Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	IBA GO_REF:0000033	ACCEPT	Summary: Accept: DNA-binding transcription factor activity, RNA polymerase II-specific. Reason: C2H2 zinc-finger factors bind Pol II promoters; the family call fits FlbC's predicted architecture and its position upstream of brlA/abaA in this cascade.
GO:0006357 regulation of transcription by RNA polymerase II	IBA GO_REF:0000033	ACCEPT	Summary: Accept: regulation of transcription by RNA polymerase II. Reason: The process counterpart of the molecular function above. FlbC's characterised effect is on developmental gene transcription rather than on any other cellular process.
GO:0005634 nucleus	IBA GO_REF:0000033	ACCEPT	Summary: Accept: nucleus. Reason: Nuclear action is required for the transcription-factor role and is directly observed in this review; is_active_in is the right qualifier for the site of the regulatory activity.
GO:0005634 nucleus	IEA GO_REF:0000044	ACCEPT	Summary: Accept: nucleus. Reason: Predicted nuclear location, concordant with (and redundant to) the direct observation from PMID:20624219.
GO:0048315 conidium formation	IMP PMID:20624219 FlbC is a putative nuclear C2H2 transcription factor regulat...	ACCEPT	Summary: Core process. FlbC regulates conidium formation. Reason: FlbC is an upstream developmental activator required for normal conidiation. Supporting Evidence: PMID:20624219 The deletion of flbC causes a delay/reduction in conidiation, brlA and vosA expression, and conidial germination. PMID:20624219 In summary, FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans.
GO:0006357 regulation of transcription by RNA polymerase II	IMP PMID:20624219 FlbC is a putative nuclear C2H2 transcription factor regulat...	ACCEPT	Summary: Accept: regulation of transcription by RNA polymerase II. Reason: Mutational evidence from the study that characterised FlbC as a nuclear C2H2 factor regulating development. This is the primary support for the term.
GO:0006357 regulation of transcription by RNA polymerase II	IMP PMID:21624998 Regulation of conidiation by light in Aspergillus nidulans.	ACCEPT	Summary: Accept: regulation of transcription by RNA polymerase II. Reason: Independent mutational support in the light-regulated conidiation study; the same term from a separate genetic background.
GO:0005634 nucleus	IDA PMID:20624219 FlbC is a putative nuclear C2H2 transcription factor regulat...	ACCEPT	Summary: Accept: nucleus. Reason: Direct localisation. Note that the source describes FlbC as a putative C2H2 factor, so its location is better established here than its DNA-binding activity.
GO:0009847 spore germination	IMP PMID:20624219 FlbC is a putative nuclear C2H2 transcription factor regulat...	KEEP AS NON CORE	Summary: FlbC also affects spore germination (non-core). Reason: FlbC influences spore germination in addition to conidiation; a secondary role.
GO:0075306 regulation of conidium formation	IMP PMID:20624219 FlbC is a putative nuclear C2H2 transcription factor regulat...	ACCEPT	Summary: Core process. FlbC regulates conidium formation. Reason: FlbC modulates the frequency/extent of conidiation as an upstream activator. Supporting Evidence: PMID:20624219 The deletion of flbC causes a delay/reduction in conidiation, brlA and vosA expression, and conidial germination. PMID:20624219 In summary, FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans.

Core Functions

Upstream nuclear C2H2 transcription factor activating conidiation: FlbC contributes to brlA induction and regulation of conidium formation, acting in parallel with FlbB and FlbD.

Molecular Function:

DNA-binding transcription factor activity, RNA polymerase II-specific

Directly Involved In:

regulation of conidium formation conidium formation regulation of transcription by RNA polymerase II

Cellular Locations:

nucleus

Supporting Evidence:

PMID:20624219
The deletion of flbC causes a delay/reduction in conidiation, brlA and vosA expression, and conidial germination.
PMID:20624219
In summary, FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans.

References

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Notes

(flbC-notes.md)

flbC (Aspergillus nidulans) — curation notes

UniProt G5EAS8 (FLBC_EMENI). Nuclear C2H2 transcription factor; upstream
developmental activator. Upstream-activation tier of the module.

Putative nuclear C2H2 TF regulating development; also affects spore germination.
PMID:20624219.
Core MF GO:0000981; spore germination (GO:0009847) kept non-core.

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