL4 esg.PU ttv HMC03225 increased occurrence of cell division | adult stage , with Scer\GAL4 esg.PU ttv HMC03225 long lived | dominant ttv 00681b segment polarity phenotype | germline clone | rescuable maternal effect ttv 02055 some die during embryonic stage | germline clone | maternal effect | maternal effect ttv 02055 some die during pupal stage ttv 00681b some die during pupal stage , with Scer\GAL4 da.G32 , ttv 00681b ttv UAS.Tag:MYC some die during pupal stage , with Scer\GAL4 da.G32 , ttv UAS.Tag:MYC ttv 00681b some die during pupal stage , with Scer\GAL4 elav-C155 , ttv 00681b ttv UAS.Tag:MYC some die during pupal stage , with Scer\GAL4 elav-C155 , ttv UAS.Tag:MYC ttv 00681b some die during pupal stage , with Scer\GAL4 G14 , ttv 00681b ttv UAS.Tag:MYC some die during pupal stage , with Scer\GAL4 G14 , ttv UAS.Tag:MYC ttv 00681b some die during pupal stage , with Scer\GAL4 pnr-MD237 ttv GD1993 some die during pupal stage (with ttv 205 ) ttv 524 some die during pupal stage (with ttv 524 ) ttv 205 visible , with Scer\GAL4 pnr-MD237 ttv GD1993 visible | adult stage , with Scer\GAL4 Mef2.PR ttv GD1993 visible | recessive | somatic clone ttv 00681b wild-type ttv EP2199 ttv EX3 ttv EX5 ttv EX16 ttv EX187 ttv EX265 ttv EX296 ttv EX364 ttv hs.PB Phenotype manifest in Allele adult head , with Scer\GAL4 elav-C155 ttv GD1993 adult midgut epithelium , with Scer\GAL4 esg.PU ttv HMC03225 anterior fascicle & bouton ttv 00681b ttv 05282 bouton ttv 00681b bouton , with Scer\GAL4 da.G32 , ttv 00681b ttv UAS.Tag:MYC bouton , with Scer\GAL4 da.G32 , ttv UAS.Tag:MYC ttv 00681b cuticle ttv 00681b dendritic tree | cell non-autonomous | somatic clone | third instar larval stage , with Scer\GAL4 Act5C.PI ttv GD1993 dendritic tree | cell non-autonomous | third instar larval stage ttv 63 dendritic tree | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 dendritic tree | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR10C12 ttv GD1993 dendritic tree | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR16D01 ttv GD1993 dendritic tree | cell non-autonomous | third instar larval stage , with Scer\GAL4 hh-Gal4 ttv GD1993 denticle | ectopic | germline clone | rescuable maternal effect ttv 02055 denticle | germline clone | maternal effect ttv 00681b distal dendrite | cell non-autonomous | somatic clone | increased number | third instar larval stage , with Scer\GAL4 Act5C.PI ttv GD1993 distal dendrite | cell non-autonomous | third instar larval stage ttv 63 distal dendrite | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR10C12 ttv GD1993 distal dendrite | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR16D01 ttv GD1993 distal dendrite | cell non-autonomous | third instar larval stage , with Scer\GAL4 hh-Gal4 ttv GD1993 embryonic/first instar larval cuticle | germline clone ttv 00681b embryonic/first instar larval cuticle | germline clone | maternal effect ttv 00681b embryonic/first instar larval cuticle | germline clone | rescuable maternal effect ttv 02055 embryonic/larval salivary gland , with Scer\GAL4 fkh.PH ttv EP2199 eye | P-stage (with ttv 205 ) ttv 524 eye | P-stage (with ttv 524 ) ttv 205 eye | somatic clone ttv 00681b germline cell , with Scer\GAL4 elav.PLu ttv UAS.Tag:MYC germline cell , with Scer\GAL4 ptc-559.1 ttv UAS.Tag:MYC germline cell , with Scer\GAL4 wg.PM ttv UAS.Tag:MYC germline cell | non-rescuable maternal effect ttv unspecified imaginal disc | larval stage (with ttv 205 ) ttv 524 imaginal disc | larval stage (with