id: A0A9L0ICL9
gene_symbol: GEMIN7
taxon:
  id: NCBITaxon:9793
  label: Equus asinus
status: COMPLETE
description: 'Assessment of 1 ProtNLM2 GO prediction for donkey GEMIN7 (A0A9L0ICL9), judged against the
  donkey GOA record (spliceosomal snRNP assembly, SMN-Sm protein complex, Sm-like protein family complex,
  RNA binding, cytoplasm, nucleoplasm, Gemini of Cajal bodies), the human ortholog Q9H840 and cached SMN-complex
  studies (PMID:12065586, PMID:17178713), and a donkey-human alignment (88% identity over the complete human
  sequence). Sm-like protein family complex is correct and is itself in donkey GOA, but the GOA record also
  carries its more specific descendant SMN-Sm protein complex, so the prediction is scored as less precise
  (LSP). Non-GO ProtNLM2 output, not scored: subcellular location ''Nucleus'', consistent with the nucleoplasm
  and gem localization of human GEMIN7 but omitting its cytoplasmic pool. No function text was emitted
  for this accession.'
source_documents:
- projects/PROTNLM_EVALUATION/donkey40/donkey40-predictions.tsv
- genes/EQUAS/GEMIN7/GEMIN7-goa.tsv
- genes/EQUAS/GEMIN7/GEMIN7-bioinformatics/human-Q9H840-uniprot.txt
- genes/EQUAS/GEMIN7/GEMIN7-bioinformatics/RESULTS.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-10-14
  predicted_term:
    id: GO:0120114
    label: Sm-like protein family complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Human GEMIN7 is a core SMN-complex subunit that binds SMN, GEMIN6 and Sm proteins (PMID:12065586)
      and sits at the centre of the complex with SMN and GEMIN8 (PMID:17178713); the donkey protein covers
      the complete human sequence at 88% identity. Membership of an Sm-like protein family complex is
      therefore correct. The exact term is present in donkey GOA (TreeGrafter), but donkey GOA also carries
      SMN-Sm protein complex, a more specific descendant of this term, so the prediction is correct but
      less precise than an existing annotation. Training-set membership is unknown.
    supported_by:
    - reference_id: PMID:12065586
      supporting_text: Gemin7 is a component of the SMN complex
    - reference_id: PMID:17178713
      supporting_text: SMN, Gemin8, and Gemin7 in its center
    - reference_id: file:EQUAS/GEMIN7/GEMIN7-bioinformatics/human-Q9H840-uniprot.txt
      supporting_text: Part of the SMN-Sm complex that contains SMN1
    - reference_id: file:EQUAS/GEMIN7/GEMIN7-bioinformatics/RESULTS.md
      supporting_text: donkey residues 76-206 align without gaps to the complete human protein (1-131) at
        87.79% identity
references:
- id: file:EQUAS/GEMIN7/GEMIN7-goa.tsv
  title: Donkey GEMIN7 GOA annotations
  findings: []
- id: file:EQUAS/GEMIN7/GEMIN7-bioinformatics/human-Q9H840-uniprot.txt
  title: UniProt record for human GEMIN7 (Q9H840)
  findings: []
- id: file:EQUAS/GEMIN7/GEMIN7-bioinformatics/RESULTS.md
  title: 'GEMIN7: donkey-human sequence comparison'
  findings: []
- id: PMID:12065586
  title: Identification and characterization of Gemin7, a novel component of the survival of motor neuron
    complex.
  findings: []
- id: PMID:17178713
  title: A comprehensive interaction map of the human survival of motor neuron (SMN) complex.
  findings: []