Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005199 structural constituent of cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: structural constituent of cell wall. Reason: Hydrophobins act structurally rather than catalytically: RodA self-assembles into the amphipathic rodlet monolayer, a physical constituent of the conidial surface. This is the correct molecular-function class.
GO:0005576 extracellular region	IEA GO_REF:0000044	ACCEPT	Summary: Accept: extracellular region. Reason: RodA is secreted and assembles after export, so an extracellular assignment follows from its secretory route; the wall terms below are the more specific locations.
GO:0009277 fungal-type cell wall	IEA GO_REF:0000002	ACCEPT	Summary: Accept: fungal-type cell wall. Reason: The rodlet layer sits on the outer face of the fungal-type wall. Retained alongside the spore-wall term because RodA also coats aerial structures, not spores alone.
GO:0031160 spore wall	IEA GO_REF:0000044	ACCEPT	Summary: Accept: spore wall. Reason: The more specific of the two wall locations, and the one where RodA matters most: the rodlet layer is what confers conidial surface hydrophobicity.
GO:0005576 extracellular region	EXP PMID:2065971 Rodletless, a new Aspergillus developmental mutant induced b...	ACCEPT	Summary: Accept: extracellular region. Reason: Experimental support from the rodletless mutant, in which directed inactivation of rodA removes the surface rodlet layer; the structure scored is extracellular.
GO:0031160 spore wall	EXP PMID:2065971 Rodletless, a new Aspergillus developmental mutant induced b...	ACCEPT	Summary: Accept: spore wall. Reason: The same rodletless mutant evidence read at the spore-wall level. This is the primary experimental grounding for RodA's location.
GO:0031160 spore wall	IDA PMID:15691953 Assessment of elasticity and topography of Aspergillus nidul...	ACCEPT	Summary: Accept: spore wall. Reason: Atomic-force microscopy of A. nidulans spore surfaces, cited by the curator as direct evidence for the rodlet layer's spore-wall placement; independent of the mutant data above.
GO:0042243 asexual spore wall assembly	IMP PMID:2065971 Rodletless, a new Aspergillus developmental mutant induced b...	ACCEPT	Summary: Core process. RodA is required for spore-wall (rodlet-layer) assembly. Reason: Disruption of rodA (CAN41) removes the conidial rodlet layer (rodletless phenotype). Supporting Evidence: PMID:2065971 Disruption of CAN41 results in a novel mutant phenotype in which conidiophore cells and spores lack an external wall layer, the rodlet layer, making them less hydrophobic than in the wild type and leading to inefficient spore dispersal

Core Functions

Class I hydrophobin forming the conidial rodlet layer: RodA self-assembles into the outer hydrophobic rodlet mosaic of the spore wall, conferring surface hydrophobicity and dispersal.

Molecular Function:

structural constituent of cell wall

Directly Involved In:

asexual spore wall assembly

Cellular Locations:

spore wall extracellular region

Supporting Evidence:

PMID:2065971
Disruption of CAN41 results in a novel mutant phenotype in which conidiophore cells and spores lack an external wall layer, the rodlet layer, making them less hydrophobic than in the wild type and leading to inefficient spore dispersal

References

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Notes

(rodA-notes.md)

rodA (Aspergillus nidulans) — curation notes

UniProt P28346 (RODA_EMENI). Class I hydrophobin (rodlet layer); structural-output tier.
- brlA-activated (CAN41) hydrophobin; disruption gives rodletless conidia. PMID:2065971.
- Core MF GO:0005199 structural constituent of cell wall; BP asexual spore wall assembly (GO:0042243).

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