ttv 524 ) ttv 205 larval dorsal multidendritic neuron ddaA | cell non-autonomous | third instar larval stage , with Scer\GAL4 hh-Gal4 ttv GD1993 larval dorsal multidendritic neuron ddaB | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 larval dorsal multidendritic neuron ddaD | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 larval dorsal multidendritic neuron ddaE | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 larval multidendritic class IV neuron | cell non-autonomous | somatic clone | third instar larval stage , with Scer\GAL4 Act5C.PI ttv GD1993 larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage ttv 63 larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage , with Scer\GAL4 A58 ttv GD1993 larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR10C12 ttv GD1993 larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage , with Scer\GAL4 GMR16D01 ttv GD1993 larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage , with Scer\GAL4 hh-Gal4 ttv GD1993 leg | P-stage (with ttv 205 ) ttv 524 leg | P-stage (with ttv 524 ) ttv 205 macrochaeta ttv BG01109 synapse ttv 00681b trichogen cell , with Scer\GAL4 pnr-MD237 ttv GD1993 ventral denticle belt ttv 00681b wing , with Scer\GAL4 Mef2.PR ttv GD1993 wing | somatic clone ttv 63 ttv 205 ttv 524 wing disc ttv 00681b wing disc | larval stage (with ttv 205 ) ttv 524 wing disc | larval stage (with ttv 524 ) ttv 205 wing margin | somatic clone ttv 63 ttv 02055 wing margin bristle | ectopic | somatic clone ttv 02055 wing vein | ectopic , with Scer\GAL4 A9 ttv RNAi.UAS.cYa wing vein | ectopic , with Scer\GAL4 Bx-MS1096 ttv RNAi.UAS.cYa wing vein | ectopic , with Scer\GAL4 sd-SG29.1 ttv RNAi.UAS.cYa wing vein | somatic clone ttv 63 wing vein L3 | somatic clone ttv 02055 wing vein L4 | somatic clone ttv 02055 Orthologs Downloads Download All DIOPT Orthologs Human Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Homo sapiens (Human) (5) Hsap\EXT1 13 of 14 Yes Yes 2 Hsap\EXTL1 8 of 14 No Yes Hsap\EXT2 3 of 14 No No Hsap\EXTL3 3 of 14 No No Hsap\EXTL2 2 of 14 No No Model Organism Orthologs (via DIOPT v9.1) Species\Gene Symbol Score Best Score Best Reverse Score Source Compara Domainoid eggNOG Hieranoid Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Complementation? Transgene? Rattus norvegicus (Norway rat) (5) Rnor\Ext1 13 of 14 Yes Yes Rnor\Extl1 8 of 14 No Yes Rnor\Ext2 3 of 14 No No Rnor\Extl3 3 of 14 No No Rnor\Extl2 2 of 14 No No Mus musculus (laboratory mouse) (5) Mmus\Ext1 13 of 14 Yes Yes Mmus\Extl1 8 of 14 No Yes Mmus\Extl3 3 of 14 No No Mmus\Ext2 2 of 14 No No Mmus\Extl2 2 of 14 No No Xenopus tropicalis (Western clawed frog) (6) Xtro\ext1 11 of 13 Yes Yes Xtro\ext2 2 of 13 No No Xtro\extl3 2 of 13 No No Xtro\extl2 1 of 13 No Yes Xtro\myo7b 1 of 13 No No Xtro\skiv2l 1 of 13 No No Danio rerio (Zebrafish) (10) Drer\ext1b 12 of 14 Yes Yes Drer\ext1a 11 of 14 No Yes Drer\ext1c 11 of 14 No Yes Drer\ext2 3 of 14 No No Drer\extl3 3 of 14 No No Drer\extl2 2 of 14 No Yes Drer\LOC108179064 2 of 14 No Yes Drer\LOC101885478 1 of 14 No Yes Drer\si:dkey-13e3.1 1 of 14 No Yes Drer\si:rp71-23d18.4 1 of 14 No Yes Caenorhabditis elegans (Nematode, roundworm) (2) Cele\rib-1 11 of 14 Yes Yes Cele\rib-2 3 of 14 No No Anopheles gambiae (African malaria mosquito) (3) Agam\AgaP_AGAP010388 12 of 12 Yes Yes Agam\AgaP_AGAP000081 3 of 12 No No Agam\AgaP_AGAP001688 3 of 12 No No Arabidopsis thaliana (thale-cress) (42) Atha\AT3G07620 6 of 13 Yes Yes Atha\AT3G42180 6 of 13 Yes Yes