# TGFBR3: donkey-human comparison

Donkey A0A8C4M6Z6 (836 aa) aligned globally to human Q03167 (851 aa): 89.47% identity over 836 paired residues; paired coverage 98.24% of human and 100.0% of donkey.

Donkey ranges (>=5 aa) without a human partner: none.
Human ranges (>=5 aa) without a donkey partner: [[763, 776]].

Method: Biopython PairwiseAligner, global, BLOSUM62, gap open -10, extend -0.5. Regenerate with `uv run python genes/EQUAS/TGFBR3/TGFBR3-bioinformatics/compare.py`. Pairwise similarity does not by itself establish orthology or function.

## Human UniProt features mapped onto the donkey sequence

- SIGNAL : human [1, 20] MA -> donkey [1, 20] MA; 17 of 20 human residues in this span are identical in the aligned donkey sequence (20 paired; aligned donkey span length 20)
- TRANSMEM Helical: human [788, 809] MY -> donkey [773, 794] MY; 22 of 22 human residues in this span are identical in the aligned donkey sequence (22 paired; aligned donkey span length 22)
- DOMAIN ZP: human [455, 730] KC -> donkey [454, 729] KC; 240 of 276 human residues in this span are identical in the aligned donkey sequence (276 paired; aligned donkey span length 276)
- DISULFID : human [52, 197] CC -> donkey [52, 197] CC; 134 of 146 human residues in this span are identical in the aligned donkey sequence (146 paired; aligned donkey span length 146)
- DISULFID : human [639, 705] CC -> donkey [638, 704] CC; 59 of 67 human residues in this span are identical in the aligned donkey sequence (67 paired; aligned donkey span length 67)
- DISULFID : human [660, 730] CC -> donkey [659, 729] CC; 65 of 71 human residues in this span are identical in the aligned donkey sequence (71 paired; aligned donkey span length 71)
- DISULFID : human [710, 723] CC -> donkey [709, 722] CC; 12 of 14 human residues in this span are identical in the aligned donkey sequence (14 paired; aligned donkey span length 14)

