# ORC5 donkey gene models vs human/mouse/horse ORC5 (re-review)

Generated by `uv run --script compare_gene_models_rereview.py` (UniProt REST, live).
Global alignment to human O43913, BLOSUM62, gap open -10, extend -0.5, free end gaps.

| accession | source | length | identity to human (%) | human coverage (%) | C-terminal 20 aa | human-type C-terminus (YLYDFL) | proteome | Ensembl gene |
|---|---|---|---|---|---|---|---|---|
| O43913 | human | 435 | 100.0 | 100.0 | IRAIARTVNFDIIKYLYDFL | True | UP000005640 | ENSG00000164815.12 |
| Q9WUV0 | mouse | 435 | 93.79 | 100.0 | IRAIARMVNFDIIKYLYDFL | True | UP000000589 | ENSMUSG00000029012.12 |
| A0A3Q2KSP7 | horse | 437 | 90.51 | 99.31 | IRAIARTVNFDIIKYLYDFL | True | UP000002281 | ENSECAG00000007885.4 |
| A0A8C4MMX6 | donkey | 422 | 95.26 | 97.01 | DGPKYKCTVSLDFIRAIASG | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0I6Y4 | donkey | 435 | 95.86 | 100.0 | IRAIARTVNFDIIKYLYDFL | True | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0I825 | donkey | 453 | 89.55 | 96.78 | HYTMGLAPLYFLMKLNSCQP | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0IGM8 | donkey | 435 | 95.07 | 97.93 | IRAIARLNDPIFQVACSPWN | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0II85 | donkey | 440 | 94.87 | 98.62 | SFQSFQDIILPALWLWQRWQ | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0J0X9 | donkey | 430 | 89.13 | 95.17 | HCPSPVLGAGARFELVLEWS | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0JAR4 | donkey | 440 | 94.84 | 97.93 | RGPPKTCLQTHKNRLTMSSH | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0K651 | donkey | 450 | 93.95 | 98.85 | NENFQEWDPSTHTFNTTVLP | False | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0KD90 | donkey | 463 | 95.86 | 100.0 | IRAIARTVNFDIIKYLYDFL | True | UP000694387 | ENSEASG00005017348.2 |
| A0A9L0KFQ4 | donkey | 474 | 95.86 | 100.0 | IRAIARTVNFDIIKYLYDFL | True | UP000694387 | ENSEASG00005017348.2 |

Benchmark accession A0A9L0JAR4: length 440, identity 94.84% to human over 426 paired residues; C-terminus RGPPKTCLQTHKNRLTMSSH; human-type C-terminus present: False.

Human ORC5 Walker A (residues 37-44) GHTASGKT vs A0A9L0JAR4 GHTASGKT; human DNA-proximal beta-hairpin H398 vs A0A9L0JAR4 residue 398 H.
Residues 1-420: 402/420 identical to human; human 421-435 RTVNFDIIKYLYDFL vs A0A9L0JAR4 421-440 RGPPKTCLQTHKNRLTMSSH.