Atha\AT4G16745 6 of 13 Yes Yes Atha\AT4G32790 6 of 13 Yes Yes Atha\AT4G38040 6 of 13 Yes Yes Atha\AT5G03795 6 of 13 Yes Yes Atha\AT5G11130 6 of 13 Yes Yes Atha\AT5G11610 6 of 13 Yes Yes Atha\AT5G19670 6 of 13 Yes Yes Atha\AT5G20260 6 of 13 Yes Yes Atha\AT5G25310 6 of 13 Yes Yes Atha\AT5G25820 6 of 13 Yes Yes Atha\AT5G37000 6 of 13 Yes Yes Atha\XGD1 6 of 13 Yes Yes Atha\F8H 5 of 13 No Yes Atha\FRA8 5 of 13 No Yes Atha\GUT1 5 of 13 No Yes Atha\GUT2 5 of 13 No Yes Atha\EPC1 4 of 13 No No Atha\ARAD1 3 of 13 No Yes Atha\ARAD2 3 of 13 No Yes Atha\AT1G21480 3 of 13 No Yes Atha\AT1G34270 3 of 13 No Yes Atha\AT1G67410 3 of 13 No Yes Atha\AT1G68470 3 of 13 No Yes Atha\AT1G80290 3 of 13 No Yes Atha\AT2G31990 3 of 13 No Yes Atha\AT2G32750 3 of 13 No Yes Atha\AT4G22580 3 of 13 No Yes Atha\AT5G16890 3 of 13 No Yes Atha\AT5G41250 3 of 13 No Yes Atha\MUR3 3 of 13 No Yes Atha\RHS8 3 of 13 No Yes Atha\AT1G74680 2 of 13 No Yes Atha\AT2G29040 2 of 13 No Yes Atha\AT3G45400 2 of 13 No Yes Atha\AT3G57630 2 of 13 No Yes Atha\AT4G13990 2 of 13 No Yes Atha\EDA5 2 of 13 No Yes Atha\GT13 2 of 13 No Yes Atha\GT18 2 of 13 No Yes Atha\AT5G04500 1 of 13 No Yes Saccharomyces cerevisiae (Brewer's yeast) (0) Schizosaccharomyces pombe (Fission yeast) (0) Escherichia coli (enterobacterium) (0) Other Organism Orthologs (via OrthoDB) Data provided directly from OrthoDB:ttv .
              Refer to their site for version information. Paralogs Downloads Download All DIOPT Paralogs Paralogs (via DIOPT v9.1) Gene Symbol Score Source Compara Domainoid eggNOG Homologene Inparanoid OMA OrthoDB OrthoFinder OrthoInspector orthoMCL Panther Phylome SonicParanoid Alignment Drosophila melanogaster (Fruit fly) (2) botv 8 of 13 sotv 8 of 13 Human Disease Associations FlyBase Human Disease Model Reports Disease Ontology (DO) Annotations Models Based on Experimental Evidence ( 1 ) Allele Disease Evidence References ttv RNAi.UAS.cUa model of germ cell cancer CEA ( Levings and Nakato,  2018 ) Potential Models Based on Orthology
            ( 3 ) Human Ortholog Disease Evidence References EXT1; exostosin glycosyltransferase 1 model of chondrosarcoma IEA ( FlyBase,  2019- ) model of hereditary multiple exostoses IEA ( FlyBase,  2019- ) EXT2; exostosin glycosyltransferase 2 model of hereditary multiple exostoses IEA ( FlyBase,  2019- ) Modifiers Based on Experimental Evidence ( 3 ) Allele Disease Interaction References ttv 00681b ameliorates Parkinson's disease 2 modeled by park Δ21 , park 1 ( Reynolds-Peterson et al.,  2020 ) ttv k11904 exacerbates autosomal dominant cerebellar ataxia modeled by Hsap\ATXN8OS CTG112.UAS ( Mutsuddi et al.,  2004 ) ttv GD1993 exacerbates neonatal diabetes mellitus modeled by Hsap\INS C96Y.UAS ( He et al.,  2014 ) exacerbates tauopathy modeled by Hsap\MAPT R406W.UAS ( Butzlaff et al.,  2015 ) ameliorates cancer modeled by Pten KK109278 ( Parniewska and Stocker,  2020 ) ameliorates Alzheimer's disease modeled by Psn 541.UAS ( Reynolds-Peterson et al.,  2020 ) Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM) Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown. Homo sapiens (Human) Gene name Score OMIM OMIM Phenotype DO term Complementation? Transgene? EXT1; exostosin glycosyltransferase 1 13 of 14 608177 CHONDROSARCOMA EXOSTOSES, MULTIPLE, TYPE I; EXT1 chondrosarcoma hereditary multiple exostoses EXTL1; exostosin like glycosyltransferase 1 8 of 14 601738 EXT2; exostosin glycosyltransferase 2 3 of 14 608210 SEIZURES, SCOLIOSIS, AND MACROCEPHALY/MICROCEPHALY SYNDROME; SSMS EXOSTOSES, MULTIPLE, TYPE II; EXT2 hereditary multiple exostoses EXTL3; exostosin like glycosyltransferase 3 3 of 14 605744 IMMUNOSKELETAL DYSPLASIA WITH NEURODEVELOPMENTAL ABNORMALITIES; ISDNA Functional Complementation Data Functional complementation data is computed by FlyBase using a combination of the orthology data
