Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005199 structural constituent of cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: structural constituent of cell wall. Reason: Hydrophobins act structurally rather than catalytically: DewA self-assembles into an amphipathic monolayer that is a physical constituent of the conidial surface. This is the correct molecular-function class for the protein.
GO:0005576 extracellular region	IEA GO_REF:0000044	ACCEPT	Summary: Accept: extracellular region. Reason: DewA is secreted and assembles after export, so the extracellular assignment follows from its secretory route; the wall terms below are the more specific locations.
GO:0009277 fungal-type cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: fungal-type cell wall. Reason: The DewA layer sits on the outer face of the fungal-type wall. Retained alongside the spore-wall term because hydrophobin coats are not confined to spores.
GO:0031160 spore wall	IEA GO_REF:0000044	ACCEPT	Summary: Accept: spore wall. Reason: The more specific wall location, matching the gene's original characterisation as encoding a component of the Aspergillus spore wall.
GO:0005576 extracellular region	EXP PMID:20567818 Recombinant production of an Aspergillus nidulans class I hy...	ACCEPT	Summary: Accept: extracellular region. Reason: Heterologous production and recovery of recombinant DewA from a Hypocrea jecorina host; the protein behaves as a secreted, extracellular species.
GO:0005576 extracellular region	EXP PMID:24722460 Six hydrophobins are involved in hydrophobin rodlet formatio...	ACCEPT	Summary: Accept: extracellular region. Reason: A second experimental line, from the six-hydrophobin survey in which rodlet formation and surface hydrophobicity are scored on the outside of the cell.
GO:0005576 extracellular region	EXP PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Accept: extracellular region. Reason: A third line, from the paper that identified dewA as encoding a spore-wall hydrophobin component; the extracellular call is the general form of that placement.
GO:0031160 spore wall	EXP PMID:24722460 Six hydrophobins are involved in hydrophobin rodlet formatio...	ACCEPT	Summary: Accept: spore wall. Reason: Spore-wall placement scored through rodlet formation and conidial hydrophobicity across the multi-hydrophobin mutant series.
GO:0031160 spore wall	IDA PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Accept: spore wall. Reason: The primary direct evidence: dewA was characterised as encoding a hydrophobin component of the Aspergillus spore wall. This row anchors the electronic wall terms above.
GO:0042243 asexual spore wall assembly	IMP PMID:7651135 dewA encodes a fungal hydrophobin component of the Aspergill...	ACCEPT	Summary: Core process. DewA is required for spore-wall assembly. Reason: DewA is a hydrophobin component of the spore wall accumulating during asexual sporulation. Supporting Evidence: PMID:7651135 The peptide encoded by pCAN4 is a fungal hydrophobin, a group of small, hydrophobic cell wall proteins

Core Functions

Class I spore-wall hydrophobin: DewA is a small hydrophobic cell-wall protein that, with RodA, forms the conidial surface layer conferring spore hydrophobicity.

Molecular Function:

structural constituent of cell wall

Directly Involved In:

asexual spore wall assembly

Cellular Locations:

spore wall extracellular region

Supporting Evidence:

PMID:7651135
The peptide encoded by pCAN4 is a fungal hydrophobin, a group of small, hydrophobic cell wall proteins

References

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Notes

(dewA-notes.md)

dewA (Aspergillus nidulans) — curation notes

UniProt P52750 (DEWA_EMENI). Class I spore-wall hydrophobin; structural-output tier.
- Fungal hydrophobin component of the spore wall. [PMID:7651135 "dewA encodes a fungal hydrophobin component of the Aspergillus spore wall"; "The peptide encoded by pCAN4 is a fungal hydrophobin, a group of small, hydrophobic cell wall proteins"].
- Core MF GO:0005199 structural constituent of cell wall; BP asexual spore wall assembly.

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