ID   A0A9L0JAR4_EQUAS        Unreviewed;       440 AA.
AC   A0A9L0JAR4;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   02-SEP-2026, entry version 15.
DE   RecName: Full=Origin recognition complex subunit 5 {ECO:0000256|ARBA:ARBA00069657};
GN   Name=ORC5 {ECO:0000313|Ensembl:ENSEASP00005050401.1};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005050401.1, ECO:0000313|Proteomes:UP000694387};
RN   [1] {ECO:0000313|Ensembl:ENSEASP00005050401.1, ECO:0000313|Proteomes:UP000694387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33293529;
RA   Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA   Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA   C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA   J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA   Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA   Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA   S., Zhou, X. and Zhong, J.;
RT   "Donkey genomes provide new insights into domestication and selection for
RT   coat color.";
RL   Nat. Commun. 11:6014-6014(2020).
RN   [2] {ECO:0000313|Ensembl:ENSEASP00005050401.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication. {ECO:0000256|ARBA:ARBA00057448}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase.
CC       {ECO:0000256|ARBA:ARBA00026084}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ORC5 family.
CC       {ECO:0000256|ARBA:ARBA00006269}.
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DR   AlphaFoldDB; A0A9L0JAR4; -.
DR   Ensembl; ENSEAST00005079352.1; ENSEASP00005050401.1; ENSEASG00005017348.2.
DR   GeneTree; ENSGT00390000009380; -.
DR   Proteomes; UP000694387; Chromosome 1.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:TreeGrafter.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:TreeGrafter.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:TreeGrafter.
DR   FunFam; 3.40.50.300:FF:000673; Origin recognition complex subunit 5; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR020796; ORC5.
DR   InterPro; IPR047088; ORC5_C.
DR   InterPro; IPR048866; ORC5_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12705; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR   PANTHER; PTHR12705:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14630; ORC5_C; 1.
DR   Pfam; PF21639; ORC5_lid; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694387}.
FT   DOMAIN          8..155
FT                   /note="Orc1-like AAA ATPase"
FT                   /evidence="ECO:0000259|Pfam:PF13191"
FT   DOMAIN          204..271
FT                   /note="ORC5 lid"
FT                   /evidence="ECO:0000259|Pfam:PF21639"
FT   DOMAIN          302..421
FT                   /note="Origin recognition complex subunit 5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14630"
SQ   SEQUENCE   440 AA;  50569 MW;  BA6506602BA4A531 CRC64;
     MAHLENLVLC RESQVSTLQS VFGERQHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF
     VNCVECFTLR LLLEQILNKL NHLSSSEDAC PTHITCETFN DFVCLFKQVT KAESLKDQTV
     YIVLDKAEYL RDMEANLLPG FLRLQELTDR NVTVILLSEI VWEKFRPNTG CFEPFVLYFP
     DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV
     VKGEASERDT RKLWRNVEPH LKKAMQTVYL REISSSQWEK IQKDDTDPGQ LKGLSAYTHV
     ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD
     RLLAILYSIV DSRVAATANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA
     RGPPKTCLQT HKNRLTMSSH
//