                  obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the
                  literature. Dmel gene Ortholog showing functional complementation Supporting References ttv Hsap\EXT1 ( Dasgupta et al.,  2007 ) Interactions Summary of Physical Interactions Interaction Browsers View in FlyBase Interactions Browser View in MIST tool (external link) Please see the Physical Interaction reports below for full details protein-protein Physical Interaction Assay References ttv - botv anti tag coimmunoprecipitation , anti tag western blot ( Han et al.,  2004 ) ttv - sau anti tag coimmunoprecipitation , western blot ( Chang et al.,  2013 ) ttv - sotv anti tag coimmunoprecipitation , anti tag western blot ( Han et al.,  2004 ) Summary of Genetic Interactions Interaction Browsers View in FlyBase Interactions Browser View in MIST tool (external link) Please look at the allele data for full details of the genetic interactions Starting gene(s) Interaction type Interacting gene(s) Reference ttv enhanceable β3GalTII ( Ueyama et al.,  2008 ) Starting gene(s) Interaction type Interacting gene(s) Reference hh enhanceable ttv ( Deshpande et al.,  2007 ) hh suppressible ttv ( Gallet et al.,  2003 ) Psn suppressible ttv ( Reynolds-Peterson et al.,  2020 ) Sdc enhanceable ttv ( Chanana et al.,  2009 ) trol enhanceable ttv ( Park et al.,  2003 ) β3GalTII enhanceable ttv ( Ueyama et al.,  2008 ) External Data Subunit Structure (UniProtKB) Interacts with sau ( PubMed:23720043 ). (UniProt, Q9V730 ) Linkouts DroID -
                  A comprehensive database of gene and protein interactions. FBgn0265974 MIST (genetic) -
                  An integrated Molecular Interaction Database 36614 MIST (protein-protein) -
                  An integrated Molecular Interaction Database 36614 Pathways Signaling Pathways (FlyBase) Metabolic Pathways FlyBase HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHESIS External Links FlyCyc Pathways -
                  Pathways from a BioCyc PGDB for Dmel heme degradation I heparan sulfate biosynthesis serotonin degradation superpathway of heparan sulfate biosynthesis KEGG Metabolic Pathways -
                  A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks. Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways Reactome Metabolic Pathways -
                  An open-source, open access, manually curated and peer-reviewed metabolic pathway database. HS-GAG biosynthesis External Data Linkouts KEGG Pathways -
                  A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks. Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways Reactome -