## Human non-IEA GO annotations (human-Q03167-quickgo-annotations.tsv, QuickGO download)

- NOT|involved_in GO:0046328 [ISS GO_REF:0000024]
- NOT|involved_in GO:0070372 [ISS GO_REF:0000024]
- contributes_to GO:0005515 [IPI PMID:10746731]
- contributes_to GO:0050431 [IBA GO_REF:0000033]
- contributes_to GO:0050431 [IPI PMID:11157754]
- enables GO:0004888 [IDA PMID:18184661]
- enables GO:0005024 [IBA GO_REF:0000033]
- enables GO:0005024 [IDA PMID:12958365]
- enables GO:0005114 [IBA GO_REF:0000033]
- enables GO:0005114 [IDA PMID:11157754]
- enables GO:0005160 [ISS PMID:1333192]
- enables GO:0005515 [IPI PMID:10746731]
- enables GO:0005515 [IPI PMID:11157754]
- enables GO:0005515 [IPI PMID:11546783]
- enables GO:0005515 [IPI PMID:12958365]
- enables GO:0005515 [IPI PMID:20856203]
- enables GO:0005515 [IPI PMID:35922511]
- enables GO:0005539 [ISS GO_REF:0000024]
- enables GO:0005539 [IBA GO_REF:0000033]
- enables GO:0005539 [TAS PMID:1333192]
- enables GO:0008201 [ISS PMID:1333192]
- enables GO:0015026 [IDA PMID:10746731]
- enables GO:0030165 [ISS GO_REF:0000024]
- enables GO:0036122 [IPI PMID:18184661]
- enables GO:0046332 [IMP PMID:11157754]
- enables GO:0050431 [IDA PMID:11157754]
- enables GO:0050431 [IDA PMID:12958365]
- enables GO:0070123 [IDA PMID:10746731]
- enables GO:0070123 [IDA PMID:11157754]
- involved_in GO:0001837 [IBA GO_REF:0000033]
- involved_in GO:0001837 [IDA PMID:18184661]
- involved_in GO:0001889 [ISS GO_REF:0000024]
- involved_in GO:0003007 [ISS GO_REF:0000024]
- involved_in GO:0003150 [ISS GO_REF:0000024]
- involved_in GO:0003151 [ISS GO_REF:0000024]
- involved_in GO:0003223 [ISS GO_REF:0000024]
- involved_in GO:0006955 [IMP PMID:16886151]
- involved_in GO:0007179 [ISS GO_REF:0000024]
- involved_in GO:0007179 [IBA GO_REF:0000033]
- involved_in GO:0007179 [IMP PMID:11157754]
- involved_in GO:0007179 [IDA PMID:12958365]
- involved_in GO:0007179 [IDA PMID:29130787]
- involved_in GO:0007179 [IMP PMID:30467960]
- involved_in GO:0010628 [IMP PMID:30467960]
- involved_in GO:0016477 [ISS GO_REF:0000024]
- involved_in GO:0016477 [IBA GO_REF:0000033]
- involved_in GO:0017015 [IBA GO_REF:0000033]
- involved_in GO:0030336 [IDA PMID:29130787]
- involved_in GO:0030509 [IDA PMID:18184661]
- involved_in GO:0032354 [IDA PMID:14557487]
- involved_in GO:0034695 [IDA PMID:14557487]
- involved_in GO:0034699 [IDA PMID:14557487]
- involved_in GO:0035556 [IMP PMID:14557487]
- involved_in GO:0043124 [IDA PMID:29130787]
- involved_in GO:0050680 [ISS GO_REF:0000024]
- involved_in GO:0055010 [ISS GO_REF:0000024]
- involved_in GO:0060038 [ISS GO_REF:0000024]
- involved_in GO:0060045 [ISS GO_REF:0000024]
- involved_in GO:0060216 [ISS GO_REF:0000024]
- involved_in GO:0060317 [IDA PMID:18184661]
- involved_in GO:0060318 [ISS GO_REF:0000024]
- involved_in GO:0060347 [ISS GO_REF:0000024]
- involved_in GO:0060391 [IMP PMID:11157754]
- involved_in GO:0060391 [IDA PMID:18184661]
- involved_in GO:0060391 [IMP PMID:30729664]
- involved_in GO:0060392 [IMP PMID:30729664]
- involved_in GO:0060412 [ISS GO_REF:0000024]
- involved_in GO:0060939 [ISS GO_REF:0000024]
- involved_in GO:0060979 [ISS GO_REF:0000024]
- involved_in GO:0061384 [ISS GO_REF:0000024]
- involved_in GO:0062009 [ISS GO_REF:0000024]
- involved_in GO:0090050 [IMP PMID:30467960]
- involved_in GO:1901202 [IMP PMID:30729664]
- is_active_in GO:0005886 [IBA GO_REF:0000033]
- located_in GO:0005576 [ISS GO_REF:0000024]
- located_in GO:0005576 [HDA PMID:16502470]
- located_in GO:0005576 [TAS PMID:18184661]
- located_in GO:0005576 [TAS Reactome:R-HSA-9839367]
- located_in GO:0005576 [TAS Reactome:R-HSA-9839368]
- located_in GO:0005829 [TAS Reactome:R-HSA-9839388]
- located_in GO:0005829 [TAS Reactome:R-HSA-9839396]
- located_in GO:0005886 [ISS GO_REF:0000024]
- located_in GO:0005886 [EXP PMID:19416857]
- located_in GO:0005886 [EXP PMID:19726563]
- located_in GO:0005886 [EXP PMID:22562249]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839358]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839363]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839367]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839377]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839378]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839379]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839381]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839384]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839388]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839390]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839401]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839402]
- located_in GO:0005886 [TAS Reactome:R-HSA-9839405]
- located_in GO:0009897 [IDA PMID:12958365]
- located_in GO:0009986 [ISS GO_REF:0000024]
- located_in GO:0016323 [TAS Reactome:R-HSA-9839367]
- located_in GO:0016323 [TAS Reactome:R-HSA-9839376]
- located_in GO:0070062 [HDA PMID:19056867]
- located_in GO:0070062 [HDA PMID:19199708]
- part_of GO:0034673 [IDA PMID:10746731]
- part_of GO:0043235 [IDA PMID:11157754]