id: A0A9L0JV53
gene_symbol: SLC16A11
taxon:
  id: NCBITaxon:9793
  label: Equus asinus
status: COMPLETE
description: Assessment of the single ProtNLM2 GO prediction for donkey SLC16A11 (A0A9L0JV53), judged against
  the donkey GOA record (ER membrane, plasma membrane, monocarboxylic acid transmembrane transporter activity,
  monocarboxylic acid transport, transmembrane transporter activity, transmembrane transport), experimental
  evidence that human MCT11 (Q8NCK7) is a proton-coupled pyruvate transporter, and donkey-human alignments showing
  that this gene model lacks the region of transmembrane helices 1-3 while its remaining residues are identical
  to the full-length donkey model A0A8C4PS96. The prediction, transmembrane transporter activity, is true of the gene but is scored as
  incorrect for this product (NPI, domain architecture mismatch), because the polypeptide lacks transmembrane helices
  1-3 of the transport fold. The frozen ProtNLM2 output
  contains no non-GO rows (function text or subcellular location) for this accession.
source_documents:
- projects/PROTNLM_EVALUATION/donkey40/donkey40-predictions.tsv
- genes/EQUAS/SLC16A11/SLC16A11-goa.tsv
- genes/EQUAS/SLC16A11/SLC16A11-bioinformatics/SLC16A11-human-Q8NCK7-uniprot.txt
- genes/EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS.md
- genes/EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS-rereview.md
- genes/EQUAS/SLC16A11/SLC16A11-ai-review.yaml
- publications/PMID_28666119.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-10-14
  predicted_term:
    id: GO:0022857
    label: transmembrane transporter activity
  predicted_term_type: GO_MF
  review:
    assessment: NPI
    error_type: DOMAIN_ARCHITECTURE_MISMATCH
    confidence_score: 0
    summary: Scored for the A0A9L0JV53 polypeptide, an alternative transcript model of donkey SLC16A11 (MCT11,
      PANTHER PTHR11360:SF80). Transmembrane transporter activity is true of the gene, since human MCT11 transports
      pyruvate with a proton and the full-length donkey model A0A8C4PS96 has the complete fold, but this product
      lacks the region of transmembrane helices 1-3 of the twelve-helix major facilitator fold. Its first 107 residues
      are an unrelated sequence with no counterpart of human TM1-TM3, and only residues 108-439 (human 116-447)
      are shared with the full-length model. A major facilitator transporter missing three helices of its N-terminal
      six-helix bundle lacks part of the translocation pathway, so this exact polypeptide is not expected to transport
      on its own. The prediction depends on a feature this accession lacks.
    supported_by:
    - reference_id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/SLC16A11-human-Q8NCK7-uniprot.txt
      supporting_text: Proton-linked monocarboxylate transporter. It catalyzes the
    - reference_id: PMID:28666119
      supporting_text: These results support a H+-coupled mechanism underlying SLC16A11 transport
    - reference_id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS.md
      supporting_text: The human N-terminal region containing predicted transmembrane helices 1-3 (human 12-32,
        54-74, 82-102) therefore has no homologous counterpart in the donkey model
    - reference_id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS-rereview.md
      supporting_text: Its residues 108-439 are identical to A0A8C4PS96 residues 189-520, which correspond to human
        residues 116-447.
    - reference_id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS-rereview.md
      supporting_text: if it is, the product would be a truncated MFS fold and is unlikely to transport on its own
references:
- id: PMID:28666119
  title: Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
  findings: []
- id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/SLC16A11-human-Q8NCK7-uniprot.txt
  title: UniProt Swiss-Prot record for human SLC16A11 (Q8NCK7)
  findings: []
- id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS.md
  title: 'SLC16A11: donkey-human sequence comparison'
  findings: []
- id: file:EQUAS/SLC16A11/SLC16A11-bioinformatics/RESULTS-rereview.md
  title: 'SLC16A11 (donkey): comparison of all donkey gene models with human MCT11'
  findings: []