                  An open-source, open access, manually curated and peer-reviewed pathway database. HS-GAG biosynthesis Class of Gene gene gene_with_edited_transcript ( Rodriguez et al.,  2012 , Graveley et al.,  2011 ) gene_with_stop_codon_read_through ( Jungreis et al.,  2016 ) nuclear_gene protein_coding_gene Genomic Location and Detailed Mapping Data Chromosome (arm) 2R Recombination map 2-72 Cytogenetic map 51A7-51B4 Sequence location 2R:14,526,267..14,587,917 [+] FlyBase Computed Cytological Location Cytogenetic map Evidence for location 51A7-51B4 Experimentally Determined Cytological Location Cytogenetic map Notes References 51B1-51B1 ( Oh et al.,  2003 ) 51B5-51B5 (determined by in situ hybridisation) ( Misra,  2000.8.25 ) 51A2-51B2 ( Bellaiche,  1998.8.13 ) 51B1-51B5 (determined by in situ hybridisation) ( Spradling et al.,  1999 , Perrimon et al.,  1996 ) 51A-51A (determined by in situ hybridisation) ( Bellaiche et al.,  1998 ) 51B1-51B2 51B7--8 ( BDGP Project Members,  1994-1999 ) Experimentally Determined Recombination Data Location 2-72 ( FlyBase,  2016 ) 2-76.0 ( Comeron et al.,  2012 ) 2- ( Dickson et al.,  1995 ) Left of (cM) Right of (cM) phyl ( Dickson et al.,  1995 ) Notes 36 recombinants in 31,272 progeny. ( Dickson et al.,  1995 ) Stocks and Reagents Stocks (29) Aberrations including deletions of this gene Aberrations including duplications of this gene Bloomington 81956 y 1 v 1 ; P{TKO.GS03487}attP40 51480 y 1 v 1 ; P{TRiP.HMC03225}attP40 40813 y 1 w * ; Mi{MIC}ttv MI06633 62650 w 1118 ; PBac{IT.GAL4}ttv 0123-G4 /CyO 41068 y 1 w * ; Mi{MIC}ttv MI05485 /SM6a Kyoto 112324 w * ; P{GawB}ttv NP0774 / CyO 124505 w 1118 ; P{RS3}LamC UM-8373-3 110612 y * w * P{PTT-GB}LamC G00158 NIG-Fly HMC03225 y 1 v 1 ; P{TRiP.HMC03225}attP40/CyO HMJ23211 y 1 v 1 ; P{TRiP.HMJ23211}attP40/CyO VDRC v330000 P{VSH330000}attP40 v4871 w 1118 ; P{GD1993}v4871 More stocks available... Genomic Clones
            (46) BACR06D02 BACR27M04 CH321-5N19 CH321-9B2 CH321-10I2 CH321-14F10 CH321-16P14 CH321-26O17 CH321-38N3 CH321-55F18 CH321-61B18 CH321-64O22 CH321-68A17 CH321-68A21 CH321-69K14 CH321-72G1 CH321-73P14 CH321-79A10 CH321-80C8 CH321-94N7 CH321-94O22 CH322-20H14 CH322-21N1 CH322-34A10 CH322-37B16 CH322-43N17 CH322-74I7 CH322-79O1 CH322-83G17 CH322-83I13 CH322-98P9 CH322-118C20 CH322-122E19 CH322-125O18 CH322-133I10 CH322-140C14 CH322-147L4 CH322-150G20 CH322-154J6 CH322-157N22 CH322-163A15 CH322-164E5 CH322-166M6 CH322-177C24 CH322-183F18 CH322-185M18 List GenBank IDs Please Note FlyBase no
                        longer curates genomic clone accessions so this list
                        may not be complete cDNA Clones
            (61) List GenBank IDs Clones Consistent with Transcripts Please Note This section lists cDNAs and ESTs that fall within the genomic extent
                        of the gene model, which may include cDNAs and ESTs
                        of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model. cDNA clones, fully sequenced BDGP DGC clones LD10920 Other clones DPiM_LD10920 MIP20656 Drosophila Genomics Resource Center cDNA clones For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged)
                    in several different host vectors for subsequent cloning and expression in Drosophila and
                    Drosophila cell lines. FBgn0265974 cDNA Clones, End Sequenced (ESTs) BDGP DGC clones LD03594 LD04489 LD09555 LD10959 LD10966 LD12905 LD19740 RE04512 RE04583 RE11780 RE21632 RE38376 RE54882 RE55182 RE55689 RE60264 RE61412 RE61571 RE67611 RH63565 SD14990 SD15993 SD21094 Other clones 976 29975 44085 60783 62008 214471.69 569971 CK01.80B.G7 CK01.113C.F4 CK02423 EK062228 EK121639 EK160260 EK185546 EK185619 EK200306 EN16010 FGM211H03 LD04003 LD10385 LD18275 RM05141 RM05241 RM05441 RM05641 RM06441 RP01033 RP001012746 RP001017426 RP001021430 RP001040904 RP001045105 RP001046398 RP001047803 RP001048758 RNAi and Array Information Linkouts Antibody Information Laboratory Generated Antibodies polyclonal ( Chang et al.,  