Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0043935 sexual sporulation resulting in formation of a cellular spore	IMP PMID:20817115 Characterization of the developmental regulator FlbE in Aspe...	KEEP AS NON CORE	Summary: FlbE also affects sexual sporulation (non-core). Reason: A secondary role in sexual development alongside its main asexual-activator function.
GO:0048315 conidium formation	IMP PMID:19007409 Aspergillus nidulans FlbE is an upstream developmental activ...	ACCEPT	Summary: Core process. FlbE is required for conidium formation. Reason: FlbE is an upstream developmental activator required for conidiation. Supporting Evidence: PMID:19007409 In this report, we describe FlbE as a UDA containing two conserved but hitherto uncharacterized domains, which functions in close association with putative transcription factor FlbB. PMID:19007409 Mutants affected in these factors remain aconidial (fluffy) with low brlA expression levels (flb).
GO:0043943 regulation of asexual sporulation resulting in formation of a cellular spore	IMP PMID:20817115 Characterization of the developmental regulator FlbE in Aspe...	ACCEPT	Summary: Core process. FlbE regulates asexual sporulation. Reason: FlbE positively regulates asexual sporulation as an upstream activator. Supporting Evidence: PMID:20817115 The deletion of flbE causes reduced conidiation and delayed expression of brlA and vosA in both species.
GO:0001411 hyphal tip	IDA PMID:19007409 Aspergillus nidulans FlbE is an upstream developmental activ...	ACCEPT	Summary: Hyphal-tip localization (with FlbB). Reason: FlbE localizes to the hyphal tip, where it associates with FlbB. Supporting Evidence: PMID:19007409 Both UDAs are functionally interdependent, and colocalize at the hypha tip in an actin cytoskeleton-dependent manner.
GO:0001411 hyphal tip	IPI PMID:19007409 Aspergillus nidulans FlbE is an upstream developmental activ...	ACCEPT	Summary: Hyphal-tip localization / FlbB interaction. Reason: FlbE physically associates with FlbB at the hyphal tip. Supporting Evidence: PMID:19007409 Moreover, bimolecular fluorescence studies show that they physically interact in vivo.
GO:0075307 positive regulation of conidium formation	IMP PMID:19007409 Aspergillus nidulans FlbE is an upstream developmental activ...	ACCEPT	Summary: Core process. FlbE positively regulates conidium formation. Reason: flbE mutants are delayed/deficient in conidiation. Supporting Evidence: PMID:19007409 Mutants affected in these factors remain aconidial (fluffy) with low brlA expression levels (flb). PMID:20817115 The deletion of flbE causes reduced conidiation and delayed expression of brlA and vosA in both species.

Core Functions

Accessory upstream activator of conidiation: FlbE associates with the bZIP factor FlbB at the hyphal tip and is required for FlbB activity and timely induction of conidiation. FlbE has no characterized molecular (catalytic or DNA-binding) activity of its own.

Directly Involved In:

positive regulation of conidium formation conidium formation

Cellular Locations:

hyphal tip

Supporting Evidence:

PMID:19007409
Both UDAs are functionally interdependent, and colocalize at the hypha tip in an actin cytoskeleton-dependent manner.
PMID:20817115
The deletion of flbE causes reduced conidiation and delayed expression of brlA and vosA in both species.

References

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📚 Additional Documentation

Notes

(flbE-notes.md)

flbE (Aspergillus nidulans) — curation notes

UniProt Q5BFF9 (FLBE_EMENI). Small accessory upstream developmental activator.
Upstream-activation tier of the module.

Upstream developmental activator functionally/physically associated with FlbB at
the hyphal tip; required for FlbB activity and conidiation.
PMID:19007409.
No molecular_function asserted (no characterized catalytic/DNA-binding activity).

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