id: A0A9L0IX39
gene_symbol: CADM1
taxon:
  id: NCBITaxon:9793
  label: Equus asinus
status: COMPLETE
description: Assessment of the single ProtNLM2 GO prediction for donkey CADM1 (A0A9L0IX39), a single-pass
  type I transmembrane Ig-superfamily adhesion molecule 96% identical to human CADM1 over its extracellular
  and transmembrane regions. The prediction membrane (GO:0016020) is correct but less precise than the donkey
  GOA plasma membrane annotation (LSP). ProtNLM2 emitted no function text or subcellular location for this
  accession.
source_documents:
- projects/PROTNLM_EVALUATION/donkey40/donkey40-predictions.tsv
- projects/PROTNLM_EVALUATION/donkey40/donkey40-evidence.tsv
- genes/EQUAS/CADM1/CADM1-uniprot.txt
- genes/EQUAS/CADM1/CADM1-goa.tsv
- genes/EQUAS/CADM1/CADM1-bioinformatics/human-CADM1-Q9BY67-uniprot.txt
- genes/EQUAS/CADM1/CADM1-bioinformatics/RESULTS.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-10-14
  predicted_term:
    id: GO:0016020
    label: membrane
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Human CADM1 is experimentally localized to the cell membrane as a single-pass type I protein,
      and the donkey sequence conserves the signal peptide, Ig-like ectodomain and transmembrane helix, so
      membrane localization is well supported. Donkey GOA already holds the more specific plasma membrane
      (GO:0005886) annotation, which is also the GO term named in the ProtNLM2 evidence record. The prediction
      is correct but less precise than an existing annotation.
    supported_by:
    - reference_id: file:EQUAS/CADM1/CADM1-bioinformatics/human-CADM1-Q9BY67-uniprot.txt
      supporting_text: 'SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11279526,'
    - reference_id: file:EQUAS/CADM1/CADM1-bioinformatics/RESULTS.md
      supporting_text: Its extracellular region (three Ig-like domains), stalk and transmembrane segment are
        conserved.
references:
- id: file:EQUAS/CADM1/CADM1-bioinformatics/human-CADM1-Q9BY67-uniprot.txt
  title: UniProt record for human CADM1 (Q9BY67)
  findings: []
- id: file:EQUAS/CADM1/CADM1-bioinformatics/RESULTS.md
  title: 'CADM1: donkey-human sequence comparison'
  findings: []