2013 , The et al.,  1999 ) Commercially Available Antibodies Cell Line Information Publicly Available Cell Lines Other Stable Cell Lines Other Comments ttv is required for normal germ cell migration in the developing embryo. ( Deshpande et al.,  2007 ) ttv is necessary for normal levels of heparan sulphate glycosaminoglycan modification of dally and dlp gene products. ( Han et al.,  2004 ) ttv is required for transport of morphogens ( hh , wg , and dpp ) in the developing imaginal discs. ( Takei et al.,  2004 ) 8 alleles of l(2)SH0631 recovered in a P-insertion screen. ( Oh et al.,  2003 ) ttv is involved in heparan sulfate proteoglycan synthesis. ( The et al.,  1999 ) ttv is required for the diffusion of the hh gene product. ttv is a member of the EXT gene family. ( Bellaiche et al.,  1998 ) Mutants show maternal effect segment polarity phenotypes. ( Bellaiche et al.,  1998 ) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. ( Roch et al.,  1998 ) Isolated in a screen for lethal mutations affecting segmentation. ( Bellaiche et al.,  1997 ) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w hs )} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. ( Perrimon et al.,  1996 ) Relationship to Other Genes Source for database merge of Source for merge of: ttv l(2)00681 ( Bellaiche et al.,  1998 ) Source for merge of: ttv l(2)05282 l(2)k03617 ( Beaton,  1999.12.12 ) Source for merge of: ttv l(2)SH0631 ( Gurudatta et al.,  2010 ) Additional comments l(2)k03906b may correspond to ttv: the P{lacW}l(2)k03906b k03906b insertion maps within the transcription unit. ( Gene Disruption Project members,  2015.10.8 ) Nomenclature History Source for database identify of Nomenclature comments Etymology 'tout-velu' means 'all hair' in French. ( Bellaiche et al.,  1998 ) Synonyms and Secondary IDs  (22) Reported As Symbol Synonym CG10117 ( National Institute of Genetics Fly Stocks,  2023- , National Institute of Genetics Fly Stocks,  2022- , Meadows,  2017.1.11 , Butzlaff et al.,  2015 , Hosono et al.,  2015 , Yamamoto-Hino et al.,  2015 , Gurudatta et al.,  2010 , Ni et al.,  2010.12.1 , Izumikawa et al.,  2006 , Häcker et al.,  2005 , Norga et al.,  2003 , Kraut et al.,  2001 , Kraut et al.,  2001 , Mount,  2001.8.14 ) DEXT1 ( Nishihara,  2010 , Izumikawa et al.,  2006 , Wilson,  2002 ) EXT1 ( Nishihara,  2020 , Nakato and Li,  2016 ) Ext1 ( Wilson and Chuang,  2006 ) P1.15 ( Dickson et al.,  1995 ) Ttv ( Nishihara,  2020 , Nagarajan et al.,  2015 , Yamamoto-Hino et al.,  2015 , Mbodj et al.,  2013 , Raftery and Umulis,  2012 , Gallet et al.,  2006 ) dExt1 ( Yamamoto-Hino et al.,  2015 ) l(2)00681 ( Spradling et al.,  1999 ) l(2)05282 ( BDGP Project Members,  1994-1999 , Berkeley Drosophila Genome Project,  1993.6.1 ) l(2)SH0631 l(2)SH2 0631 ( Oh et al.,  2002.3.24 ) l(2)k00115 l(2)k03617 ( BDGP Project Members,  1994-1999 ) ttv ( Port et al.,  2026 , Deshpande et al.,  2025 , Patterson et al.,  2025 , Jiménez-Jiménez et al.,  2024 , Deshpande et al.,  2023 , Gude et al.,  2023 , Aguirre-Tamaral et al.,  2022 , López-Varea et al.,  2021 , Parniewska and Stocker,  2020 , Wei et al.,  2020 , Meltzer et al.,  2019 , Drelon et al.,  2018 , Gene Disruption Project members,  2018- , Kanai et al.,  2018 , Levings and Nakato,  2018 , Levis,  2018.8.30 , Poe et al.,  2017 , Reynolds-Peterson et al.,  2017 , Transgenic RNAi Project members,  2017- , Clandinin and Owens,  2016- , Jungreis et al.,  2016 , Levings et al.,  2016 , Nakato and Li,  2016 , Butzlaff et al.,  2015 , Gene Disruption Project members,  2015- , Ashwal-Fluss et al.,  2014 , He et al.,  2014 , Chang et al.,  2013 , Deshpande et al.,  2013 , Gradilla and Guerrero,  2013 , Sekine et al.,  2013 , Uchino et al.,  2013 , Cho et al.,  2012 , Rodriguez et al.,  2012 , Chang et al.,  2011 , Dejima et al.,  2011 , Toku et al.,  2011 , Wang et al.,  2011 , Gurudatta et al.,  2010 , Nishihara,  2010 , Pospisilik et al.,  2010 , Baron et al.,  2009 , Bischoff et al.,  2009 , Chanana et al.,  2009 , Hayashi et al.,  2009 , Maybeck and Röper,  2009 , Renault et al.,  2009 , Ren et al.,  2009 , Belenkaya et al.,  2008 , Bornemann et al.,  2008 , Christensen et al.,  2008.12.28 , Ueyama et al.,  2008 , Christensen and Cook,  2007.10.29 , Dasgupta et al.,  2007 , Deshpande et al.,  2007 , Eugster et al.,  2007 , Callejo et al.,  2006 , Gallet et al.,  2006 , Izumikawa et al.,  2006 , Wendler et al.,  2006 , Wilson and Chuang,  2006 , Yao et al.,  2006 , Briscoe and Therond,  2005 , Glise et al.,  2005 , Gorfinkiel et al.,  2005 , Häcker et al.,  2005 , Torroja et al.,  2005 , Stanyon et al.,  2004 , The et al.,  1999 ) Name Synonyms Tout velu ( Gallet et al.,  2006 ) Tout-velu ( Parniewska and Stocker,  2020 , Nakato and Li,  2016 , Nagarajan et al.,  2015 ) lethal (2) SH0631 tout velour ( Gradilla and Guerrero,  2013 ) tout velu ( Dejima et al.,  2011 , Gurudatta et al.,  2010 , Bischoff et al.,  2009 , Maybeck and Röper,  2009 , Dasgupta et al.,  2007 , Häcker et al.,  2005 , Torroja et al.,  2005 , Kuwabara and Labouesse,  2002 , Mann and Beachy,  2000 , The et al.,  1998 ) tout-velo ( He et al.,  2014 ) tout-velu ( Levings et al.,  2016 , Chanana et al.,  2009 , Hayashi et al.,  2009 , Bornemann et al.,  2008 , Eugster et al.,  2007 , Izumikawa et al.,  2006 , Wendler et al.,  2006 , Wilson and Chuang,  2006 , Eldar and Barkai,  2005 , Kraut et al.,  2001 , Kraut et al.,  2001 , The et al.,  1999 , Bellaiche,  1998.8.13 , Bellaiche et al.,  1997 ) toutvelu ( Deshpande et al.,  2007 ) Secondary FlyBase IDs FBgn0065697 FBgn0020245 FBgn0010469 FBgn0010592 FBgn0024670 Datasets (0) Study focus (0) Experimental Role Project Project Type Title Study result (0) Result Result Type Title External Crossreferences and Linkouts ( 71 ) Sequence Crossreferences NCBI Gene -
                  Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide. 36614 GenBank Nucleotide -
                  A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB. AB082204 AB221351 AC008306 AF083889 AQ025728 AQ026040 AQ026500 BH840616 BT021403 CZ467446 CZ468264 CZ468826 CZ470366 CZ474937 CZ479934 CZ479935 CZ481711 CZ485734 GenBank Protein -
                  A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB. AAC32397 AAF58236 AAX33551 AGB93503 AGB93504 BAE78509 QCD26199 RefSeq -
                  A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein. NM_057883 NM_001274042 NM_001274043 NM_001369957 NP_477231 NP_001260971 NP_001260972 UniProt/GCRP -
                  The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene. Q9V730 UniProt/Swiss-Prot -
                  Manually annotated and reviewed records of protein sequence and functional information Q9V730 UniProt/TrEMBL -
                  Automatically annotated and unreviewed records of protein sequence and functional information A0A0B4KER9 A0A4P7VB75 D5SHU8 Other crossreferences AlphaFold DB -
                  AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research. Q9V730 DRscDB -
