dewA

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005199 structural constituent of cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: structural constituent of cell wall. Reason: Hydrophobins act structurally rather than catalytically: DewA self-assembles into an amphipathic monolayer that is a physical constituent of the conidial surface. This is the correct molecular-function class for the protein.
GO:0005576 extracellular region	IEA GO_REF:0000044	ACCEPT	Summary: Accept: extracellular region. Reason: DewA is secreted and assembles after export, so the extracellular assignment follows from its secretory route; the wall terms below are the more specific locations.
GO:0009277 fungal-type cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: fungal-type cell wall. Reason: The DewA layer sits on the outer face of the conidial (fungal) wall. In GO, spore wall is not a descendant of fungal-type cell wall, so this domain-based call is retained as a broader, compatible location; note that immunolocalization places DewA in the spore wall only, not in hyphal or conidiophore walls. Supporting Evidence: PMID:7651135 DewA is present in the spore wall, but not in the walls of germ tubes, hyphae or cells of the spore-producing conidiophore
GO:0031160 spore wall	IEA GO_REF:0000044	ACCEPT	Summary: Accept: spore wall. Reason: The more specific wall location, matching the gene's original characterisation as encoding a component of the Aspergillus spore wall.
GO:0005576 extracellular region	EXP PMID:20567818 Recombinant production of an Aspergillus nidulans class I hy...	ACCEPT	Summary: Accept: extracellular region. Reason: Heterologous production and recovery of recombinant DewA from a Hypocrea jecorina host; the protein behaves as a secreted, extracellular species.
GO:0005576 extracellular region	EXP PMID:24722460 Six hydrophobins are involved in hydrophobin rodlet formatio...	ACCEPT	Summary: Accept: extracellular region. Reason: A second experimental line, from the six-hydrophobin survey in which rodlet formation and surface hydrophobicity are scored on the outside of the cell. Supporting Evidence: PMID:24722460 In Aspergillus nidulans two hydrophobins, RodA and DewA, have been characterized, which both localize on the conidiospore surface and contribute to its hydrophobicity.
GO:0005576 extracellular region	EXP PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Accept: extracellular region. Reason: A third line, from the paper that identified dewA as encoding a spore-wall hydrophobin component; the extracellular call is the general form of that placement.
GO:0031160 spore wall	EXP PMID:24722460 Six hydrophobins are involved in hydrophobin rodlet formatio...	ACCEPT	Summary: Accept: spore wall. Reason: Spore-wall placement scored through rodlet formation and conidial hydrophobicity across the multi-hydrophobin mutant series. Supporting Evidence: PMID:24722460 In Aspergillus nidulans two hydrophobins, RodA and DewA, have been characterized, which both localize on the conidiospore surface and contribute to its hydrophobicity.
GO:0031160 spore wall	IDA PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Accept: spore wall. Reason: The primary direct evidence: dewA was characterised as encoding a hydrophobin component of the Aspergillus spore wall. This row anchors the electronic wall terms above.
GO:0042243 asexual spore wall assembly	IMP PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Core process. DewA is a structural component built into the conidial wall; its loss leaves conidia morphologically normal but alters spore-wall hydrophobicity (detergent-wettable phenotype). Reason: DewA is a hydrophobin component of the spore wall accumulating during asexual sporulation; as a wall constituent it contributes structurally to the assembled wall's hydrophobic surface, independently of RodA. Supporting Evidence: PMID:7651135 dewA and rodA contribute independently to spore-wall hydrophobicity PMID:7651135 The peptide encoded by pCAN4 is a fungal hydrophobin, a group of small, hydrophobic cell wall proteins
GO:0031160 spore wall	IEA GO_REF:0000120	ACCEPT	Summary: Accept: spore wall (combined automated IEA, ARBA + SubCell mapping). Reason: Current electronic replacement for the retired GO_REF:0000044 spore-wall row. Consistent with the experimental placement of DewA on the conidiospore surface (IDA PMID:7651135; EXP PMID:24722460). Supporting Evidence: PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergillus spore wall. PMID:24722460 In Aspergillus nidulans two hydrophobins, RodA and DewA, have been characterized, which both localize on the conidiospore surface and contribute to its hydrophobicity.