ID   BCSQP_ECOLI             Reviewed;         242 AA.
AC   P37655;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 4.
DT   04-NOV-2026, entry version 140.
DE   RecName: Full=Putative cellulose biosynthesis protein BcsQ;
GN   Name=bcsQ; Synonyms=yhjQ; OrderedLocusNames=b3534;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   IDENTIFICATION OF MUTATION THAT GENERATES PSEUDOGENE, AND RESTORATION OF
RP   THE READING FRAME AND CELLULOSE PRODUCTION.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=24097954; DOI=10.1128/jb.00946-13;
RA   Serra D.O., Richter A.M., Hengge R.;
RT   "Cellulose as an architectural element in spatially structured Escherichia
RT   coli biofilms.";
RL   J. Bacteriol. 195:5540-5554(2013).
CC   -!- FUNCTION: A C-terminal pseudogene fragment of BcsQ, which has a
CC       premature stop codon at position 6 of the intact protein. The mutation
CC       prevents cellulose synthesis, and has polar effects on transcription of
CC       downstream gene bcsA and probably also bcsB, bcsZ and bcsC
CC       (PubMed:24097954). When the reading frame is restored cellulose
CC       biosynthesis is also restored, see (AC P0DP92) for an intact protein.
CC       May play a role in subcellular localization of an active cellulose
CC       biosynthesis apparatus at the bacterial cell pole (By similarity).
CC       {ECO:0000250|UniProtKB:P0DP92, ECO:0000305|PubMed:24097954}.
CC   -!- INDUCTION: Part of the yhjR-bcsQABZC operon (PubMed:24097954).
CC       {ECO:0000269|PubMed:24097954}.
CC   -!- MISCELLANEOUS: Cellulose production is abolished in E.coli K12 /MG1655
CC       and W3110 due to a premature stop codon in this gene. The sequence
CC       given here starts on a GTG codon 6 nucleotides downstream of the
CC       premature stop codon. {ECO:0000269|PubMed:24097954}.
CC   -!- SIMILARITY: Belongs to the BcsQ family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. The protein is missing 8
CC       N-terminal amino acids due to a premature stop codon; when the reading
CC       frame is restored strain W3110 synthesizes cellulose. See (AC P0DP92)
CC       for a functional intact protein. {ECO:0000305|PubMed:24097954}.
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DR   EMBL; U00039; AAB18512.1; -; Genomic_DNA.
DR   EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S47756; S47756.
DR   RefSeq; WP_011310329.1; NZ_CP009789.1.
DR   AlphaFoldDB; P37655; -.
DR   SMR; P37655; -.
DR   DIP; DIP-12388N; -.
DR   FunCoup; P37655; 51.
DR   IntAct; P37655; 2.
DR   jPOST; P37655; -.
DR   KEGG; ecoc:C3026_19145; -.
DR   EchoBASE; EB2170; -.
DR   InParanoid; P37655; -.
DR   OrthoDB; 5288747at2; -.
DR   PhylomeDB; P37655; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   FunFam; 3.40.50.300:FF:000943; Cellulose synthase operon protein YhjQ; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR017746; Cellulose_synthase_operon_BcsQ.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR050625; ParA/MinD_ATPase.
DR   NCBIfam; NF007460; bcsQ; 1.
DR   NCBIfam; TIGR03371; cellulose_yhjQ; 1.
DR   PANTHER; PTHR43384:SF4; CELLULOSE BIOSYNTHESIS PROTEIN BCSQ-RELATED; 1.
DR   PANTHER; PTHR43384; SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED; 1.
DR   Pfam; PF06564; CBP_BcsQ; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   5: Uncertain;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..242
FT                   /note="Putative cellulose biosynthesis protein BcsQ"
FT                   /id="PRO_0000169575"
FT   BINDING         1..8
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  27140 MW;  C4DD72EC40E124A9 CRC64;
     MRGGVGTTTI TAALAWSLQM LGENVLVVDA CPDNLLRLSF NVDFTHRQGW ARAMLDGQDW
     RDAGLRYTSQ LDLLPFGQLS IEEQENPQHW QTRLSDICSG LQQLKASGRY QWILIDLPRD
     ASQITHQLLS LCDHSLAIVN VDANCHIRLH QQALPDGAHI LINDFRIGSQ VQDDIYQLWL
     QSQRRLLPML IHRDEAMAEC LAAKQPVGEY RSDALAAEEI LTLANWCLLN YSGLKTPVGS
     AS
//