ID   A0A9L0I7X9_EQUAS        Unreviewed;       421 AA.
AC   A0A9L0I7X9;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   02-SEP-2026, entry version 15.
DE   RecName: Full=Interferon regulatory factor 9 {ECO:0000256|ARBA:ARBA00067361};
DE   AltName: Full=IFN-alpha-responsive transcription factor subunit {ECO:0000256|ARBA:ARBA00082071};
DE   AltName: Full=ISGF3 p48 subunit {ECO:0000256|ARBA:ARBA00081569};
DE   AltName: Full=Interferon-stimulated gene factor 3 gamma {ECO:0000256|ARBA:ARBA00077133};
DE   AltName: Full=Transcriptional regulator ISGF3 subunit gamma {ECO:0000256|ARBA:ARBA00076458};
GN   Name=IRF9 {ECO:0000313|Ensembl:ENSEASP00005036572.1};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005036572.1, ECO:0000313|Proteomes:UP000694387};
RN   [1] {ECO:0000313|Ensembl:ENSEASP00005036572.1, ECO:0000313|Proteomes:UP000694387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33293529;
RA   Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA   Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA   C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA   J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA   Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA   Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA   S., Zhou, X. and Zhong, J.;
RT   "Donkey genomes provide new insights into domestication and selection for
RT   coat color.";
RL   Nat. Commun. 11:6014-6014(2020).
RN   [2] {ECO:0000313|Ensembl:ENSEASP00005036572.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- FUNCTION: Transcription factor that plays an essential role in anti-
CC       viral immunity. It mediates signaling by type I IFNs (IFN-alpha and
CC       IFN-beta). Following type I IFN binding to cell surface receptors, Jak
CC       kinases (TYK2 and JAK1) are activated, leading to tyrosine
CC       phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the
CC       phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3
CC       transcription factor, that enters the nucleus. ISGF3 binds to the IFN
CC       stimulated response element (ISRE) to activate the transcription of
CC       interferon stimulated genes, which drive the cell in an antiviral
CC       state. {ECO:0000256|ARBA:ARBA00055896}.
CC   -!- SUBUNIT: Interacts with STAT2 in the cytoplasm. Forms the interferon-
CC       stimulated gene factor 3 complex (ISGF3) with the heterodimer
CC       STAT1:STAT2; upon stimulation. {ECO:0000256|ARBA:ARBA00062547}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00840}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00840}.
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DR   RefSeq; XP_014724060.1; XM_014868574.3.
DR   AlphaFoldDB; A0A9L0I7X9; -.
DR   Ensembl; ENSEAST00005045492.1; ENSEASP00005036572.1; ENSEASG00005011944.2.
DR   GeneID; 106848581; -.
DR   CTD; 10379; -.
DR   GeneTree; ENSGT00940000162115; -.
DR   Proteomes; UP000694387; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0002376; P:immune system process; IEA:TreeGrafter.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProtKB-ARBA.
DR   CDD; cd00103; IRF; 1.
DR   FunFam; 1.10.10.10:FF:000041; Interferon regulatory factor 4; 1.
DR   FunFam; 2.60.200.10:FF:000009; interferon regulatory factor 9 isoform X1; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR019471; Interferon_reg_factor-3.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR   PANTHER; PTHR11949:SF26; INTERFERON REGULATORY FACTOR 9; 1.
DR   Pfam; PF00605; IRF; 1.
DR   Pfam; PF10401; IRF-3; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SMART; SM01243; IRF-3; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00840};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00840}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE-
KW   ProRule:PRU00840};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PROSITE-ProRule:PRU00840}.
FT   DOMAIN          9..116
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000259|PROSITE:PS51507"
FT   REGION          114..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..187
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  46689 MW;  21ABAF9A01747812 CRC64;
     MASGRARCTR KLRNWVVEQV ESGQFPGVCW DDAAKTMFRI PWKHAGKQDF REDQDAAFFK
     AWAIFKGKYK EGDTEGPAIW KTRLRCALNK SLEFEEVPEN GHRDGAEPYK VYRLLPPGTL
     PAQPGTQKSP SKRHHSSVSS EREEDGGTRK NCILSPSLPQ DPLKNEEVVA NGDSGHSDFG
     SSSSSNSPEP QEEPCADQVD PWGEALVQMA TDYSLLLTFI YDGRVVGEAQ VQSLDCRLVA
     EPSGSQYGME QVVFPKPGPQ EPTQRLLSQL ERGVLVASNS RGLFVQRLCP IPISWNAPRT
     PPGPGPHLLP SNKCVELFRT THFCRDLARY FQGLGPPPKF RVTLNFWEES PDRSHTPKSL
     ITVQMEQAFA RHLLEETPEE QAAILSLVQS LGSPPSSSPL CSPVSFERDS FSTLATGLPQ
     C
//