                  A single-cell RNA-seq resource for data mining and data comparison across species 36614/tissue=All EMBL-EBI Single Cell Expression Atlas -
                  Single cell expression across species FBgn0265974 FlyAtlas2 -
                  A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data FBgn0265974 InterPro -
                  A database of protein families, domains and functional sites Exostosin-like Glycosyl transferase 64 domain Nucleotide-diphospho-sugar transferases Exostosin, GT47 domain KEGG Genes -
                  Molecular building blocks of life in the genomic space. dme:Dmel_CG10117 MARRVEL_MODEL -
                  MARRVEL (model organism gene) 36614 Linkouts Drosophila Genomics Resource Center -
                  Drosophila Genomics Resource Center (DGRC) cDNA clones FBgn0265974 DroID -
                  A comprehensive database of gene and protein interactions. FBgn0265974 Eukaryotic Promoter Database -
                  A collection of databases of experimentally validated promoters for selected model organisms. ttv_1 ttv_2 ttv_3 FlyAtlas -
                  Adult expression by tissue, using Affymetrix Dros2 array FBgn0020245 FlyCyc Genes -
                  Genes from a BioCyc PGDB for Dmel FBGN0265974 FlyCyc Pathways -
                  Pathways from a BioCyc PGDB for Dmel heme degradation I heparan sulfate biosynthesis serotonin degradation superpathway of heparan sulfate biosynthesis Fly-FISH -
                  A database of Drosophila embryo and larvae mRNA localization patterns CG10117 FlyMet -
                  A comprehensive tissue-specific metabolomics resource for Drosophila. FBgn0265974 iBeetle-Base -
                  RNAi phenotypes in the red flour beetle (Tribolium castaneum) TC004758 Interactive Fly -
                  A cyberspace guide to Drosophila development and metazoan evolution Interactive Fly KEGG Metabolic Pathways -
                  A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks. Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways KEGG Pathways -
                  A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks. Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways MIST (genetic) -
                  An integrated Molecular Interaction Database 36614 MIST (protein-protein) -
                  An integrated Molecular Interaction Database 36614 Reactome -
                  An open-source, open access, manually curated and peer-reviewed pathway database. HS-GAG biosynthesis Reactome Metabolic Pathways -
                  An open-source, open access, manually curated and peer-reviewed metabolic pathway database. HS-GAG biosynthesis References (214) Report Sections Open Close General Information Genomic Location Function Summaries Gene Model and Products Expression Data Gene ToolKit Alleles, Insertions, Constructs, and Aberrations Classical and Insertion Alleles Transgenic Constructs Aberrations (Deficiencies and Duplications) Variants Phenotypes Orthologs Human Orthologs Model Organism Orthologs Other Organism Orthologs Paralogs Human Disease Associations Functional Complementation Interactions Physical Interaction report Genetic interactions External Data Pathways Class of Gene Genomic Location and Mapping Stocks and Reagents Other Comments Relationship to Other Genes Nomenclature History Synonyms and Secondary IDs Datasets Crossreferences References version FB2026_02, released June 18, 2026 Contact FlyBase FAQ Citing FlyBase