ID A0A9L0JMP6_EQUAS Unreviewed; 765 AA. AC A0A9L0JMP6; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 10-JUN-2026, entry version 13. DE RecName: Full=Protein transport protein SEC23 {ECO:0000256|RuleBase:RU365030}; GN Name=SEC23A {ECO:0000313|Ensembl:ENSEASP00005050435.1}; OS Equus asinus (Donkey) (Equus africanus asinus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005050435.1, ECO:0000313|Proteomes:UP000694387}; RN [1] {ECO:0000313|Ensembl:ENSEASP00005050435.1, ECO:0000313|Proteomes:UP000694387} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=33293529; RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X., RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang, RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li, RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G., RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G., RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li, RA S., Zhou, X. and Zhong, J.; RT "Donkey genomes provide new insights into domestication and selection for RT coat color."; RL Nat. Commun. 11:6014-6014(2020). RN [2] {ECO:0000313|Ensembl:ENSEASP00005050435.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- FUNCTION: Component of the coat protein complex II (COPII) which CC promotes the formation of transport vesicles from the endoplasmic CC reticulum (ER). The coat has two main functions, the physical CC deformation of the endoplasmic reticulum membrane into vesicles and the CC selection of cargo molecules. {ECO:0000256|RuleBase:RU365030}. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle CC membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein CC {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side CC {ECO:0000256|RuleBase:RU365030}. Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004397, ECO:0000256|RuleBase:RU365030}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004397, CC ECO:0000256|RuleBase:RU365030}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004397, ECO:0000256|RuleBase:RU365030}. CC Cytoplasm, cytosol {ECO:0000256|RuleBase:RU365030}. CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC23 subfamily. CC {ECO:0000256|ARBA:ARBA00009210, ECO:0000256|RuleBase:RU365030}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_014699598.1; XM_014844112.3. DR RefSeq; XP_014699600.1; XM_014844114.3. DR RefSeq; XP_044621470.1; XM_044765535.2. DR RefSeq; XP_044621471.1; XM_044765536.2. DR AlphaFoldDB; A0A9L0JMP6; -. DR Ensembl; ENSEAST00005083518.1; ENSEASP00005050435.1; ENSEASG00005007615.2. DR GeneID; 106833069; -. DR KEGG; eai:106833069; -. DR CTD; 10484; -. DR GeneTree; ENSGT00390000006916; -. DR OMA; FPPHYAE; -. DR Proteomes; UP000694387; Chromosome 2. DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:TreeGrafter. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005096; F:GTPase activator activity; IEA:TreeGrafter. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:TreeGrafter. DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro. DR CDD; cd01478; Sec23-like; 1. DR CDD; cd11287; Sec23_C; 1. DR FunFam; 1.20.120.730:FF:000003; Protein transport protein SEC23; 1. DR FunFam; 2.30.30.380:FF:000001; Protein transport protein SEC23; 1. DR FunFam; 2.60.40.1670:FF:000006; Protein transport protein SEC23; 1. DR FunFam; 3.40.20.10:FF:000003; Protein transport protein SEC23; 1. DR FunFam; 3.40.50.410:FF:000011; Protein transport protein SEC23; 1. DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1. DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1. DR Gene3D; 3.40.20.10; Severin; 1. DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1. DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1. DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf. DR InterPro; IPR012990; Beta-sandwich_Sec23_24. DR InterPro; IPR007123; Gelsolin-like_dom. DR InterPro; IPR036180; Gelsolin-like_dom_sf. DR InterPro; IPR037364; Sec23. DR InterPro; IPR006900; Sec23/24_helical_dom. DR InterPro; IPR036175; Sec23/24_helical_dom_sf. DR InterPro; IPR006896; Sec23/24_trunk_dom. DR InterPro; IPR037550; Sec23_C. DR InterPro; IPR036465; vWFA_dom_sf. DR InterPro; IPR006895; Znf_Sec23_Sec24. DR InterPro; IPR036174; Znf_Sec23_Sec24_sf. DR PANTHER; PTHR11141; PROTEIN TRANSPORT PROTEIN SEC23; 1. DR PANTHER; PTHR11141:SF7; PROTEIN TRANSPORT PROTEIN SEC23A; 1. DR Pfam; PF00626; Gelsolin; 1. DR Pfam; PF08033; Sec23_BS; 1. DR Pfam; PF04815; Sec23_helical; 1. DR Pfam; PF04811; Sec23_trunk; 1. DR Pfam; PF04810; zf-Sec23_Sec24; 1. DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1. DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1. DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1. DR SUPFAM; SSF53300; vWA-like; 1. DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365030}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329, KW ECO:0000256|RuleBase:RU365030}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU365030}; KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892, KW ECO:0000256|RuleBase:RU365030}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365030}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU365030}; KW Protein transport {ECO:0000256|ARBA:ARBA00022927, KW ECO:0000256|RuleBase:RU365030}; KW Reference proteome {ECO:0000313|Proteomes:UP000694387}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365030}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU365030}. FT DOMAIN 58..98 FT /note="Zinc finger Sec23/Sec24-type" FT /evidence="ECO:0000259|Pfam:PF04810" FT DOMAIN 126..390 FT /note="Sec23/Sec24 trunk" FT /evidence="ECO:0000259|Pfam:PF04811" FT DOMAIN 401..504 FT /note="Sec23/Sec24 beta-sandwich" FT /evidence="ECO:0000259|Pfam:PF08033" FT DOMAIN 518..616 FT /note="Sec23/Sec24 helical" FT /evidence="ECO:0000259|Pfam:PF04815" FT DOMAIN 632..718 FT /note="Gelsolin-like" FT /evidence="ECO:0000259|Pfam:PF00626" SQ SEQUENCE 765 AA; 86203 MW; 7E254DA0D56220DA CRC64; MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD LPPIQYEPVL CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG ISEMNQPAEL LPQFSSIEYV VLRGPQMPLI FLYVVDTCME DEDLQALKES MQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLSAKQL QEMLGLSKVP VTQATRGPQV QQPPPSNRFL QPVQKIDMNL TDLLGELQRD PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM VVGDELKTPI RSWHDIEKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC ALDQTGLLEM KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDMHGQFKM GFGGTLEIKT SREIKISGAI GPCVSLNSKG PCVSENEIGT GGTCQWKICG LSPTTTLAIY FEVVNQHNAP IPQGGRGAIQ FVTQYQHSSG QRRIRVTTIA RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP DVLRWLDRQL IRLCQKFGEY HKDDPSSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM DTFFQILIYH GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ VFMDHLKKLA VSSAA //