ID   A0A9L0J2B1_EQUAS        Unreviewed;       565 AA.
AC   A0A9L0J2B1;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   02-SEP-2026, entry version 14.
DE   RecName: Full=Glypican-3 {ECO:0000256|ARBA:ARBA00014712};
GN   Name=GPC3 {ECO:0000313|Ensembl:ENSEASP00005043430.1};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005043430.1, ECO:0000313|Proteomes:UP000694387};
RN   [1] {ECO:0000313|Ensembl:ENSEASP00005043430.1, ECO:0000313|Proteomes:UP000694387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33293529;
RA   Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA   Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA   C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA   J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA   Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA   Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA   S., Zhou, X. and Zhong, J.;
RT   "Donkey genomes provide new insights into domestication and selection for
RT   coat color.";
RL   Nat. Commun. 11:6014-6014(2020).
RN   [2] {ECO:0000313|Ensembl:ENSEASP00005043430.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU003519}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004471};
CC       Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004471}; Extracellular
CC       side {ECO:0000256|ARBA:ARBA00004471}.
CC   -!- SIMILARITY: Belongs to the glypican family.
CC       {ECO:0000256|ARBA:ARBA00010260, ECO:0000256|RuleBase:RU003518}.
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DR   AlphaFoldDB; A0A9L0J2B1; -.
DR   Ensembl; ENSEAST00005057340.1; ENSEASP00005043430.1; ENSEASG00005018489.2.
DR   GeneTree; ENSGT01050000244955; -.
DR   Proteomes; UP000694387; Chromosome X.
DR   GO; GO:0009986; C:cell surface; IEA:TreeGrafter.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:TreeGrafter.
DR   GO; GO:1905475; P:regulation of protein localization to membrane; IEA:TreeGrafter.
DR   InterPro; IPR001863; Glypican.
DR   InterPro; IPR019803; Glypican_CS.
DR   PANTHER; PTHR10822; GLYPICAN; 1.
DR   PANTHER; PTHR10822:SF4; GLYPICAN-3; 1.
DR   Pfam; PF01153; Glypican; 1.
DR   PROSITE; PS01207; GLYPICAN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor {ECO:0000256|ARBA:ARBA00022622, ECO:0000256|RuleBase:RU003519};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW   ECO:0000256|RuleBase:RU003519};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU003519};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003519};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW   ECO:0000256|RuleBase:RU003519};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ   SEQUENCE   565 AA;  64423 MW;  078D200EFE847C78 CRC64;
     MSFQFAPGGC YGHARVFDCQ MVMMMEARMF IFWPRFWKGT PNKGSDLQVC LPKGPTCCSR
     KMEEKYQLTA RLNMEQLLQS ASMELKFLII QNAAVFQEAF EIVVRHAKNY TNAMFKNNYP
     SLTPQAFEFV GEFFTDVSLY ILGSDINVDD MVNELFDSLF PVIYTQLMNP GLPESTLDIN
     ECLRGARRDL KVFGNFPKLI MTQVSKSLQV TRIFLQALNL GIEVINTTDH LKFSKDCSRM
     LTRMWYCSYC QGLMMVKPCG GYCNVVMQGC MAGVVEIDKY WREYILSLEE LVNGMYRIYD
     MENVLLGLFS TIHDSIQYVQ KNGGKLTTTI GKLCAHSQQR QYRSAYYPED LFIDKKVLKV
     AHVEHEETLS SRRRELIQKL KSFISFYSAL PGYICSHSPV AENDTLCWNG QELVERYSQK
     AARNGMKNQF NLHELKMKGP EPVVSQIIDK LKHINQLLRT MSVPKGRVLD KNLDEEGLES
     GDCGDDEDEC IGGSGDGMMK VKNQLRFLAE LAYDLDVDDA PGSNQHVNQK DNEIVASHNL
     GNGHSPLKVL TSLAIYVVCF FFLVH
//