ID   A0A8C4MKL2_EQUAS        Unreviewed;       356 AA.
AC   A0A8C4MKL2;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   02-SEP-2026, entry version 21.
DE   RecName: Full=Endosome-associated-trafficking regulator 1 {ECO:0000256|ARBA:ARBA00016007};
GN   Name=ENTR1 {ECO:0000313|Ensembl:ENSEASP00005027020.2};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005027020.2, ECO:0000313|Proteomes:UP000694387};
RN   [1] {ECO:0000313|Ensembl:ENSEASP00005027020.2, ECO:0000313|Proteomes:UP000694387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33293529;
RA   Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA   Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA   C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA   J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA   Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA   Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA   S., Zhou, X. and Zhong, J.;
RT   "Donkey genomes provide new insights into domestication and selection for
RT   coat color.";
RL   Nat. Commun. 11:6014-6014(2020).
RN   [2] {ECO:0000313|Ensembl:ENSEASP00005027020.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ENTR1 family.
CC       {ECO:0000256|ARBA:ARBA00007791}.
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DR   AlphaFoldDB; A0A8C4MKL2; -.
DR   Ensembl; ENSEAST00005029330.2; ENSEASP00005027020.2; ENSEASG00005018403.2.
DR   GeneTree; ENSGT00390000000560; -.
DR   Proteomes; UP000694387; Chromosome 10.
DR   GO; GO:0005813; C:centrosome; IEA:TreeGrafter.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0005769; C:early endosome; IEA:TreeGrafter.
DR   GO; GO:0030496; C:midbody; IEA:TreeGrafter.
DR   GO; GO:0055037; C:recycling endosome; IEA:TreeGrafter.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; IEA:TreeGrafter.
DR   GO; GO:1903566; P:positive regulation of protein localization to cilium; IEA:TreeGrafter.
DR   GO; GO:0032465; P:regulation of cytokinesis; IEA:TreeGrafter.
DR   InterPro; IPR026757; ENTR1.
DR   InterPro; IPR063798; ENTR1_CC.
DR   PANTHER; PTHR31259; ENDOSOME-ASSOCIATED TRAFFICKING REGULATOR 1; 1.
DR   PANTHER; PTHR31259:SF3; ENDOSOME-ASSOCIATED-TRAFFICKING REGULATOR 1; 1.
DR   Pfam; PF29363; ENTR1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694387}.
FT   DOMAIN          178..347
FT                   /note="ENTR1 coiled coil region"
FT                   /evidence="ECO:0000259|Pfam:PF29363"
FT   REGION          49..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          185..286
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        49..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..107
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  39331 MW;  FDF57BA88CB00741 CRC64;
     QPPVHAAPVG LSACTGAEAD DKLEDLEEAN PFSFKEFLKA KSLGLSKEDT TDSRIYAKEA
     PRHSLGLDRD SPTSQTGGYG LEYQQPFFED PTGAGDLLDE DEDEDDGWNG AYLPSAVEQS
     HSSRVLASTS PCSTYVSFFS NPSELVGPES LPPWTLSDSE SRVSPAGSPG TDFAAHGESL
     GDRHLRTLQI SYEALKDENS KLRRKLTEVQ SFSETQTEMV RTLERKLEAK MIKEESDYHD
     LESVVQQVEQ NLELMTKRAV KAENHIMKLK QEVSLLQAQV TNFKRENEAL RSGQGASLTV
     VKQNTEVALQ NLHMVMNNAH TSIKQLVSGA ETLNLVAEIL KSIDRISEIK EEEESS
//